Apparatus for controlling ultrafiltration and method for the same

Claim 1

An apparatus for controlling ultrafiltration in a dialysis system for artificial kidney including a dialyzer, a blood supply line for supplying a blood to the dialyzer, a blood discharge line for discharging the treated blood from the dialyzer, a liquid supply line for supplying a dialyzing liquid to the dialyzer, and a liquid discharge line for discharging the used dialyzing liquid from the dialyzer, and a negative pressure pump provided on the liquid discharge line, which comprises: a bypass line for connecting said liquid supply line directly to said liquid discharge line and having a first control valve means; a second control valve means disposed on said liquid discharge line in the upper stream of the junction of the liquid discharge line with the bypass line; an ultafiltration measuring line connected at its both ends to said liquid discharge line interposing said second valve means therebetween and equipped with a measuring chamber; an air lead-in line having a third control valve means and a check valve means, with one end of said air lead-in line being connected to said ultrafiltration measuring line and the other end exposed to the atmosphere; and a liquid withdrawal control means comprising a pressure control circuit and a microcomputer, said control means electrically connecting to pressure gauges disposed at the blood inlet side and outlet side, respectively, of the dialyzer and pressure gauges disposed at the dialyzing liquid inlet side and outlet side, respectively, of the dialyzer, and level sensors adapted to detect liquid level in said measuring chamber and said negative pressure pump.

Claim 2

An apparatus for controlling ultrafiltration in a dialysis system for artificial kidney including a dialyzer, a blood supply line for supplying a blood to the dialyzer, a blood discharge line for discharging the treated blood from the dialyzer, a liquid supply line for supplying a dialyzing liquid to the dialyzer, and a liquid discharge line for discharging the used dialyzing liquid from the dialyzer, and a negative pressure pump provided on the liquid discharge line, which comprises: a bypass line for connecting said liquid supply line directly to said liquid discharge line and having a first control valve means; a second control valve means disposed on said liquid discharge line in the upper stream of the junction of the liquid discharge line with the bypass line; an ultafiltration measuring line connected at its both ends to said liquid discharge line interposing said second valve means therebetween and equipped with a measuring chamber; an air lead-in line having a third control valve means and a check valve means, with one end of said air lead-in line being connected to said ultrafiltration measuring line and the other end exposed to the atmosphere; and a liquid withdrawal control means comprising a pressure control circuit and a microcomputer, said control means electrically connecting to pressure gauges disposed at the blood inlet side and outlet side, respectively, of the dialyzer and pressure gauges disposed at the dialyzing liquid inlet side and outlet side, respectively, of the dialyzer, and level sensors adapted to detect liquid level in said measuring chamber and said negative pressure pump.

Claim 6

A method for controlling ultrafiltration in a dialysis system for artificial kidney which comprises: in association with an apparatus for controlling ultrafiltration in a dialysis system for artificial kidney including a dialyzer, a blood supply line for supplying a blood to the dialyzer, a blood discharge line for discharging the treated blood from the dialyzer, a liquid supply line for supplying a dialyzing liquid to the dialyzer, and a liquid discharge line for discharging the used dialyzing liquid from the dialyzer, and a negative pressure pump provided on the liquid discharge line, which comprises: a bypass line for connecting said liquid supply line directly to said liquid discharge line and having a first control valve means; a second control valve means disposed on said liquid discharge line in the upper stream of the junction of the liquid discharge line with the bypass line; an ultafiltration measuring line connected at its both ends to said liquid discharge line interposing said second valve means therebetween and equipped with a measuring chamber; an air lead-in line having a third control valve means and a check valve means, with one end of said air lead-in line being connected to said ultrafiltration measuring line and the other end exposed to the atmosphere; and a liquid withdrawal control means comprising a pressure control circuit and a microcomputer, said control means electrically connecting to pressure gauges disposed at the blood inlet side and outlet side, respectively, of the dialyzer and pressure gauges disposed at the dialyzing liquid inlet side and outlet side, respectively, of the dialyzer, and level sensors adapted to detect liquid level in said measuring chamber and said negative pressure pump; computing UFR on the basis of the amount of ultrafiltrate determined in said ultrafiltration measuring line; computing TMP using one of the following TMP computation formulae: (a) in the case that, on the dialyzing liquid side, the pressure at the dialyzing liquid inlet side of the dialyzer (P Din ) and the pressure at the dialyzing liquid outlet side of the dialyzer (P Dout ) are to be measured, ##EQU4## wherein P A is the arterial side pressure immediately before the blood inlet of the dialyzer, P V is the venous side pressure immediately after the blood outlet of the dialyzer, and ΔP 1 is a zeroing correction factor for TMP as determined prior to the initiation of dialysis treatment, irrespective of whether a dialyzing liquid is flowing or not through the dialyzer, (b) in the case that either P Din or P Dout only is to be measured on the dialyzing liquid side, (b-1) in the case that a dialyzing liquid is flowing through the dialyzer, ##EQU5## wherein P D is the measured P Din or P Dout and ΔP 2 is a correction factor for TMP, or (b-2) in the case that a dialyzing liquid is not flowing through the dialyzer, ##EQU6## wherein ΔP 2 ' is a correction factor for TMP, computing UFRP from said TMP value and said UFR value, computing a TMP value corresponding to a predetermined UFR value using said UFRP value, and controlling said negative pressure pump to provide a dialyzing liquid pressure corresponding to the last-mentioned TMP value.

Claim 7

A method for controlling ultrafiltration in a dialysis system for artificial kidney which comprises: in association with an apparatus for controlling ultrafiltration in a dialysis system for artificial kidney including a dialyzer, a blood supply line for supplying a blood to the dialyzer, a blood discharge line for discharging the treated blood from the dialyzer, a liquid supply line for supplying a dialyzing liquid to the dialyzer, and a liquid discharge line for discharging the used dialyzing liquid from the dialyzer, and a negative pressure pump provided on the liquid discharge line, which comprises: a bypass line for connecting said liquid supply line directly to said liquid discharge line and having a first control valve means; a second control valve means disposed on said liquid discharge line in the upper stream of the junction of the liquid discharge line with the bypass line; an ultafiltration measuring line connected at its both ends to said liquid discharge line interposing said second valve means therebetween and equipped with a measuring chamber; an air lead-in line having a third control valve means and a check valve means, with one end of said air lead-in line being connected to said ultrafiltration measuring line and the other end exposed to the atmosphere; and a liquid withdrawal control means comprising a pressure control circuit and a microcomputer, said control means electrically connecting to pressure gauges disposed at the blood inlet side and outlet side, respectively, of the dialyzer and pressure gauges disposed at the dialyzing liquid inlet side and outlet side, respectively, of the dialyzer, and level sensors adapted to detect liquid level in said measuring chamber and said negative pressure pump; computing UFR on the basis of the amount of ultrafiltrate determined in said ultrafiltration measuring line; computing TMP using one of the following TMP computation formulae: (a) in the case that, on the dialyzing liquid side, the pressure at the dialyzing liquid inlet side of the dialyzer (P Din ) and the pressure at the dialyzing liquid outlet side of the dialyzer (P Dout ) are to be measured, ##EQU4## wherein P A is the arterial side pressure immediately before the blood inlet of the dialyzer, P V is the venous side pressure immediately after the blood outlet of the dialyzer, and ΔP 1 is a zeroing correction factor for TMP as determined prior to the initiation of dialysis treatment, irrespective of whether a dialyzing liquid is flowing or not through the dialyzer, (b) in the case that either P Din or P Dout only is to be measured on the dialyzing liquid side, (b-1) in the case that a dialyzing liquid is flowing through the dialyzer, ##EQU5## wherein P D is the measured P Din or P Dout and ΔP 2 is a correction factor for TMP, or (b-2) in the case that a dialyzing liquid is not flowing through the dialyzer, ##EQU6## wherein ΔP 2 ' is a correction factor for TMP, computing UFRP from said TMP value and said UFR value, computing a TMP value corresponding to a predetermined UFR value using said UFRP value, and controlling said negative pressure pump to provide a dialyzing liquid pressure corresponding to the last-mentioned TMP value.