US5213809A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Delivery system comprising means for controlling internal pressure
Assignee: Alza Corp
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Filing: 1992-03-12
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Granted: 1993-05-25
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Expires: 2012-03-12
Abstract
Abstract A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
Inventors
- 👤 Jeremy C. Wright
- 👤 James B. Eckenhoff
- 👤 Frederick H. Maruyama
- 👤 John R. Peery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
134 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises: a) mixing a viscosity-inducing amount of an inert viscosity-inducing agent into the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition, and b) positioning a pressure-inducing exit member in the exit opening in the wall of the dispense, whereby steps a) and b) increase the internal pressure of the dispenser.
Claim 2
Dependent Claim
134 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises: a) mixing a viscosity-inducing amount of an inert viscosity-inducing agent into the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition, and b) positioning a pressure-inducing exit member in the exit opening in the wall of the dispense, whereby steps a) and b) increase the internal pressure of the dispenser.
Claim 3
Dependent Claim
21 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the viscosity-inducing agent is silicon dioxide.
Claim 4
Dependent Claim
43 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the viscosity-inducing agent is selected from the group consisting of silica, sand, precipitated silica, amorphous silica, colloidal silicon dioxide, fused silica, quartz, silica gel, and a siliceous composition.
Claim 5
Dependent Claim
31 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the process comprises positioning a releaseable pressure-inducing exit member in the exit opening in the wall.
Claim 6
Dependent Claim
33 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the exit member is an insert for placement in the exit opening in the wall of the dispenser.
Claim 7
Dependent Claim
35 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the exit member is selected from a grid, a perforated plate, a plurality of capillaries, and a plurality of tubes.
Claim 8
Dependent Claim
35 words
A process for increasing the internal pressure of a dispenser according to claim 5 wherein the exit member is selected from a grid, a perforated plate, a plurality of capillaries, and a plurality of tubes.
Claim 9
Dependent Claim
22 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the beneficial agent is avermectin or ivermectin.
Claim 10
Dependent Claim
30 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the push means comprises an osmagent, an osmopolymer or an osmagnet together with an osmopolymer.
Claim 11
Dependent Claim
33 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the dispenser further comprises an inert partition in the lumen between the thermo-responsive composition and the push means.
Claim 12
Dependent Claim
37 words
A process for increasing the internal pressure of a dispenser according to claim 1 wherein the density member comprises a weight with a bore in the weight, and the exit member is in contact with the bore.
Claim 13
Dependent Claim
113 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises; a) mixing a viscosity-inducing amount of an inert viscosity-inducing agent into the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition to increase the internal pressure of the dispenser.
Claim 14
Dependent Claim
113 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises; a) mixing a viscosity-inducing amount of an inert viscosity-inducing agent into the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition to increase the internal pressure of the dispenser.
Claim 15
Dependent Claim
21 words
A process for increasing the internal pressure of a dispenser according to claim 12 wherein the viscosity-inducing agent is silicon dioxide.
Claim 16
Dependent Claim
43 words
A process for increasing the internal pressure of a dispenser according to claim 12 wherein the viscosity-inducing agent is selected from the group consisting of silica, sand, precipitated silica, amorphous silica, colloidal silicon dioxide, fused silica, quartz, silica gel, and a siliceous composition.
Claim 17
Dependent Claim
27 words
A process for increasing the internal pressure of a dispenser according to claim 12 wherein the viscosity-inducing agent increases the stress to flow of the thermo-responsive composition.
Claim 18
Dependent Claim
107 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises: a) positioning a pressure-inducing exit member in the exit opening in the wall of the dispenser to increase the internal pressure of the dispenser.
Claim 19
Dependent Claim
107 words
A process for increasing the internal pressure of a dispenser, wherein the dispenser comprises: i) a wall that surrounds a lumen, ii) a thermo-responsive composition in the lumen, iii) a beneficial agent mixed with the thermo-responsive composition, iv) optionally, a density member in the lumen for increasing the weight of the dispenser, v) push means in the lumen for displacing the thermo-responsive composition from the dispenser, and vi) an exit opening in the wall that communicates with the lumen; wherein, the process comprises: a) positioning a pressure-inducing exit member in the exit opening in the wall of the dispenser to increase the internal pressure of the dispenser.
Claim 20
Dependent Claim
31 words
A process for increasing the internal pressure of a dispenser according to claim 16 wherein the process comprises positioning a releasable pressure-inducing exit member in the exit opening in the wall.
Claim 21
Dependent Claim
33 words
A process for increasing the internal pressure of a dispenser according to claim 16 wherein the exit member is an insert for placement in the exit opening in the wall of the dispenser.
Claim 22
Dependent Claim
35 words
A process for increasing the internal pressure of a dispenser according to claim 16 wherein the exit member is selected from a grid, a perforated plate, a plurality of capillaries, and a plurality of tubes.
Claim 23
Dependent Claim
35 words
A process for increasing the internal pressure of a dispenser according to claim 18 wherein the exit member is selected from a grid, a perforated plate, a plurality of capillaries, and a plurality of tubes.
References Cited (Backward Citations)
US3995632A
Cited
EP0031043A1
Cited
US4564363A
Cited
US5000957A
Cited
US4612186A
Cited
US4595583A
Cited
US4663148A
Cited
US4678467A
Cited
US4692326A
Cited
US4814180A
Cited
US4716031A
Cited
US4800056A
Cited
US4729793A
Cited
US4772474A
Cited
US4643731A
Cited
US4704118A
Cited
US4968508A
Cited
US4876093A
Cited
US4872873A
Cited
US5045082A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-24 | 1996-11-23 | 1997-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-24 | 2000-11-23 | 2001-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-24 | 2004-11-23 | 2005-05-25 | $7700.00 | Window Closed / Lapsed |