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US4876093A Expired / Lapsed US ⏱️ 0.0 years remaining

Dispenser with dispersing member for delivering beneficial agent

Assignee: Alza Corp
•
Filing: 1987-07-02
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Granted: 1989-10-24
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Expires: 2007-07-02
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Abstract

Abstract A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising carrier means for housing a beneficial agent, push means for pushing the carrier means from the dispenser and fragmenting means for fragmenting the carrier means as it is pushed from the dispenser.

Inventors

  • 👤 Felix Theeuwes
  • 👤 Patrick S. L. Wong

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 15:48
CPC Classifications
A; A61; A61M; A61M31/00; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M31/002

Claims Analysis

Total Claims: 27
Claim 1
Independent Claim 157 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the carrier means for administering a beneficial agent; (d) pushing means for occupying an increasing amount of space in the lumen for pushing the carrier means comprising the beneficial agent from the dispenser; and, (e) a mouth in the dispenser comprising means for breaking the carrier means from a first size to a second size as the carrier means leaves the dispenser.
Claim 2
Dependent Claim 157 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser; (c) a beneficial agent in the carrier means for administering a beneficial agent; (d) pushing means for occupying an increasing amount of space in the lumen for pushing the carrier means comprising the beneficial agent from the dispenser; and, (e) a mouth in the dispenser comprising means for breaking the carrier means from a first size to a second size as the carrier means leaves the dispenser.
Claim 3
Dependent Claim 33 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent comprises hydrophobic composition.
Claim 4
Dependent Claim 34 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent comprises a hydrophilic composition.
Claim 5
Dependent Claim 37 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent bioerodes in an animal environment of use.
Claim 6
Dependent Claim 42 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent is delivered from the dispenser and is hydrolyzed in the animal environment.
Claim 7
Dependent Claim 42 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent is delivered from the dispenser and is solubilized in the animal environment.
Claim 8
Dependent Claim 35 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent dissolves in an animal environment.
Claim 9
Dependent Claim 35 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent disintegrates in the animal environment.
Claim 10
Dependent Claim 45 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means administers the beneficial agent by at least one process comprising diffusion, osmosis, osmotic bursting, solution leaching, solubilization, hydrolysis, enzymatic digestion, displacement and dissolution.
Claim 11
Dependent Claim 27 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a ruminant.
Claim 12
Dependent Claim 27 words
The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a human.
Claim 13
Dependent Claim 187 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of he dispenser; (c) a beneficial agent in the carrier means; (d) push means for occupying an increasing amount of space in the lumen for pushing the carrier means for administering a beneficial agent from the dispenser; (e) dense means in the lumen for maintaining the dispenser in the animal environment of use over time; and (f) an opening in the wall of the dispenser for communicating the carrier means for administering the beneficial agent with the environment of use, said opening comprising means for breaking the carrier means into smaller carrier means as the carrier means leaves the dispenser.
Claim 14
Dependent Claim 187 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of he dispenser; (c) a beneficial agent in the carrier means; (d) push means for occupying an increasing amount of space in the lumen for pushing the carrier means for administering a beneficial agent from the dispenser; (e) dense means in the lumen for maintaining the dispenser in the animal environment of use over time; and (f) an opening in the wall of the dispenser for communicating the carrier means for administering the beneficial agent with the environment of use, said opening comprising means for breaking the carrier means into smaller carrier means as the carrier means leaves the dispenser.
Claim 15
Dependent Claim 153 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means maintaining its physical and chemical integrity while the carrier means is in the lumen of the dispenser; (c) a beneficial agent formulation in the carrier means; (d) expandable means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said expandable means comprising a hydrophilic polymeric composition; and, (e) a mouth in the dispenser comprising means for fragmenting the carrier means from its lumen size to a different size as it leaves the dispenser.
Claim 16
Dependent Claim 153 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent; (b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means maintaining its physical and chemical integrity while the carrier means is in the lumen of the dispenser; (c) a beneficial agent formulation in the carrier means; (d) expandable means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said expandable means comprising a hydrophilic polymeric composition; and, (e) a mouth in the dispenser comprising means for fragmenting the carrier means from its lumen size to a different size as it leaves the dispenser.
Claim 17
Dependent Claim 22 words
The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is serrated.
Claim 18
Dependent Claim 22 words
The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is saw-toothed.
Claim 19
Dependent Claim 23 words
The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is a screen.
Claim 20
Dependent Claim 24 words
The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means comprises a cutting edge.
Claim 21
Dependent Claim 32 words
The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means comprises at least one string formed of naturally occurring or synthetic materials.
Claim 22
Dependent Claim 141 words
A dispenser for administering beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid; (b) carrier means in the lumen for containing a beneficial agent formulation, said carrier means keeping its physical and chemical integrity while the carrier means is in the lumen; (c) a beneficial agent formulation in the carrier means; (d) solution means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said solution means comprising an osmagent that imbibes fluid into the lumen and forms a solution; and, (e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.
Claim 23
Dependent Claim 141 words
A dispenser for administering beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid; (b) carrier means in the lumen for containing a beneficial agent formulation, said carrier means keeping its physical and chemical integrity while the carrier means is in the lumen; (c) a beneficial agent formulation in the carrier means; (d) solution means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said solution means comprising an osmagent that imbibes fluid into the lumen and forms a solution; and, (e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.
Claim 24
Dependent Claim 120 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid; (b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means keeping its physical integrity in the lumen; (c) a beneficial agent formulation in the carrier means; (d) gas generating means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen; and, (e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.
Claim 25
Dependent Claim 120 words
A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising: (a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid; (b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means keeping its physical integrity in the lumen; (c) a beneficial agent formulation in the carrier means; (d) gas generating means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen; and, (e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.
Claim 26
Independent Claim 125 words
A method for delivering a beneficial agent to an animal, wherein the method comprises: (a) admitting into an animal a dispensing device comprising: (1) a wall; (2) a lume defined by the wall; (3) a solid matrix in the lumen, which matrix comprises compositional means keeping its physical and chemical integrity while in the lumen; (4) a beneficial agent in the matrix; (5) an opening in the wall; (6) means in the opening for changing the matrix from a first size to a second size; (7) means in the lumen for pushing the matrix through the opening; (b) pushing the matrix through the opening for changing it from a first to a second size; thereby, (c) delivering the beneficial agent to the animal over time.
Claim 27
Independent Claim 125 words
A method for delivering a beneficial agent to an animal, wherein the method comprises: (a) admitting into an animal a dispensing device comprising: (1) a wall; (2) a lume defined by the wall; (3) a solid matrix in the lumen, which matrix comprises compositional means keeping its physical and chemical integrity while in the lumen; (4) a beneficial agent in the matrix; (5) an opening in the wall; (6) means in the opening for changing the matrix from a first size to a second size; (7) means in the lumen for pushing the matrix through the opening; (b) pushing the matrix through the opening for changing it from a first to a second size; thereby, (c) delivering the beneficial agent to the animal over time.

References Cited (Backward Citations)

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-10-23 1993-04-24 1993-10-24 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-10-23 1997-04-24 1997-10-24 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-10-23 2001-04-24 2001-10-24 $7700.00 Window Closed / Lapsed

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