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US5230882A
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US
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Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1992-01-08
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Granted: 1993-07-27
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Expires: 2012-01-08
Abstract
Abstract Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:29
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/227; A61K41/00; A61K41/0028; A61K41/0052; A61K49/223; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; A61K9/1278
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
17 words
A contrast agent for ultrasonic imaging which comprises a liposome having encapsulated therein a photo-activated gaseous precursor.
Claim 2
Dependent Claim
17 words
A contrast agent for ultrasonic imaging which comprises a liposome having encapsulated therein a photo-activated gaseous precursor.
Claim 3
Dependent Claim
15 words
A contrast agent according to claim 1 wherein said photo-activated precursor is a diazonium compound.
Claim 4
Dependent Claim
17 words
A contrast agent for ultrasonic imaging which comprises a liposome having encapsulated therein a temperature-activated gaseous precursor.
Claim 5
Dependent Claim
17 words
A contrast agent for ultrasonic imaging which comprises a liposome having encapsulated therein a temperature-activated gaseous precursor.
Claim 6
Dependent Claim
14 words
A contrast agent according to claim 3 wherein said temperature-activated gaseous precursor is methyllactate.
Claim 7
Dependent Claim
44 words
A contrast agent according to claim 1 wherein the liposome is comprised of lipid selected from the group consisting of fatty acids, lysolipids, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, phosphatidylinositol, sphingomyelin, lysolipids, cholesterol, cholesterol hemisuccinate, glycosphingolipids, glycolipids, glucolipids, sulphatides, and tocopherol hemisuccinate.
Claim 8
Dependent Claim
14 words
A contrast agent according to claim 5 wherein the liposome is comprised of phosphatidylcholine.
Claim 9
Dependent Claim
16 words
A contrast agent according to claim 5 wherein the liposome is comprised of cholesterol and phosphatidylcholine.
Claim 10
Dependent Claim
24 words
A contrast agent according to claim 1 wherein the liposome has a mean outer diameter of between about 30 nanometers and about 2 microns.
Claim 11
Dependent Claim
24 words
A contrast agent according to claim 1 wherein the liposome has a mean outer diameter of between about 2 microns and about 10 microns.
Claim 12
Dependent Claim
44 words
A contrast agent according to claim 3 wherein the liposome is comprised of lipids selected from the group consisting of fatty acids, lysolipids, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, phosphatidylinositol, shpingomyelin, lysolipids, cholesterol, cholesterol hemisuccinate, glycosphingolipids, glycolipids, glucolipids, sulphatides, and tocopherol hemisuccinate.
Claim 13
Dependent Claim
14 words
A contrast agent according to claim 10 wherein the liposome is comprised of phosphatidylcholine.
Claim 14
Dependent Claim
16 words
A contrast agent according to claim 10 wherein the liposome is comprised of cholesterol and phosphatidylcholine.
Claim 15
Dependent Claim
24 words
A contrast agent according to claim 3 wherein the liposome has a mean outer diameter of between about 30 nanometers and about two microns.
Claim 16
Dependent Claim
24 words
A contrast agent according to claim 3 wherein the liposome has a mean outer diameter of between about 2 microns and about 10 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-26 | 1997-01-25 | 1997-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-26 | 2001-01-25 | 2001-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-26 | 2005-01-25 | 2005-07-27 | $7700.00 | Window Closed / Lapsed |