US5171271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptides with fibronectin activity
Assignee: University of Minnesota System
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Filing: 1991-02-28
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Granted: 1992-12-15
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Expires: 2011-02-28
Abstract
Abstract A medical device is provided which is coated with a polypeptide which can bind heparin and promote cellular adhesion and neurite outgrowth is provided of the formula: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gly-pro-pro-arg-ala-arg-ile, or mixtures thereof.
Inventors
- 👤 Leo T. Furcht
- 👤 James B. McCarthy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:33
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/28; C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/78; C12; C12N; C12N5/00; C12N5/0068; C12N2533/00; C12N2533/50; C12N2533/52
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
32 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a polypeptide of the formula selected from the group consisting of: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, and mixtures thereof.
Claim 2
Dependent Claim
32 words
A prosthetic device designed for placement in vivo, comprising a surface coated with a polypeptide of the formula selected from the group consisting of: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, and mixtures thereof.
Claim 3
Dependent Claim
16 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a vascular graft.
Claim 4
Dependent Claim
17 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of an intraocular contact lens.
Claim 5
Dependent Claim
16 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a heart valve.
Claim 6
Dependent Claim
17 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a hip replacement implant.
Claim 7
Dependent Claim
16 words
The prosthetic device of claim 1, wherein said surface constitutes a portion of a percutaneous device.
Claim 8
Dependent Claim
15 words
A prosthetic device of claim 1, wherein said surface is made of a synthetic resin.
Claim 9
Dependent Claim
26 words
A prosthetic device in accordance with claim 7 wherein said synthetic resin is selected from the group consisting of nitrocellulose, polyurethane, expanded polytetrafluoroethylene, polyester and polyolefin.
Claim 10
Dependent Claim
15 words
A prosthetic device of claim 1 wherein said surface is made of a naturally-occurring tissue.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-15 | 1996-06-15 | 1996-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-15 | 2000-06-15 | 2000-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-15 | 2004-06-15 | 2004-12-15 | $7700.00 | Window Closed / Lapsed |