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US4702228A Expired / Lapsed US ⏱️ 0.0 years remaining

X-ray-emitting interstitial implants

Assignee: Theragenics Corp
•
Filing: 1985-01-24
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Granted: 1987-10-27
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Expires: 2005-01-24
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Abstract

Abstract Particles or "seeds" are manufactured for implantation into tumors within a human body for emitting X-rays to destroy or reduce the tumors. The seeds contain palladium which is substantially enriched in palladium-102 and which is activated by exposure to neutron flux so as to contain a minor, but significant, fraction of X-ray-emitting palladium-103. The palladium is distributed on or throughout a base material so as to reduce self-shielding by the palladium. The seeds include an X-ray-opaque marker to facilitate external visualization of the seeds after their implantation, the marker preferably being formed of a material, such as lead or rhodium, which does not activate to contain undesirable isotopes under the radiation conditions in which palladium-102 is activated to palladium-103. The base material-distributed palladium and the marker are encased in an elongated shell which is formed by welding a pair of end caps to a tubular member, the construction of the shell reducing the mass of material at the end of the seed, thereby providing a more isotropic angular distribution of X-rays.

Inventors

  • 👤 John L. Russell, Jr.
  • 👤 David N. Coggins

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 11:05
CPC Classifications
G; G21; G21G; G21G4/00; G21G4/04; G21G4/06; G21G4/08; A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1027; A61P; A61P35/00; A61N2005/1019; A61N2005/1023; A61N2005/1024; Y; Y10; Y10S; Y10S977/00; Y10S977/902; Y10S977/904; Y10S977/927; Y10S977/928

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 104 words
A seed for implantation into a tumor within a living body to emit X-ray radiation thereto comprising at least one pellet that contains palladium enriched in palladium-102 to contain many times the amount naturally present, said palladium-102 being activatable by exposure to neutron flux so as to transform a portion of said palladium-102 to an amount of X-ray emitting palladium-103 sufficient to provide a radiation level measured as compensated mCi of greater than 0.5, and a shell of biocompatible material encapsulating said at least one pellet, said biocompatible material being selected from a material that is penetratable by X-rays in the 20-23 kev range.
Claim 2
Dependent Claim 104 words
A seed for implantation into a tumor within a living body to emit X-ray radiation thereto comprising at least one pellet that contains palladium enriched in palladium-102 to contain many times the amount naturally present, said palladium-102 being activatable by exposure to neutron flux so as to transform a portion of said palladium-102 to an amount of X-ray emitting palladium-103 sufficient to provide a radiation level measured as compensated mCi of greater than 0.5, and a shell of biocompatible material encapsulating said at least one pellet, said biocompatible material being selected from a material that is penetratable by X-rays in the 20-23 kev range.
Claim 3
Dependent Claim 58 words
An implantable seed according to claim 1 wherein said seed includes a base material and wherein said Pd-102-enriched palladium is distributed on or throughout said base material, the distribution of said Pd-102-enriched palladium on or throughout said base material ensuring that at least about 30% of the X-rays generated by the palladium-103 will be emitted from said particle.
Claim 4
Dependent Claim 15 words
An implantable seed according to claim 2 wherein said base material comprises compacted aluminum powder.
Claim 5
Dependent Claim 30 words
An implantable seed according to claim 1 wherein said seed also includes an X-ray-opaque marker within said shell for external visualization of said particle after its implantation in the body.
Claim 6
Dependent Claim 25 words
An implantable seed according to claim 4 wherein the material forming said X-ray-opaque marker is selected from the group consisting of lead, rhodium and palladium.
Claim 7
Dependent Claim 53 words
An implantable seed according to claim 4 wherein said shell has a generally tubular configuration, said marker is generally centrally located, and said at least one pellet includes two pellets, with one pellet disposed on either side of said marker to help promote a generally isotropic distribution of X-rays emitted from said particle.
Claim 8
Dependent Claim 25 words
An implantable seed according to claim 4 wherein said marker is formed of a material selected from the group consisting of lead, rhodium and palladium.
Claim 9
Dependent Claim 22 words
An implantable seed according to claim 1 wherein said shield is formed of titanium that contains no more than 0.05 percent iron.
Claim 10
Dependent Claim 20 words
An implantable seed according to claim 1 wherein said palladium is enriched to include at least about 50% in palladium-102.

References Cited (Backward Citations)

US3351049A Cited
US4323055A Cited
US4510924A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1990-10-26 1991-04-27 1991-10-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1994-10-26 1995-04-27 1995-10-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1998-10-26 1999-04-27 1999-10-27 $7700.00 Window Closed / Lapsed

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