Patent US5211849A successfully refreshed from Google Patents.
US5211849A
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US
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Hemofiltration system and method
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1991-10-11
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Granted: 1993-05-18
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Expires: 2011-10-11
Abstract
Abstract A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.
Inventors
- 👤 Yuli Kitaevich
- 👤 Nat Hemasilpin
- 👤 J. Gabriel Marchevsky
- 👤 John J. Bissler
- 👤 George Benzing, III
- 👤 Paul T. McEnery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:19
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1621; A61M1/1643; A61M1/34; A61M1/3403; A61M1/341; A61M1/342; A61M1/3424; A61M1/3427; A61M1/3441; A61M1/3451; A61M1/36; A61M1/3607; A61M1/3621; A61M1/3623; A61M2205/00; A61M2205/15; A61M2205/33; A61M2205/3331; A61M2205/3334; A61M2205/3344; A61M2205/3368; A61M2205/3379; A61M2205/3393; A61M2205/50; Y; Y10; Y10S; Y10S210/00; Y10S210/929
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
262 words
Continuous hemofiltration system for removal of fluid from the blood of a patient, comprising: hemofiltration means; means for pumping blood from a patient through said hemofiltration means and back to the patient; a first reservoir for maintaining a supply of infusate; a first weighing means for monitoring the weight of the infusate and generating signals correlated thereto; first pumping means for pumping the infusate from said first reservoir to said hemofiltration means; a second reservoir for receiving drained fluid from said hemofiltration means; a second weighing means for monitoring the weight of the drained fluid and generating signals correlated thereto; second pumping means for pumping the drained fluid from said hemofiltration means to said second reservoir; control means operably connected to said blood pumping means and to each of said first and second pumping means and said first and second weighing means, said control means comprising a computer programmed to operate said first and second pumping means only when said blood pumping means is operating; said blood pumping means being responsive to signals generated by said control means to vary the flow rate of the blood through said hemofiltration means; and said control means being responsive to said signals generated by said first and second weighing means and determining the weight of infusate and drained fluid in said first and second reservoirs, respectively, at regular intervals, comparing those weights to corresponding predetermined computed weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood over a preselected time period.
Claim 2
Dependent Claim
262 words
Continuous hemofiltration system for removal of fluid from the blood of a patient, comprising: hemofiltration means; means for pumping blood from a patient through said hemofiltration means and back to the patient; a first reservoir for maintaining a supply of infusate; a first weighing means for monitoring the weight of the infusate and generating signals correlated thereto; first pumping means for pumping the infusate from said first reservoir to said hemofiltration means; a second reservoir for receiving drained fluid from said hemofiltration means; a second weighing means for monitoring the weight of the drained fluid and generating signals correlated thereto; second pumping means for pumping the drained fluid from said hemofiltration means to said second reservoir; control means operably connected to said blood pumping means and to each of said first and second pumping means and said first and second weighing means, said control means comprising a computer programmed to operate said first and second pumping means only when said blood pumping means is operating; said blood pumping means being responsive to signals generated by said control means to vary the flow rate of the blood through said hemofiltration means; and said control means being responsive to said signals generated by said first and second weighing means and determining the weight of infusate and drained fluid in said first and second reservoirs, respectively, at regular intervals, comparing those weights to corresponding predetermined computed weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood over a preselected time period.
Claim 3
Dependent Claim
54 words
The hemodialysis system of claim 1 wherein said hemofiltration means includes a hemofilter, input tubing through which blood is pumped to said hemofilter, output tubing through which blood is pumped from said hemofilter, feed tubing connecting said first pumping means to said hemofilter, and drain tubing connecting said second pumping means to said hemofilter.
Claim 4
Dependent Claim
64 words
The hemodialysis system of claim 2 further comprising: first pressure monitoring means for monitoring the pressure in said input tubing to said hemofilter; second pressure monitoring means for monitoring the pressure in said output tubing; third pressure monitoring means for monitoring the pressure in said drain tubing; and fourth pressure monitoring means for monitoring the pressure in said input tubing to said blood pump.
Claim 5
Dependent Claim
26 words
The hemodialysis system of claim 1 further comprising means for adding an anti-clotting medication to the blood prior to pumping the blood through said hemofiltration means.
Claim 6
Dependent Claim
261 words
Continuous hemofiltration system for removal of fluid from the blood of a patient, comprising: hemofiltration means; means for pumping blood from a patient through said hemofiltration means and back to the patient; a first reservoir for maintaining a supply of infusate; a first weighing means for monitoring the weight of the infusate and generating signals correlated thereto; first pumping means for pumping the infusate from said first reservoir to the patient; a second reservoir for receiving drained fluid from said hemofiltration means; a second weighing means for monitoring the weight of the drained fluid and generating signals correlated thereto; second pumping means for pumping the drained fluid from said hemofiltration means to said second reservoir; control means operably connected to said blood pumping means and to each of said first and second pumping means and said first and second weighing means, said control means comprising a computer programmed to operate said first and second pumping means only when said blood pumping means is operating; said blood pumping means being responsive to signals generated by said control means to vary the flow rate of the blood through said hemofiltration means; and said control means being responsive to said signals generated by said first and second weighing means and determining the weight of infusate and drained fluid in said first and second reservoirs, respectively, at regular intervals, comparing those weights to corresponding predetermined computed weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood over a preselected time period.
Claim 7
Dependent Claim
261 words
Continuous hemofiltration system for removal of fluid from the blood of a patient, comprising: hemofiltration means; means for pumping blood from a patient through said hemofiltration means and back to the patient; a first reservoir for maintaining a supply of infusate; a first weighing means for monitoring the weight of the infusate and generating signals correlated thereto; first pumping means for pumping the infusate from said first reservoir to the patient; a second reservoir for receiving drained fluid from said hemofiltration means; a second weighing means for monitoring the weight of the drained fluid and generating signals correlated thereto; second pumping means for pumping the drained fluid from said hemofiltration means to said second reservoir; control means operably connected to said blood pumping means and to each of said first and second pumping means and said first and second weighing means, said control means comprising a computer programmed to operate said first and second pumping means only when said blood pumping means is operating; said blood pumping means being responsive to signals generated by said control means to vary the flow rate of the blood through said hemofiltration means; and said control means being responsive to said signals generated by said first and second weighing means and determining the weight of infusate and drained fluid in said first and second reservoirs, respectively, at regular intervals, comparing those weights to corresponding predetermined computed weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood over a preselected time period.
Claim 8
Dependent Claim
198 words
Hemofiltration method for removal of fluid from the blood of a patient, comprising: pumping blood from a patient through hemofiltration means and back to the patient; maintaining a supply of infusate in a first reservoir; pumping the infusate to the hemofiltration means; monitoring the weight of the infusate and generating signals correlated thereto; pumping drained fluid from the hemofiltration means into a second reservoir; monitoring the weight of the drained fluid and generating signals correlated thereto; controlling the pumping of the blood, infusate and drained fluid by means of a computer programmed to operate the pumps for infusate and drained fluid only when he blood is being pumped, said computer being responsive to the infusate and drained fluid weight signals; said blood pumping operation being responsive to signals generated by said computer to vary the flow rate of the blood through the hemofiltration means; and determining, at regular intervals, the weight of infusate in the first reservoir and the weight of drained fluid in the second reservoir, comparing those weights to corresponding predetermined ideal weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood.
Claim 9
Dependent Claim
198 words
Hemofiltration method for removal of fluid from the blood of a patient, comprising: pumping blood from a patient through hemofiltration means and back to the patient; maintaining a supply of infusate in a first reservoir; pumping the infusate to the hemofiltration means; monitoring the weight of the infusate and generating signals correlated thereto; pumping drained fluid from the hemofiltration means into a second reservoir; monitoring the weight of the drained fluid and generating signals correlated thereto; controlling the pumping of the blood, infusate and drained fluid by means of a computer programmed to operate the pumps for infusate and drained fluid only when he blood is being pumped, said computer being responsive to the infusate and drained fluid weight signals; said blood pumping operation being responsive to signals generated by said computer to vary the flow rate of the blood through the hemofiltration means; and determining, at regular intervals, the weight of infusate in the first reservoir and the weight of drained fluid in the second reservoir, comparing those weights to corresponding predetermined ideal weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood.
Claim 10
Dependent Claim
26 words
The method of claim 6 further comprising monitoring the fluid pressure in the hemofiltration means to determine pressures and pressure differential and generating signals correlated thereto.
Claim 11
Dependent Claim
38 words
The method of claim 6 wherein said pumping of infusate to the hemofiltration means and said pumping of drained fluid from the hemofiltration means are controlled to occur only during said pumping of blood through the hemofiltration means.
Claim 12
Dependent Claim
197 words
Hemofiltration method for removal of fluid from the blood of a patient, comprising: pumping blood from a patient through hemofiltraiton means and back to the patient; maintaining a supply of infusate in a first reservoir; pumping the infusate to the patient; monitoring the weight of the infusate and generating signals correlated thereto; pumping drained fluid from the hemofiltration means into a second reservoir; monitoring the weight of the drained fluid and generating signals correlated thereto; controlling the pumping of the blood, infusate and drained fluid by means of a computer programmed to operate the pumps for infusate and drained fluid only when the blood is being pumped, said computer being responsive to the infusate and drained fluid weight signals; said blood pumping operation being responsive to signals generated by said computer to vary the flow rate of the blood through the hemofiltration means; and determining, at regular intervals, the weight of infusate in the first reservoir and the weight of drained fluid in the second reservoir, comparing those weights to corresponding predetermined ideal weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood.
Claim 13
Dependent Claim
197 words
Hemofiltration method for removal of fluid from the blood of a patient, comprising: pumping blood from a patient through hemofiltraiton means and back to the patient; maintaining a supply of infusate in a first reservoir; pumping the infusate to the patient; monitoring the weight of the infusate and generating signals correlated thereto; pumping drained fluid from the hemofiltration means into a second reservoir; monitoring the weight of the drained fluid and generating signals correlated thereto; controlling the pumping of the blood, infusate and drained fluid by means of a computer programmed to operate the pumps for infusate and drained fluid only when the blood is being pumped, said computer being responsive to the infusate and drained fluid weight signals; said blood pumping operation being responsive to signals generated by said computer to vary the flow rate of the blood through the hemofiltration means; and determining, at regular intervals, the weight of infusate in the first reservoir and the weight of drained fluid in the second reservoir, comparing those weights to corresponding predetermined ideal weights and adjusting the rates of pumping the infusate and drained fluid so as to remove a preselected amount of fluid from the blood.
Claim 14
Dependent Claim
26 words
The method of claim 9 further comprising monitoring the fluid pressure in the hemofiltration means to determine pressures and pressure differential and generating signals correlated thereto.
Claim 15
Dependent Claim
37 words
The method of claim 9 wherein said pumping of infusate to the patient and said pumping of drained fluid from the hemofiltration means are controlled to occur only during said pumping of blood through the hemofiltration means.
References Cited (Backward Citations)
US4204957A
Cited
US4178240A
Cited
US4324663A
Cited
US4132644A
Cited
FR2397197A1
Cited
US4372846A
Cited
US4582598A
Cited
US4980054A
Cited
US4728433A
Cited
US4606826A
Cited
US4684460A
Cited
US4769132A
Cited
US4889635A
Cited
US4767399A
Cited
US4923598A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-17 | 1996-11-16 | 1997-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-17 | 2000-11-16 | 2001-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-17 | 2004-11-16 | 2005-05-18 | $7700.00 | Window Closed / Lapsed |