US5198220A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release compositions for treating periodontal disease
Assignee: Procter and Gamble Co
•
Filing: 1990-08-24
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Granted: 1993-03-30
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Expires: 2010-08-24
Abstract
Abstract This invention relates to compositions/devices and methods for treating diseases of the oral cavity in humans and lower animals using polylactide/glycolide compositions/devices for releasing drugs in the oral cavity.
Inventors
- 👤 Nalinkant C. Damani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:24
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K47/00; A61K47/30; A61K9/20; A61P; A61P1/00; A61P1/02
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
142 words
A liquid, semi-solid or solid composition suitable for insertion into or around the periodontal pocket of a person or lower animal suffering from diseases of the oral cavity comprising a copolymer of lactide and glycolide in a concentration from about 10% to about 90% wherein the molar percentage centage of lactide units is from about 15% to about 85%, a active drug selected from the group consisting of antiinflammatory agents, antimicrobials, antibiotics, peroxides, anesthetic agents and vitamins in a concentration from about 1% to about 90% and propylene carbonate in a concentration from about 0.1% to about 90%, the ratio of the components being such that the drug active is released at a rate to provide steady state number average concentrations of from about 10 micrograms to about 2000 micrograms per milliliter of the gingival crevicular fluid of a treated periodontal pocket.
Claim 2
Dependent Claim
142 words
A liquid, semi-solid or solid composition suitable for insertion into or around the periodontal pocket of a person or lower animal suffering from diseases of the oral cavity comprising a copolymer of lactide and glycolide in a concentration from about 10% to about 90% wherein the molar percentage centage of lactide units is from about 15% to about 85%, a active drug selected from the group consisting of antiinflammatory agents, antimicrobials, antibiotics, peroxides, anesthetic agents and vitamins in a concentration from about 1% to about 90% and propylene carbonate in a concentration from about 0.1% to about 90%, the ratio of the components being such that the drug active is released at a rate to provide steady state number average concentrations of from about 10 micrograms to about 2000 micrograms per milliliter of the gingival crevicular fluid of a treated periodontal pocket.
Claim 3
Dependent Claim
22 words
A composition according to claim 1 wherein the number average molecular weight of the copolymer is from about 1000 to about 120,000.
Claim 4
Dependent Claim
33 words
A composition according to claim 2 wherein the concentration of the active drug drug active is from about 10% to about 50% and the active is selected from the tetracycline group of antibiotics.
Claim 5
Dependent Claim
53 words
A composition according to claim 3 wherein the composition is formed into a semi solid or solid shape having a width of from about 0.1 mm to about 5 mm, a thickness of from about 0.01 mm to about 2 mm and a length of from about 1 mm to about 15 mm.
Claim 6
Dependent Claim
41 words
A method of treating diseases of the oral cavity in a person or lower animal suffering from such disease by placing into the periodontal pocket or around said pocket of said person or lower animal a composition according to claim 1.
Claim 7
Dependent Claim
19 words
A method according to claim 5 wherein the active drug active is selected from the tetracycline group of antibiotics.
Claim 8
Dependent Claim
53 words
A method according to claim 6 wherein the composition is formed into a shape having a semi solid or solid width of from about 0.1 mm to about 5 mm, a thickness of from about 0.01 mm to about 2 mm and a length of from about 1 mm to about 15 mm.
References Cited (Backward Citations)
US4017615A
Cited
US3736646A
Cited
US3867190A
Cited
US4328204A
Cited
US4454110A
Cited
US4443430A
Cited
US4685883A
Cited
EP0140766A2
Cited
US4652441A
Cited
US4711782A
Cited
US4650665A
Cited
US4568536A
Cited
US4670252A
Cited
US4624256A
Cited
EP0241178A1
Cited
US4713243A
Cited
JPS6379817A
Cited
US4810775A
Cited
JPS63287719A
Cited
EP0297535A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-03-29 | 1996-09-28 | 1997-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-29 | 2000-09-28 | 2001-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-29 | 2004-09-28 | 2005-03-30 | $7700.00 | Window Closed / Lapsed |