US5242397A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
Assignee: Cedars-Sinai Medical Center
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Filing: 1992-01-02
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Granted: 1993-09-07
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Expires: 2012-01-02
Abstract
Abstract The present invention discloses a method of treatment of an atherosclerotic blood vessel. Protein kinase C and tyrosine protein kinase inhibitors are delivered by means of a specialized catheter system to the deeper layers of the vessel wall with only minimal interruption of the vessel endothelium. This system will allow high local concentrations of otherwise toxic agents directly at the site of an atherosclerotic plaque to prevent and/or reduce the incidence of late restenosis attributed to cellular hyperplasia or rethrombosis.
Inventors
- 👤 Peter Barath
- 👤 Ferenc Denes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:55
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; A61L; A61L29/00; A61L29/14; A61L29/16; A61M16/00; A61M16/04; A61M16/0475; A61M16/0477; A61M16/0481; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/432; A61L2300/434; A61M2025/1043; A61M2025/105; A61M2025/1086
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
141 words
A method of treating a blood vessel which contains an atherosclerotic lesion whereby a protein kinase C inhibitor agent is delivered into the vessel wall at or near the site of the atherosclerotic lesion comprising: insertion of a catheter device system into a diseased blood vessel, the catheter being one which contains an inflatable balloon studded with hollow tubular extensions that communicate between the outer surface of the balloon and the inner lumen of the catheter device system; slow filling of the catheter balloon so that the balloon surface's tubular extensions abut the inner vessel wall; and rapid infusion of a bolus of a protein kinase C inhibitor agent sufficient to effect bursting of the vessel's endothelium by the tubular extensions and delivery of the protein kinase C inhibitor agent to the deeper layers of the vessel wall through the extensions.
Claim 2
Independent Claim
141 words
A method of treating a blood vessel which contains an atherosclerotic lesion whereby a protein kinase C inhibitor agent is delivered into the vessel wall at or near the site of the atherosclerotic lesion comprising: insertion of a catheter device system into a diseased blood vessel, the catheter being one which contains an inflatable balloon studded with hollow tubular extensions that communicate between the outer surface of the balloon and the inner lumen of the catheter device system; slow filling of the catheter balloon so that the balloon surface's tubular extensions abut the inner vessel wall; and rapid infusion of a bolus of a protein kinase C inhibitor agent sufficient to effect bursting of the vessel's endothelium by the tubular extensions and delivery of the protein kinase C inhibitor agent to the deeper layers of the vessel wall through the extensions.
Claim 3
Dependent Claim
29 words
The method of claim 1 wherein the protein kinase C inhibitor agent is selected from the group consisting of H-7, H-8, TPA, tamoxifen, staurosporine, acridine derivatives, chlorpromazine and dibucaine.
Claim 4
Dependent Claim
17 words
The method of claim 2 wherein the protein kinase C inhibitor agent is bound to a macromolecule.
Claim 5
Independent Claim
142 words
A method of treating a blood vessel which contains an atherosclerotic lesion whereby a tyrosine protein kinase inhibitor agent is delivered into the vessel wall at or near the site of the atherosclerotic lesion comprising: insertion of a catheter device system into a diseased blood vessel, the catheter being one which contains an inflatable balloon studded with hollow tubular extensions that communicate between the outer surface of the balloon and the inner lumen of the catheter device system; slow filling of the catheter balloon so that the balloon surface's tubular extensions abut the inner vessel wall; and rapid infusion of a bolus of a tyrosine protein kinase inhibitor agent sufficient to effect bursting of the vessel's endothelium by the tubular extensions and delivery of a the tyrosine protein kinase inhibitor agent to the deeper layers of the vessel wall through the extensions.
Claim 6
Independent Claim
142 words
A method of treating a blood vessel which contains an atherosclerotic lesion whereby a tyrosine protein kinase inhibitor agent is delivered into the vessel wall at or near the site of the atherosclerotic lesion comprising: insertion of a catheter device system into a diseased blood vessel, the catheter being one which contains an inflatable balloon studded with hollow tubular extensions that communicate between the outer surface of the balloon and the inner lumen of the catheter device system; slow filling of the catheter balloon so that the balloon surface's tubular extensions abut the inner vessel wall; and rapid infusion of a bolus of a tyrosine protein kinase inhibitor agent sufficient to effect bursting of the vessel's endothelium by the tubular extensions and delivery of a the tyrosine protein kinase inhibitor agent to the deeper layers of the vessel wall through the extensions.
Claim 7
Dependent Claim
25 words
The method of claim 4 wherein the tyrosine protein kinase inhibitor agent is selected from the group consisting of herbimycin, ST 638, bioflavonoids and quercetin.
Claim 8
Dependent Claim
17 words
The method of claim 5 wherein the tyrosine protein kinase inhibitor agent is bound to a macromolecule.
Claim 9
Dependent Claim
155 words
A catheter device and system useful in the treatment of a blood vessel which contains an atherosclerotic lesion, said catheter comprising: a centrally hollow shaft having proximal and distal ends, said central portion comprising a first longitudinally extending lumen with an opening on its proximal end adapted to receive a protein kinase C inhibitor agent or a guide wire, and a second longitudinally extending lumen circumferentially disposed around and capable of communicating with the first longitudinally extending lumen and with a similarly adapted proximal end; a plurality of inflatable balloon type regions longitudinally and circumferentially disposed along the axis of said second longitudinally extending lumen and capable of communication with the protein kinase C inhibitor agent; a plurality of radially extending hollow tubular studs disposed along said inflatable regions extending outwardly from said catheter device and capable of communication with the protein kinase C inhibitor agent directly to either or both of the inner lumens.
Claim 10
Dependent Claim
155 words
A catheter device and system useful in the treatment of a blood vessel which contains an atherosclerotic lesion, said catheter comprising: a centrally hollow shaft having proximal and distal ends, said central portion comprising a first longitudinally extending lumen with an opening on its proximal end adapted to receive a protein kinase C inhibitor agent or a guide wire, and a second longitudinally extending lumen circumferentially disposed around and capable of communicating with the first longitudinally extending lumen and with a similarly adapted proximal end; a plurality of inflatable balloon type regions longitudinally and circumferentially disposed along the axis of said second longitudinally extending lumen and capable of communication with the protein kinase C inhibitor agent; a plurality of radially extending hollow tubular studs disposed along said inflatable regions extending outwardly from said catheter device and capable of communication with the protein kinase C inhibitor agent directly to either or both of the inner lumens.
Claim 11
Dependent Claim
34 words
The catheter device of claim 7 wherein the protein kinase C inhibitor agent received by the catheter is selected from the group consisting of H-7, H-8, TPA, tamoxifen, staurosporine, acridine derivatives, chlorpromazine and dibucaine.
Claim 12
Dependent Claim
18 words
The catheter device of claim 8 wherein the protein kinase C inhibitor agent is bound to a macromolecule.
Claim 13
Dependent Claim
155 words
A catheter device and system useful in the treatment of a blood vessel which contains an atherosclerotic lesion, said catheter comprising: a centrally hollow shaft having proximal and distal ends, said central portion comprising a first longitudinally extending lumen with an opening on its proximal end adapted to receive a tyrosine protein kinase inhibitor agent or a guide wire, and a second longitudinally extending lumen circumferentially disposed around and capable of communicating with the first longitudinally extending lumen and with a similarly adapted proximal end; a plurality of inflatable balloon type regions longitudinally and circumferentially disposed along the axis of said second longitudinally extending lumen and capable of communication with the tyrosine protein kinase inhibitor agent; a plurality of radially extending hollow tubular studs disposed along said inflatable regions extending outwardly from said catheter device and capable of communication with the tyrosine protein kinase inhibitor agent directly to either or both of the inner lumens.
Claim 14
Dependent Claim
155 words
A catheter device and system useful in the treatment of a blood vessel which contains an atherosclerotic lesion, said catheter comprising: a centrally hollow shaft having proximal and distal ends, said central portion comprising a first longitudinally extending lumen with an opening on its proximal end adapted to receive a tyrosine protein kinase inhibitor agent or a guide wire, and a second longitudinally extending lumen circumferentially disposed around and capable of communicating with the first longitudinally extending lumen and with a similarly adapted proximal end; a plurality of inflatable balloon type regions longitudinally and circumferentially disposed along the axis of said second longitudinally extending lumen and capable of communication with the tyrosine protein kinase inhibitor agent; a plurality of radially extending hollow tubular studs disposed along said inflatable regions extending outwardly from said catheter device and capable of communication with the tyrosine protein kinase inhibitor agent directly to either or both of the inner lumens.
Claim 15
Dependent Claim
30 words
The catheter device of claim 10 wherein the tyrosine protein kinase inhibitor agent received by the catheter is selected from the group consisting of herbimycin, ST 638, bioflavonoids and quercetin.
Claim 16
Dependent Claim
18 words
The catheter device of claim 11 wherein the tyrosine protein kinase inhibitor agent is bound to a macromolecule.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-06 | 1997-03-08 | 1997-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-06 | 2001-03-08 | 2001-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-06 | 2005-03-08 | 2005-09-07 | $7700.00 | Window Closed / Lapsed |