EP0224987A2
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EP
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Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
Assignee: Seagull Merger Corp
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Filing: 1986-08-05
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Granted: —
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Expires: 2006-08-05
Abstract
Abstract Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.
Inventors
- 👤 Endre A. Balazs
- 👤 Nancy E. Larsen
- 👤 Adolf Leshchiner
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 14:43
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K9/00; A61K9/0012; A61K9/0048; A61K9/70; A61K9/7007
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
56 words
A drug delivery system comprising a polymeric component which is a soluble or insoluble hyaluronan or hylan, and a selected amount of at least one substance having biological or pharmacological activity and which is controllably releasable from said system so as to effect delivery of a. therapeutically effective amount of said substance to a desired site.
Claim 2
Dependent Claim
56 words
A drug delivery system comprising a polymeric component which is a soluble or insoluble hyaluronan or hylan, and a selected amount of at least one substance having biological or pharmacological activity and which is controllably releasable from said system so as to effect delivery of a. therapeutically effective amount of said substance to a desired site.
Claim 3
Dependent Claim
26 words
A drug delivery system in accordance with Claim 1 wherein the polymeric component is a soluble hyaluronan or hylan.and comprises an aqueous hyaluronan or hylan solution.
Claim 4
Dependent Claim
21 words
A drug delivery system in accordance with Claim 2 wherein the said substance is dissolved or dispersed in the aqueous solution.
Claim 5
Dependent Claim
19 words
A drug delivery system in accordance with Claim 2 or Claim 3 wherein the solution is a viscoelastic putty.
Claim 6
Dependent Claim
25 words
A drug delivery system in accordance with any one of Claims 2-4 wherein the hyaluronan or hylan concentration is about 0.05 to 4% by weight.
Claim 7
Dependent Claim
27 words
A drug delivery system in accordance with any one of Claims 2-5 in the form of an injectable product or a topical product such as eye drops.
Claim 8
Dependent Claim
47 words
A drug delivery system in the form of a topical product in accordance with Claim 6 wherein the hyaluronan or hylan has a molecular weight of at least about 1 x 10 and the concentration of hyaluronan or hylan is from about 0.05 to 2% by weight.
Claim 9
Dependent Claim
21 words
A drug delivery system in accordance with any one of Claims 2-7 wherein the said substance is serotonin, or salicylic acid.
Claim 10
Dependent Claim
16 words
A drug delivery system in accordance with Claim 1 wherein the hyaluronan is an insoluble hyaluronan.
Claim 11
Dependent Claim
43 words
A drug delivery system in accordance with Claim 9 wherein the insoluble hyaluronan is a cross-linked gel of hyaluronan, or a cross-linked gel of hyaluronan and at least one other hydrophilic polymer, preferably containing 5% to 95% by weight of said insoluble hyaluronan.
Claim 12
Dependent Claim
75 words
A drug delivery system in accordance with Claim 10 wherein the other hydrophilic is a polymer having a functional group capable of reacting with divinyl sulfone, preferably a natural or synthetic polysaccharide selected from hydroxyethyl cellulose, carboxymethyl cellulose, xanthan gum, glycosaminoglycans; a protein or glycoprotein selected from collagen, elastin, albumin, a globulin, keratin sulfate, a sulfated aminoglycosaminoglycan and a synthetic water soluble polymer selected from the polyvinyl alcohol and its co-polymers and co-polymers of poly-(hydroxyethyl)-methacrylate.
Claim 13
Dependent Claim
30 words
A drug delivery system in accordance with Claim 9 wherein the insoluble hyaluronan is in the form of a molecular cage and the substance is dispersed within said molecular cage.
Claim 14
Dependent Claim
29 words
A drug delivery system in accordance with Claim 9 wherein the said substance is covalently bonded to the macromolecules of hyaluronan or said at least one other hydrophilic polymer.
Claim 15
Dependent Claim
28 words
A drug delivery system in accordance with Claim 13 in combination with a support or substrate therefor, preferably a polymeric porous sponge, a gauze or a polymeric film.
Claim 16
Dependent Claim
39 words
A drug delivery system in accordance with Claim 14 and comprising (a) a membrane formed of a gel of hyaluronan containing gentamicin or mydriacyl, or (b) a membrane formed of a gel of hyaluronan and chondroitin sulfate containing gentamicin.
Claim 17
Dependent Claim
21 words
A drug delivery system in accordance with Claim 13 and comprising a gel of cross-linked hyaluronan and gentamicin covalently attached thereto.
Claim 18
Dependent Claim
34 words
A drug delivery system in accordance with Claim 14 and comprising a porous polymeric sponge for example a polyurethane sponge, said sponge having a hyaluronan gel immobilized therein together with said substance, preferably serotonin.
Claim 19
Dependent Claim
27 words
A drug delivery system in accordance with Claim 14 and comprising a cotton gauze, said gauze having a hyaluronan.gel immobilized therein together with said substance, preferably gentamicin.
Claim 20
Dependent Claim
46 words
A method of obtaining a product in accordance with Claim 2, comprising either (a) dissolving or dispersing the said substance in a water or saline solution of hyaluronan or hylan, or (b) mixing a solution or dispersion of the substance with a hyaluronan or hylan solution.
Claim 21
Dependent Claim
34 words
A method of obtaining a product in accordance with Claim 4 comprising adding the said substance to a solution of hyaluronan or nylan and adjusting the pH of the resulting mixture to about 2.5.
Claim 22
Dependent Claim
109 words
A method of obtaining a product in accordance with Claim 10, comprising (a) placing the gel into a solution of the said substance and allowing the substance to diffuse into the gel whereby a product having the substance uniformly dispersed therethrough is obtained; (b) dehydrating the gel and placing the dehydrated gel into a solution of the substance to cause reswelling of the dehydrated gel, said substance being diffused into the gel while the reswelling occurs; or (c) placing a concentrated gel in a solution of said substance and allowing the gel to swell in said solution whereby the substance is diffused into the gel while it is swelling.
Claim 23
Dependent Claim
29 words
A method in accordance with Claim 21 wherein said dehydrating is effected by treating the gel with a water miscible solvent, preferably ethanol, isopropanol or acetone, or by drying.
Claim 24
Dependent Claim
74 words
A method of obtaining a product in accordance with Claim 13, which comprises subjecting hyaluronan or a mixture of hyaluronan and the other hydrophilic polymer tb a cross-linking reaction in the presence of said substance, provided that said substance has a chemical group such as hydroxyl, amino or sulfhydryl reactive toward the cross-linking agent, to thereby cause the formation of covalent bonds between said chemical group and the hyaluronan or the other hydrophilic polymer.
Claim 25
Dependent Claim
12 words
A method in accordance with Claim 23 wherein said substance is gentamicin.
References Cited (Backward Citations)
No citation records indexed.
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