US5318524A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fibrin sealant delivery kit
Assignee: Artivion Inc
•
Filing: 1992-03-02
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Granted: 1994-06-07
•
Expires: 2012-03-02
Abstract
Abstract The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.
Inventors
- 👤 Brenda S. Morse
- 👤 A. Denise Turner
- 👤 Robert T. McNally
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:50
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/00491; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; A61P; A61P7/00; A61P7/04; A61P9/00; A61B2017/00495; A61B17/22; A61B2017/22082
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
50 words
An applicator for use in the preparation of a fibrin sealant comprising a container means and an outlet means operably connected thereto, said container means having disposed therewithin a solution consisting essentially of fibrinogen, Factor XIII, mature thrombin and an agent that inhibits the clotting activity of said mature thrombin.
Claim 2
Dependent Claim
50 words
An applicator for use in the preparation of a fibrin sealant comprising a container means and an outlet means operably connected thereto, said container means having disposed therewithin a solution consisting essentially of fibrinogen, Factor XIII, mature thrombin and an agent that inhibits the clotting activity of said mature thrombin.
Claim 3
Dependent Claim
56 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a calcium chelator; and ii) an outlet means operably connected to said container means, wherein said outlet means has a calcium salt disposed therewithin.
Claim 4
Dependent Claim
56 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a calcium chelator; and ii) an outlet means operably connected to said container means, wherein said outlet means has a calcium salt disposed therewithin.
Claim 5
Dependent Claim
65 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII and mature thrombin, wherein said solution has a pH of less than about 5.5; and ii) an outlet means operably connected to said container means, wherein said outlet means has a neutralizing buffer salt disposed therewithin.
Claim 6
Dependent Claim
65 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII and mature thrombin, wherein said solution has a pH of less than about 5.5; and ii) an outlet means operably connected to said container means, wherein said outlet means has a neutralizing buffer salt disposed therewithin.
Claim 7
Dependent Claim
77 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a photosensitive inhibitor of thrombin clotting activity; and ii) an outlet means operably connected to said container means, wherein said container means and said outlet means are constructed of a material that does not transmit light of a wavelength to which said inhibitor is sensitive.
Claim 8
Dependent Claim
77 words
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises: i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a photosensitive inhibitor of thrombin clotting activity; and ii) an outlet means operably connected to said container means, wherein said container means and said outlet means are constructed of a material that does not transmit light of a wavelength to which said inhibitor is sensitive.
Claim 9
Dependent Claim
30 words
The kit according to claim 4 wherein said outlet means is attached to a source of light that, when activated, emits light at a wavelength that inactivates said photosensitive inhibitor.
Claim 10
Dependent Claim
18 words
The kit according to claim 4 wherein said solution further comprises a second inhibitor of thrombin clotting activity.
Claim 11
Dependent Claim
14 words
The kit according to claim 6 wherein said second inhibitor is D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone.
Claim 12
Dependent Claim
14 words
The kit according to claim 4 wherein said photosensitive inhibitor is a cinnamoyl derivative.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-06-06 | 1997-12-06 | 1998-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-06-06 | 2001-12-06 | 2002-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-06-06 | 2005-12-06 | 2006-06-07 | $7700.00 | Window Closed / Lapsed |