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US5236694A
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19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
Assignee: The University of Texas System
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Filing: 1990-02-21
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Granted: 1993-08-17
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Expires: 2010-02-21
Abstract
Abstract 19F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a 19F-containing sensor moiety, and a transport polymer or substrate, and can optionally also comprise a spacer moiety to separate the sensor moiety and the transport polymer.
Inventors
- 👤 Peter P. Antich
- 👤 Padmakar v. Kulkarni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:37
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/085; A61K49/14; A61K49/146; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
97 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising (a) a transport polymer selected from the group consisting of dextran polymers and aminodextrans, having a molecular weight between approximately 100 d and 500 kd, and antibodies and fragments thereof, and (b) a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 2
Independent Claim
97 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising (a) a transport polymer selected from the group consisting of dextran polymers and aminodextrans, having a molecular weight between approximately 100 d and 500 kd, and antibodies and fragments thereof, and (b) a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 3
Independent Claim
90 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising a transport polymer selected from the group consisting of dextran polymers and aminodextrans, having a molecular weight between approximately 100 d and 500 kd, and a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 4
Independent Claim
90 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising a transport polymer selected from the group consisting of dextran polymers and aminodextrans, having a molecular weight between approximately 100 d and 500 kd, and a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 5
Independent Claim
87 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising a transport polymer selected from the group consisting of antibodies and fragments thereof capable of recognizing a tissue specific antigenic marker, and a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 6
Independent Claim
87 words
A method of NMR imaging or spectroscopy, comprising the steps of administering to a living subject a 19 F labelled NMR agent, the NMR agent comprising a transport polymer selected from the group consisting of antibodies and fragments thereof capable of recognizing a tissue specific antigenic marker, and a 19 F-containing sensor moiety selected from the group consisting of fluorinated alkyls, fluorinated acetates, fluoroaniline, and fluoroalkyl phosphonates, in an amount effective to provide a detectable NMR signal; and then detecting the 19 F NMR signal produced thereby.
Claim 7
Dependent Claim
64 words
The method of claim 1, 2, or 3, where the 19 F labelled NMR agent further comprises a spacer moiety having from approximately 1-100 carbon atoms, selected from the group consisting of alkyl, alkoxy, aryl, and alkaryl hydrocarbons which contain an amino group, hydrazine, hydrazide, semicarbazide, and hydroxylamine, with the 19 F-containing sensor moiety and transport polymer being separately attached to the spacer moiety.
Claim 8
Dependent Claim
25 words
The method of claim 1, 2, or 3, further comprising the step of using the detected 19 F NMR signal for vascular or tumor imaging.
Claim 9
Dependent Claim
23 words
The method of claim 1, 2, or 3, further comprising the step of using the detected 19 F NMR signal for lesion detection.
Claim 10
Dependent Claim
28 words
The method of claim 1, 2, or 3, further comprising the step of using the detected 19 F NMR signal for measuring pH of tissue of the subject.
Claim 11
Dependent Claim
29 words
The method of claim 1, 2, or 3, further comprising the step of using the detected 19 F NMR signal for measuring oxygen content of tissue of the subject.
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