US4749560A
Expired / Lapsed
US
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Metal organo phosphorous compounds for NMR analysis
Assignee: Research Corp
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Filing: 1984-08-13
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Granted: 1988-06-07
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Expires: 2004-08-13
Abstract
Abstract The present invention relates to a class of compositions and a method for NMR imaging using an NMR signal affecting amount of a paramagnetic, diamagnetic or ferromagnetic metal ion chelated with an organo phosphorous compound. Gadolinium bis(bis-dihydroxyphosphonylmethylphosphinate) is an example of such a composition.
Inventors
- 👤 Gabriel A. Elgavish
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:24
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3821
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
180 words
A method for NMR analysis comprising administering to a host an NMR signal affecting amount of a complex of (a) a metal ion selected from a member of the group consisting of metal ions having atomic number 21 to 29 inclusive, 42 to 44 inclusive and the lanthanides having atomic numbers 57 to 70 inclusive, and (b) an organophosphorous metal ion chelating ligand comprising a phosphonylorgano phosphinate to form complexes of the formula: ##STR7## wherein n=2 to about 100; n 1 =the number of negative charges in n ##STR8## groups; a=1, 2, or 3; M=a metal ion described hereinabove; v=the valence of M; R 1 =O - or an organophosphenate comprising ##STR9## R=alkyl moiety, whether branched chain or straight chain, cyclic hydrocarbon moiety having from 3 to about 10 carbon atoms, said cyclic hydrocarbon moiety being saturated or unsaturated and including fused ring cyclic hydrocarbon moieties; heterocyclic hydrocarbon moieties having from 1 to 2 hetercyclic nitrogen, phosphorous, sulfur or oxygen atoms in said heterocyclic ring, said heterocyclic hydrocarbon moiety being saturated or unsaturated, and subjecting said host to NMR analysis.
Claim 2
Independent Claim
180 words
A method for NMR analysis comprising administering to a host an NMR signal affecting amount of a complex of (a) a metal ion selected from a member of the group consisting of metal ions having atomic number 21 to 29 inclusive, 42 to 44 inclusive and the lanthanides having atomic numbers 57 to 70 inclusive, and (b) an organophosphorous metal ion chelating ligand comprising a phosphonylorgano phosphinate to form complexes of the formula: ##STR7## wherein n=2 to about 100; n 1 =the number of negative charges in n ##STR8## groups; a=1, 2, or 3; M=a metal ion described hereinabove; v=the valence of M; R 1 =O - or an organophosphenate comprising ##STR9## R=alkyl moiety, whether branched chain or straight chain, cyclic hydrocarbon moiety having from 3 to about 10 carbon atoms, said cyclic hydrocarbon moiety being saturated or unsaturated and including fused ring cyclic hydrocarbon moieties; heterocyclic hydrocarbon moieties having from 1 to 2 hetercyclic nitrogen, phosphorous, sulfur or oxygen atoms in said heterocyclic ring, said heterocyclic hydrocarbon moiety being saturated or unsaturated, and subjecting said host to NMR analysis.
Claim 3
Dependent Claim
13 words
The method of claim 1 where said phosphinate ligand is a bis-dihydroxyphosphonyl-loweralkyl-phosphinic acid.
Claim 4
Dependent Claim
13 words
The method of claim 1 where said phosphinate ligand is a tris-dihydroxyphosphonyl-loweralkyl-phosphine oxide.
Claim 5
Dependent Claim
26 words
The method of claim 2 where said lower alkyl moiety includes straight chain or branched chain alkyl radicals having from 1 to about 3 carbon atoms.
Claim 6
Dependent Claim
26 words
The method of claim 3 where said lower alkyl moiety includes straight chain or branched chain alkyl radicals having from 1 to about 3 carbon atoms.
Claim 7
Dependent Claim
12 words
The method of claim 2 where said phosphorous compound is bis-dihydroxyphosphonylmethyl-phosphinic acid.
Claim 8
Dependent Claim
12 words
The method of claim 3 where said phosphorous compound is tris-dihydroxyphosphonylmethyl-phosphine oxide.
Claim 9
Dependent Claim
38 words
The method of claim 1 where said complex is a water soluble anionic coordination-complex of a metal ion selected from a member of the group consisting of the lanthanide metal ions having atomic numbers 57 to 70 inclusive.
Claim 10
Dependent Claim
54 words
The method of claim 1 where said ##STR10## where R is a lower alkyl moiety l, n, n l and v are defined previously and M is selected from a member of the group consisting of lanthanide metal ions, ions of the metals having atomic numbers 21 to 29 inclusive, 42 to 44 inclusive.
Claim 11
Dependent Claim
11 words
The method of claim 9 where R is a methyl moiety.
Claim 12
Dependent Claim
18 words
The method of claim 1 where said complex has the formula: ##STR11## where a 1, 2, or 3
Claim 13
Dependent Claim
12 words
The method of claim 1 where said host is a mammalian host.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-06-07 | 1991-12-07 | 1992-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-07 | 1995-12-07 | 1996-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-07 | 1999-12-07 | 2000-06-07 | $7700.00 | Window Closed / Lapsed |