US4938947A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aerosol composition for in vivo imaging
Assignee: Centre National de la Recherche Scientifique
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Filing: 1988-01-04
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Granted: 1990-07-03
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Expires: 2008-01-04
Abstract
Abstract The present invention relates to an aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial wall or cell peptidoglycan or equivalent synthetic compounds which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.
Inventors
- 👤 Yves-Claude Nicolau
- 👤 Alain Le Pape
- 👤 Rita Barot-Ciorbaru
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K51/00; A61K51/12; A61K51/1217; A61K51/1231; A61K51/1234; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
53 words
Aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial cell peptidoglycan of Nocardia derivatives (NSPD) which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.
Claim 2
Dependent Claim
53 words
Aerosol composition for in vivo imaging or ex vivo diagnosis of tumors, which composition contains one or more soluble fragments of bacterial cell peptidoglycan of Nocardia derivatives (NSPD) which are labelled with a radioactive, paramagnetic or fluorescent element and encapsulated in liposomes and a substrate which can be used for administration by aerosol.
Claim 3
Dependent Claim
23 words
Composition as claimed in claim 1, wherein the NSPD is labelled with 99m technetium or with another emitter detectable by scintigraphy or counting.
Claim 4
Dependent Claim
15 words
Composition as claimed in claim 1, wherein the NSPD is labelled with a paramagnetic probe.
Claim 5
Dependent Claim
15 words
Composition as claimed in claim 1, wherein the NSPD is labelled with a fluorescent probe.
Claim 6
Dependent Claim
32 words
Composition as claimed in claim 1, wherein the liposome consists of at least one lipid having substantial surfactant properties with respect to cell tissue and is thus readily emulsifiable in cell tissue.
Claim 7
Dependent Claim
13 words
Composition as claimed in claim 5, wherein the liposome is a phosphatidylcholine/phosphatidylserine/cholesterol liposome.
Claim 8
Dependent Claim
18 words
Composition as claimed in claim 6, wherein the mole ratio of the components of the liposome is 4:1:5.
Claim 9
Dependent Claim
26 words
Composition as claimed in claim 1, wherein the NSPD is in combination with one or more products possessing substantial surfactant properties with respect to cell tissue.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-07-02 | 1994-01-01 | 1994-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-02 | 1998-01-01 | 1998-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-02 | 2002-01-01 | 2002-07-03 | $7700.00 | Window Closed / Lapsed |