US5358702A
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Methoxylated gel particle contrast media for improved diagnostic imaging
Assignee: ImaRx Therapeutics Inc
•
Filing: 1993-05-14
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Granted: 1994-10-25
•
Expires: 2013-05-14
Abstract
Abstract A contrast medium useful for diagnostic imaging is provided. The contrast medium comprises gel particles, preferably of less than about 90 mu in mean diameter, the gel particles comprising at least one polymer entrapping at least one contrast enhancing metal.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:26
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0409; A61K49/0414; A61K49/06; A61K49/18; A61K49/1803; A61K49/1806; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1833; A61K49/1845; A61K49/1851; A61K49/1857; A61K49/1863; A61K49/22; A61K49/222; A61K49/226; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 65
Claim 1
Independent Claim
39 words
A pharmaceutically acceptable contrast medium comprising firm gel particles of less than about 90μ in mean diameter, said firm gel particles comprising at least one methoxylated natural or methoxylated modified natural polymer entrapping at least one contrast enhancing metal.
Claim 2
Dependent Claim
39 words
A pharmaceutically acceptable contrast medium comprising firm gel particles of less than about 90μ in mean diameter, said firm gel particles comprising at least one methoxylated natural or methoxylated modified natural polymer entrapping at least one contrast enhancing metal.
Claim 3
Dependent Claim
21 words
A contrast medium of claim 1 wherein said gel particles are from about 5 nm to about 90μ in mean diameter.
Claim 4
Dependent Claim
20 words
A contrast medium of claim 2 wherein said gel particles are from about 1μ to about 90μ in mean diameter.
Claim 5
Dependent Claim
22 words
A contrast medium of claim 2 wherein said gel particles are from about 5 nm to about 400 nm in mean diameter.
Claim 6
Dependent Claim
22 words
A contrast medium of claim 4 wherein said gel particles are from about 10 nm to about 200 nm in mean diameter.
Claim 7
Dependent Claim
13 words
A contrast medium of claim 1 wherein the methoxylated polymer is a polysaccharide.
Claim 8
Dependent Claim
108 words
A contrast medium of claim 6 wherein said polysaccharide is selected from the group consisting of arabinans, fructans, fucans, galactans, galacturonans, glucans, mannans, xylans, levan, fucoidan, carrageenan, galactocarolose, pectins, pectic acids, amylose, pullulan, glycogen, amylopectin, cellulose, dextran, pustulan, chitin, agarose, keratin, chondroitin, dermatan, hyaluronic acid, alginic acid, xanthan gum, starch, carboxylmethylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, methoxycellulose, and polysaccharides containing at least one aldose, ketose, acid or amine selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose, tagarose, glucuronic acid, gluconic acid, glucaric acid, galacturonic acid, mannuronic acid, glucosamine, galactosamine and neuraminic acid.
Claim 9
Dependent Claim
11 words
A contrast medium of claim 7 wherein said polysaccharide is pectin.
Claim 10
Dependent Claim
24 words
A contrast medium of claim 8 wherein said polysaccharide is a pectin which is a low methoxy pectin having less than about 30% methoxylation.
Claim 11
Dependent Claim
12 words
A contrast medium of claim 7 wherein said polysaccharide is polygalacturonic acid.
Claim 12
Dependent Claim
14 words
A contrast medium of claim 1 wherein said methoxylated polymer is a phosphorylated polymer.
Claim 13
Dependent Claim
23 words
A contrast medium of claim 1 wherein said contrast enhancing metal is selected from the group consisting of paramagnetic metals and heavy metals.
Claim 14
Dependent Claim
15 words
A contrast medium of claim 12 wherein said contrast enhancing metal is a paramagnetic metal.
Claim 15
Dependent Claim
35 words
A contrast medium of claim 13 wherein said paramagnetic metal is selected from the group consisting of gadolinium, manganese, copper, chromium, iron, cobalt, erbium, nickel, europium, technetium, indium, samarium, dysprosium, ruthenium, ytterbium, yttrium, and holmium.
Claim 16
Dependent Claim
14 words
A contrast medium of claim 14 wherein said paramagnetic metal is Mn +2 .
Claim 17
Dependent Claim
15 words
A contrast medium of claim 12 wherein said contrast enhancing metal is a heavy metal.
Claim 18
Dependent Claim
23 words
A contrast medium of claim 16 wherein said heavy metal is selected from the group consisting of hafnium, lanthanum, ytterbium, dysprosium and gadolinium.
Claim 19
Dependent Claim
27 words
A contrast medium of claim 1 wherein said contrast medium further comprises a gelling agent selected from the group consisting of polyvalent metal cations, sugars and polyalcohols.
Claim 20
Dependent Claim
20 words
A contrast medium of claim 18 wherein said gelling agent is a polyvalent metal cation which is a calcium cation.
Claim 21
Dependent Claim
12 words
A contrast medium of claim 1 wherein said methoxylated polymer is crosslinked.
Claim 22
Dependent Claim
12 words
A contrast medium of claim 1 wherein said methoxylated polymer is non-crosslinked.
Claim 23
Dependent Claim
57 words
A pharmaceutically acceptable contrast medium prepared by the process of combining at least one methoxylated natural or methoxylated modified natural polymer and at least one contrast enhancing metal to form a firm gel wherein said polymer entraps said contrast enhancing metal, and particularizing the firm gel to form particles of less than about 90μ in mean diameter.
Claim 24
Dependent Claim
57 words
A pharmaceutically acceptable contrast medium prepared by the process of combining at least one methoxylated natural or methoxylated modified natural polymer and at least one contrast enhancing metal to form a firm gel wherein said polymer entraps said contrast enhancing metal, and particularizing the firm gel to form particles of less than about 90μ in mean diameter.
Claim 25
Dependent Claim
21 words
A contrast medium of claim 22 further comprising combining a gelling agent with said methoxylated polymer and said contrast enhancing metal.
Claim 26
Dependent Claim
23 words
A contrast medium of claim 23 wherein said gelling agent is selected from the group consisting of polyvalent metal cations, sugars and polyalcohols.
Claim 27
Dependent Claim
36 words
A pharmaceutically acceptable contrast medium comprising firm gel particles, said firm gel particles comprising at least one methoxylated natural or methoxylated modified natural polymer entrapping at least one contrast enhancing metal, wherein said polymer is non-crosslinked.
Claim 28
Dependent Claim
36 words
A pharmaceutically acceptable contrast medium comprising firm gel particles, said firm gel particles comprising at least one methoxylated natural or methoxylated modified natural polymer entrapping at least one contrast enhancing metal, wherein said polymer is non-crosslinked.
Claim 29
Dependent Claim
13 words
A contrast medium of claim 25 wherein said methoxylated polymer is a polysaccharide.
Claim 30
Dependent Claim
108 words
A contract medium of claim 26 wherein said polysaccharide is selected from the group consisting of arabinans, fructans, fucans, galactans, galacturonans, glucans, mannans, xylans, levan, fucoidan, carrageenan, galactocarolose, pectins, pectic acids, amylose, pullulan, glycogen, amylopectin, cellulose, dextran, pustulan, chitin, agarose, keratin, chondroitin, dermatan, hyaluronic acid, alginic acid, xanthan gum, starch, carboxylmethylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, methylcellulose, methoxycellulose, and polysaccharides containing at least one aldose, ketose, acid or amine selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose, tagatose, glucuronic acid, gluconic acid, glucaric acid, galacturonic acid, mannuronic acid, glucosamine, galactosamine and neuraminic acid.
Claim 31
Dependent Claim
11 words
A contrast medium of claim 27 wherein said polysaccharide is pectin.
Claim 32
Dependent Claim
24 words
A contrast medium of claim 28 wherein said polysaccharide is a pectin which is a low methoxy pectin having less than about 30% methoxylation.
Claim 33
Dependent Claim
12 words
A contrast medium of claim 27 wherein said polysaccharide is polygalacturonic acid.
Claim 34
Dependent Claim
14 words
A contrast medium of claim 25 wherein said methoxylated polymer is a phosphorylated polymer.
Claim 35
Dependent Claim
23 words
A contrast medium of claim 25 wherein said contrast enhancing metal is selected from the group consisting of paramagnetic metals and heavy metals.
Claim 36
Dependent Claim
15 words
A contrast medium of claim 32 wherein said contrast enhancing metal is a paramagnetic metal.
Claim 37
Dependent Claim
35 words
A contrast medium of claim 33 wherein said paramagnetic metal is selected from the group consisting of gadolinium, manganese, copper, chromium, iron, cobalt, erbium, nickel, europium, technetium, indium, samarium, dysprosium, ruthenium, ytterbium, yttrium, and holmium.
Claim 38
Dependent Claim
14 words
A contrast medium of claim 34 wherein said paramagnetic metal is Mn +2 .
Claim 39
Dependent Claim
15 words
A contrast medium of claim 32 wherein said contrast enhancing metal is a heavy metal.
Claim 40
Dependent Claim
23 words
A contrast medium of claim 36 wherein said heavy metal is selected from the group consisting of hafnium, lanthanum, ytterbium, dysprosium and gadolinium.
Claim 41
Dependent Claim
18 words
A contrast medium of claim 25 wherein said gel particles are less than about 90μ in mean diameter.
Claim 42
Dependent Claim
21 words
A contrast medium of claim 38 wherein said gel particles are from about 5 nm to about 90μ in mean diameter.
Claim 43
Dependent Claim
20 words
A contrast medium of claim 39 which said gel particles are from about 1μ to about 90μ in mean diameter.
Claim 44
Dependent Claim
22 words
A contrast medium of claim 39 wherein said gel particles are from about 5 nm to about 400 nm in mean diameter.
Claim 45
Dependent Claim
22 words
A contrast medium of claim 41 wherein said gel particles are from about 10 nm to about 200 nm in mean diameter.
Claim 46
Dependent Claim
53 words
A pharmaceutically acceptable contrast medium prepared by the process of combining at least one methoxylated natural or methoxylated modified natural polymer and at least one contrast enhancing metal to form a firm gel wherein said polymer entraps said contrast enhancing metal, and particularizing the gel to form particles, wherein said polymer is non-crosslinked.
Claim 47
Dependent Claim
53 words
A pharmaceutically acceptable contrast medium prepared by the process of combining at least one methoxylated natural or methoxylated modified natural polymer and at least one contrast enhancing metal to form a firm gel wherein said polymer entraps said contrast enhancing metal, and particularizing the gel to form particles, wherein said polymer is non-crosslinked.
Claim 48
Dependent Claim
21 words
A contrast medium of claim 43 further comprising combining a gelling agent with said methoxylated polymer and said contrast enhancing agent.
Claim 49
Dependent Claim
23 words
A contrast medium of claim 44 wherein said gelling agent is selected from the group consisting of polyvalent metal cations, sugars, and polyalcohols.
Claim 50
Dependent Claim
14 words
A kit comprising a contrast medium of claim 1 and conventional diagnostic kit components.
Claim 51
Dependent Claim
23 words
A kit of claim 46 wherein said kit components are selected from the group consisting of buffering agents, antibacterial agents and stabilizing agents.
Claim 52
Dependent Claim
14 words
A kit comprising a contrast agent of claim 25 and conventional diagnostic kit components.
Claim 53
Dependent Claim
23 words
A kit of claim 48 wherein said kit components are selected from the group consisting of buffering agents, antibacterial agents and stabilizing agents.
Claim 54
Dependent Claim
25 words
The contrast medium of claim 1 wherein said methoxylated polymer is polygalacturonic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 55
Dependent Claim
25 words
The contrast medium of claim 25 wherein said methoxylated polymer is polygalacturonic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 56
Dependent Claim
24 words
The kit of claim 46 wherein said methoxylated polymer is polygalacturonic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 57
Dependent Claim
24 words
The kit of claim 48 wherein said methoxylated polymer is polygalacturonic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 58
Dependent Claim
16 words
The contrast medium of claim 50 further comprising a gelling agent which is a calcium cation.
Claim 59
Dependent Claim
16 words
The contrast medium of claim 51 further comprising a gelling agent which is a calcium cation.
Claim 60
Dependent Claim
15 words
The kit of claim 52 further comprising a gelling agent which is a calcium cation.
Claim 61
Dependent Claim
15 words
The kit of claim 53 further comprising a gelling agent which is a calcium cation.
Claim 62
Dependent Claim
25 words
The contrast medium of claim 1 wherein said methoxylated polymer is hyaluronic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 63
Dependent Claim
25 words
The contrast medium of claim 25 wherein said methoxylated polymer is hyaluronic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
Claim 64
Dependent Claim
24 words
The kit of claim 46 wherein said methoxylated polymer is hyaluronic acid and said contrast enhancing metal is the paramagnetic metal Mn -2 .
Claim 65
Dependent Claim
24 words
The kit of claim 48 wherein said methoxylated polymer is hyaluronic acid and said contrast enhancing metal is the paramagnetic metal Mn +2 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-24 | 1998-04-25 | 1998-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-24 | 2002-04-25 | 2002-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-24 | 2006-04-25 | 2006-10-25 | $7700.00 | Window Closed / Lapsed |