US4985233A
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US
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A diagnostic agent containing a non-radioactive paramagnetic metal species in a macromolecular carrier
Assignee: GE Healthcare AS
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Filing: 1985-11-01
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Granted: 1991-01-15
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Expires: 2005-11-01
Abstract
Abstract A paramagnetic metal species-containing diagnostic agent is disclosed which comprises a non-radioactive paramagnetic metal species and, as a carrier therefor, a physiologically tolerable, water-insoluble, hydroxyl group-containing, particulate macromolecular product consisting essentially of at least one polymeric or polymerized carbohydrate or polymerized sugar alcohol or derivative thereof.
Inventors
- 👤 Jo Klaveness
- 👤 Trond Jacobsen
- 👤 Bernt J. Lindberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:26
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/128; A61K49/18; A61K49/1818; A61K49/1821; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
94 words
A method of diagnosis which method comprises administering to a human or a non-human animal body or to a selected region thereof a contrast effective amount of a diagnostic agent comprising a physiologically tolerable, water insoluble, water-swellable, hydroxyl group containing, particulate macromolecular product which is cross-linked to form a three-dimensional network and carries within cavities therein at least one non-radioactive paramagnetic metal species, said product comprising at least one water-insoluble material selected from the group consisting of polysaccharides, polymerized sugar alcohols and derivatives thereof; and generating an NMR or ultrasound image of said region.
Claim 2
Independent Claim
94 words
A method of diagnosis which method comprises administering to a human or a non-human animal body or to a selected region thereof a contrast effective amount of a diagnostic agent comprising a physiologically tolerable, water insoluble, water-swellable, hydroxyl group containing, particulate macromolecular product which is cross-linked to form a three-dimensional network and carries within cavities therein at least one non-radioactive paramagnetic metal species, said product comprising at least one water-insoluble material selected from the group consisting of polysaccharides, polymerized sugar alcohols and derivatives thereof; and generating an NMR or ultrasound image of said region.
Claim 3
Independent Claim
96 words
A method of diagnosis which method comprises administering to a human or non-human animal body or to a selected region thereof a constant effective amount of a diagnostic agent comprising a physiologically tolerable, water insoluble, water-swellable, hydroxyl group containing macromolecular product comprising particles of a water-insoluble macromolecular material selected from the group consisting of starch, dextrin and derivatives thereof which particles carry in cavities therein at least one non-radioactive paramagnetic metal species, said particles in aqueous media having particle sizes in the range of 6-200 micrometers, and generating an NMR or ultrasound image of said region.
Claim 4
Independent Claim
96 words
A method of diagnosis which method comprises administering to a human or non-human animal body or to a selected region thereof a constant effective amount of a diagnostic agent comprising a physiologically tolerable, water insoluble, water-swellable, hydroxyl group containing macromolecular product comprising particles of a water-insoluble macromolecular material selected from the group consisting of starch, dextrin and derivatives thereof which particles carry in cavities therein at least one non-radioactive paramagnetic metal species, said particles in aqueous media having particle sizes in the range of 6-200 micrometers, and generating an NMR or ultrasound image of said region.
Claim 5
Dependent Claim
19 words
A method according to claim 1 wherein said macromolecular product is administered suspended in a physiologically acceptable aqueous liquid.
Claim 6
Dependent Claim
18 words
A method according to claim 3 wherein said macromolecular product is administered together with a viscosity enhancing agent.
Claim 7
Dependent Claim
17 words
A method according to claim 3 wherein said macromolecular product is administered together with an osmolality regulator.
Claim 8
Dependent Claim
27 words
A method according to claim 2 wherein said non-radioactive paramagnetic metal is selected from the group consisting of elements having atomic numbers 21-29, 42, 44 and 57-70.
Claim 9
Dependent Claim
29 words
A method according to claim 6 wherein said non-radioactive paramagnetic metal is selected from the group consisting of gadolinium, erbium, europium, dysprosium, holmium, manganese, iron, nickel, chromium and copper.
Claim 10
Dependent Claim
12 words
A method according to claim 7 wherein said paramagnetic metal is gadolinium.
Claim 11
Dependent Claim
29 words
A method according to claim 1 wherein said non-radioactive metal species is in a water-insoluble or sparingly soluble substance at least partially filling said cavities in said macromolecular product.
Claim 12
Dependent Claim
30 words
A method according to claim 1 wherein said macromolecular product is in the form of water swellable particles which in their water-swollen state contain 10-98 percent by weight of water.
Claim 13
Dependent Claim
32 words
A method according to claim 1 wherein said macromolecular product is in the form of water swellable particles which in their water-swollen state have a particle size within the range 0.01-1000 μm.
Claim 14
Dependent Claim
17 words
A method according to claim 1 wherein said macromolecular product is material degradable in the animal body.
Claim 15
Dependent Claim
17 words
A method according to claim 12 wherein said macromolecular product is a material enzymatically degradable by hydrolases.
Claim 16
Dependent Claim
27 words
A method according to claim 1 wherein said non-radioactive paramagnetic metal is selected from the group consisting of elements having atomic numbers 21-29, 42, 44 and 57-70.
Claim 17
Dependent Claim
29 words
A method according to claim 14 wherein said non-radioactive paramagnetic metal is selected from the group consisting of gadolinium, erbium, europium, dysprosium, holmium, manganese, iron, nickel, chromium and copper.
Claim 18
Dependent Claim
18 words
A method according to claim 1 wherein said macromolecular product comprises a polysaccharide material or a derivative thereof.
Claim 19
Dependent Claim
20 words
A method according to claim 1 wherein said macromolecular product comprises a material selected from starches, dextrans and derivatives thereof.
Claim 20
Dependent Claim
17 words
A method according to claim 1 wherein said macromolecular product comprises a cellulose or a derivative thereof.
Claim 21
Dependent Claim
16 words
A method according to claim 12 wherein said macromolecular product is a material degradable by alpha-amylase.
Claim 22
Dependent Claim
23 words
A method according to claim 1 wherein said macromolecular product has a particle size of 0.1 to 3 microns when in aqueous media.
Claim 23
Independent Claim
11 words
A method according to claim wherein said paramagnetic metal is gadolinium.
Claim 24
Dependent Claim
17 words
A method according to claim 1 the particles whereof have no electrical charge when in aqueous suspension.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-14 | 1994-07-16 | 1995-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-14 | 1998-07-16 | 1999-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-14 | 2002-07-16 | 2003-01-15 | $7700.00 | Window Closed / Lapsed |