US5294446A
Expired / Lapsed
US
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Composition and method of promoting hard tissue healing
Assignee: Southwest Research Institute
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Filing: 1992-01-02
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Granted: 1994-03-15
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Expires: 2012-01-02
Abstract
Abstract Osteoprogenitor cells encapsulated in alginate and alternatively, additionally encapsulated in poly-L-lysine and/or agarose promote regeneration of bone at the site of implantation. The present invention provides a composition comprising osteoprogenitor cells embedded or encapsulated in alginate and the use of said microcapsules for the facilitation of bone regeneration.
Inventors
- 👤 Herman W. Schlameus
- 👤 William C. Fox
- 👤 Donald J. Mangold
- 👤 Robert G. Triplett
- 👤 George R. Holt
- 👤 Thomas B. Aufdemorte
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:32
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/04; A; A61; A61K; A61K35/00; A61K35/12; A61K35/32; A61K45/00; A61K45/06; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1652; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/50; A61L27/54; C12N5/00; C12N5/0012; C12N5/06; C12N5/0602; C12N5/0652; C12N5/0654; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/412; A61L2300/414; A61L2300/43; A61L2300/60; A61L2300/602; A61L2300/604; A61L2300/62; A61L2300/622; A61L2300/64; C12N2533/00; C12N2533/70; C12N2533/74
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
41 words
A composition of matter useful in facilitating osseous healing comprising osteoprogenitor cells and a bone inductive growth factor encapsulated in a biocompatible microcapsule made from a biodegradable polymer selected from the group consisting of alginate, poly-L-lysine and alginate coated with poly-L-lysine.
Claim 2
Dependent Claim
41 words
A composition of matter useful in facilitating osseous healing comprising osteoprogenitor cells and a bone inductive growth factor encapsulated in a biocompatible microcapsule made from a biodegradable polymer selected from the group consisting of alginate, poly-L-lysine and alginate coated with poly-L-lysine.
Claim 3
Dependent Claim
59 words
The composition of claim 1, wherein said bone inductive growth factors are selected from the group consisting of somatomedins, fibroblast growth factor, bone morphogenic protein, platelet derived growth factor, osteoinductive growth factor, cartilage derived growth factor, prostaglandins, macrophage derived growth factors, bone derived growth factor, skeletal derived growth factor, epidermal growth factor, transforming growth factor, growth factor and cytokines.
Claim 4
Dependent Claim
36 words
The composition of claim 1 further comprising a material selected from the group consisting of extra cellular matrix of chondrocytes (ECM), a hormone, an antiviral agent, an anti-inflammatory agent, an analgetic compound, and an antibacterial agent.
Claim 5
Dependent Claim
14 words
The composition of claim 1 wherein said microcapsule is contained in a hydrogel wafer.
Claim 6
Dependent Claim
24 words
The composition of claim 4 wherein said hydrogel wafer comprises a material selected from the group consisting of agar, gelatin, gellan gum and agarose.
Claim 7
Independent Claim
29 words
A method for promoting bone regeneration, comprising administration of the composition of any one of claims 1, 3, 4, and 5 to an individual in need of said treatment.
Claim 8
Dependent Claim
11 words
The method of claim 6 wherein said individual is a mammal.
Claim 9
Dependent Claim
24 words
The method of claim 7 wherein said mammal is selected from the group consisting of a human, a dog, a cat, and a horse.
Claim 10
Dependent Claim
11 words
The method of claim 7 wherein said mammal is a human.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-14 | 1997-09-13 | 1998-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-14 | 2001-09-13 | 2002-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-14 | 2005-09-13 | 2006-03-15 | $7700.00 | Window Closed / Lapsed |