EP0186947A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Paramagnetic contrast agents for use in "in vivo" diagnostic methods using NMR, and their preparation
Assignee: GE Healthcare AS
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Filing: 1985-10-25
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Granted: —
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Expires: 2005-10-25
Abstract
Abstract 57 There is disclosed a diagnostic agent containing a non-radioactive paramagnetic metal species which agent comprises a physiologically tolerable, watersoluble, hydroxyl group-containing macromolecular product to which is chemically bound said metal species, said product consisting essentially of at least one polymeric or polymerized carbohydrate or polymerized sugar alcohol or derivative thereof.
Inventors
- 👤 Trond Jacobsen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 11:10
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/085; A61K49/10; A61K49/12; A61K49/126; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
60 words
A diagnostic agent containing a non-radioactive paramagnetic metal species, characterized in that said agent comprises a physiologically tolerable, water-soluble, hydroxyl group-containing, macromolecular product to which is chemically bound at least one non-radioactive paramagnetic metal species, said macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
Claim 2
Dependent Claim
60 words
A diagnostic agent containing a non-radioactive paramagnetic metal species, characterized in that said agent comprises a physiologically tolerable, water-soluble, hydroxyl group-containing, macromolecular product to which is chemically bound at least one non-radioactive paramagnetic metal species, said macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
Claim 3
Dependent Claim
22 words
A diagnostic agent according to claim 1 wherein the average molecular weight (M ) of said macromolecular product is at least 1000.
Claim 4
Dependent Claim
23 words
A diagnostic agent according to either of claims 1 and 2 wherein said macromolecular product is a material degradable in the animal body.
Claim 5
Dependent Claim
17 words
A diagnostic agent according to claim 3 wherein said macromolecular product is a material degradable by hydrolases.
Claim 6
Dependent Claim
33 words
5 A diagnostic agent according to any one of claims 1 to 4 wherein said non-radioactive paramagnetic metal is selected from the group of elements having atomic numbers 21-29, 42, 44 and 57-70.
Claim 7
Dependent Claim
31 words
6 A diagnostic agent according to claim 5 wherein said non-radioactive paramagnetic metal is selected from the group consisting of gadolinium, erbium, europium, dysprosium, holmium, manganese, iron, nickel, chromium and copper.
Claim 8
Dependent Claim
32 words
A diagnostic agent according to any one of claims 1 to 6 wherein said non-radioactive paramagnetic metal species is chemically bound to said macromolecular product in the form of a chelate complex.
Claim 9
Dependent Claim
21 words
A diagnostic agent according to any one of claims 1 to 7 further comprising at least one pharmaceutical carrier or excipient.
Claim 10
Dependent Claim
20 words
A diagnostic agent according to claim 8 in solution form further comprising a viscosity enhancing agent and/or an osmolality regulator.
Claim 11
Independent Claim
59 words
A method of producing an image capable of use in diagnosis which method comprises administering to a human or non-human animal body or to a selected region thereof a diagnostically effective amount of a diagnostic agent as claimed in any one of claims 1 to 9 and generating an NMR or ultrasound image of said body or said region.
Claim 12
Dependent Claim
72 words
A process for the preparation of a water-soluble paramagnetic metal species -containing macromolecular material comprising chemically binding a non-radioactive paramagnetic species to a physiologically tolerable, water-soluble, hydroxyl group-containing macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof, optionally following the chemical bonding to said macromolecular product of a chelate-forming group capable of complexing said paramagnetic metal species.
Claim 13
Dependent Claim
72 words
A process for the preparation of a water-soluble paramagnetic metal species -containing macromolecular material comprising chemically binding a non-radioactive paramagnetic species to a physiologically tolerable, water-soluble, hydroxyl group-containing macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof, optionally following the chemical bonding to said macromolecular product of a chelate-forming group capable of complexing said paramagnetic metal species.
Claim 14
Dependent Claim
74 words
A process for preparing a diagnostic agent containing a non-radioactive paramagnetic metal species, characterised in that said process comprises admixing with at least one pharmaceutical carrier or excipient a physiologically tolerable, water soluble, hydroxyl group-containing macromolecular product to which is chemically bound at least one non-radioactive paramagnetic metal species, said macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
Claim 15
Dependent Claim
74 words
A process for preparing a diagnostic agent containing a non-radioactive paramagnetic metal species, characterised in that said process comprises admixing with at least one pharmaceutical carrier or excipient a physiologically tolerable, water soluble, hydroxyl group-containing macromolecular product to which is chemically bound at least one non-radioactive paramagnetic metal species, said macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
Claim 16
Dependent Claim
60 words
The use for the manufacture of a diagnostic agent for use in a method of diagnosis practised on the human or animal body of a non-radioactive paramagnetic metal species and a physiologically tolerable, water-soluble, hydroxyl group-containing macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
Claim 17
Dependent Claim
60 words
The use for the manufacture of a diagnostic agent for use in a method of diagnosis practised on the human or animal body of a non-radioactive paramagnetic metal species and a physiologically tolerable, water-soluble, hydroxyl group-containing macromolecular product comprising at least one material selected from the group consisting of polymeric and polymerized carbohydrates and polymerized sugar alcohols and derivatives thereof.
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