US4578079A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tetrapeptide
Assignee: Sanford Burnham Prebys Medical Discovery Institute
•
Filing: 1983-11-22
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Granted: 1986-03-25
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Expires: 2003-11-22
Abstract
Abstract The peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, or other amino acid, having the same cell-attachment activity as fibronectin and the peptide X-Arg-Gly-Asp-Ser-Y, wherein X and Y, having said activity are disclosed.
Inventors
- 👤 Erkki Ruoslahti
- 👤 Michael Pierschbacher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:56
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
62 words
A composition of matter which promotes the attachment of cells to substrate when immobilized on the substrate and consisting essentially of the peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, characterized in that it has cell-attachment-promoting activity.
Claim 2
Dependent Claim
62 words
A composition of matter which promotes the attachment of cells to substrate when immobilized on the substrate and consisting essentially of the peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys, characterized in that it has cell-attachment-promoting activity.
Claim 3
Dependent Claim
14 words
The polypeptide fragment of claim 1 attached to the surface of a prosthetic device.
Claim 4
Dependent Claim
15 words
the polypeptide fragment of claim 1 attached to the surface of a synthetic resin fiber.
Claim 5
Dependent Claim
14 words
The polypeptide fragment of claim 1 attached to the surface of a percutaneous device.
Claim 6
Dependent Claim
24 words
The polypeptide fragment of claim 1 attached to the surface of a solid substrate to ensure that cells will attach to said substrate surface.
Claim 7
Dependent Claim
16 words
The polypeptide fragment of claim 5 wherein said substrate is glass, synthetic resin or long-chain polysaccharide.
Claim 8
Dependent Claim
13 words
The polypeptide fragment of claim 6 wherein the substrate is nitrocellulose or polyester.
Claim 9
Dependent Claim
11 words
The polypeptide fragment of claim 1 wherein the substrate is agarose.
Claim 10
Dependent Claim
9 words
The polypeptide fragment of claim 1 coupled to collagen.
Claim 11
Dependent Claim
15 words
The polypeptide fragment of claim 1 coupled to and forming part of a vascular graft.
Claim 12
Dependent Claim
17 words
The polypeptide fragment of claim 1 in the form of a lotion, salve, gel, colloid or powder.
Claim 13
Dependent Claim
38 words
A synthetic peptide containing the sequence X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys.
Claim 14
Dependent Claim
38 words
A synthetic peptide containing the sequence X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys.
Claim 15
Dependent Claim
14 words
The polypeptide fragment of claim 12 attached to the surface of a prosthetic device.
Claim 16
Dependent Claim
15 words
The polypeptide fragment of claim 12 attached to the surface of a synthetic resin fiber.
Claim 17
Dependent Claim
14 words
The polypeptide fragment of claim 12 attached to the surface of a percutaneous device.
Claim 18
Dependent Claim
24 words
The polypeptide fragment of claim 12 attached to the surface of a solid substrate to ensure that cells will attach to said substrate surface.
Claim 19
Dependent Claim
16 words
The polypeptide fragment of claim 16 wherein said substrate is glass, synthetic resin or long-chain polysaccharide.
Claim 20
Dependent Claim
13 words
The polypeptide fragment of claim 17 wherein the substrate is nitrocellulose or polyester.
Claim 21
Dependent Claim
11 words
The polypeptide fragment of claim 12 wherein the substrate is agarose.
Claim 22
Dependent Claim
9 words
The polypeptide fragment of claim 12 coupled to collagen.
Claim 23
Dependent Claim
15 words
The polypeptide fragment of claim 12 coupled to and forming part of a vascular graft.
Claim 24
Dependent Claim
17 words
The polypeptide fragment of claim 12 in the form of a lotion, salve, gel, colloid or powder.
Claim 25
Dependent Claim
60 words
A polypeptide having a biologically active sequence exhibiting cell attachment activity having less than about 30 amino acids which exhibits cell attachment activity resulting substantially from the peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys.
Claim 26
Dependent Claim
60 words
A polypeptide having a biologically active sequence exhibiting cell attachment activity having less than about 30 amino acids which exhibits cell attachment activity resulting substantially from the peptide X-Arg-Gly-Asp-R-Y wherein X is H or at least one amino acid and Y is OH or at least one amino acid, and R is an amino acid selected from Thr or Cys.
Claim 27
Dependent Claim
13 words
The polypeptide fragment of claim 23 attached to the surface of prosthetic device.
Claim 28
Dependent Claim
15 words
The polypeptide fragment of claim 23 attached to the surface of a synthetic resin fiber.
Claim 29
Dependent Claim
14 words
The polypeptide fragment of claim 23 attached to the surface of a percutaneous device.
Claim 30
Dependent Claim
24 words
The polypeptide fragment of claim 23 attached to the surface of a solid substrate to ensure that cells will attach to said substrate surface.
Claim 31
Dependent Claim
16 words
The polypeptide fragment of claim 23 wherein said substrate is glass, synthetic resin or long-chain polysaccharide.
Claim 32
Dependent Claim
13 words
The polypeptide fragment of claim 23 wherein the substrate is nitrocellulose or polyester.
Claim 33
Dependent Claim
11 words
The polypeptide fragment of claim 23 wherein the substrate is agarose.
Claim 34
Dependent Claim
9 words
The polypeptide fragment of claim 23 coupled to collagen.
Claim 35
Dependent Claim
15 words
The polypeptide fragment of claim 23 coupled to and forming part of a vascular graft.
Claim 36
Dependent Claim
17 words
The polypeptide fragment of claim 23 in the form of a lotion, salve, gel, colloid or powder.
Claim 37
Dependent Claim
26 words
A composition of matter which promotes the attachment of cells to substrate when immobilized on the substrate and consisting essentially of the peptide-Arg-Gly-Asp- having cell-attachment-promoting activity.
Claim 38
Dependent Claim
26 words
A composition of matter which promotes the attachment of cells to substrate when immobilized on the substrate and consisting essentially of the peptide-Arg-Gly-Asp- having cell-attachment-promoting activity.
Claim 39
Dependent Claim
14 words
The polypeptide fragment of claim 34 attached to the surface of a prosthetic device.
Claim 40
Dependent Claim
15 words
The polypeptide fragment of claim 34 attached to the surface of a synthetic resin fiber.
Claim 41
Dependent Claim
14 words
The polypeptide fragment of claim 34 attached to the surface of a percutaneous device.
Claim 42
Dependent Claim
24 words
The polypeptide fragment of claim 34 attached to the surface of a solid substrate to ensure that cells will attach to said substrate surface.
Claim 43
Dependent Claim
16 words
The polypeptide fragment of claim 38 wherein said substrate is glass, synthetic resin or long-chain polysaccharide.
Claim 44
Dependent Claim
13 words
The polypeptide fragment of claim 39 wherein the substrate is nitrocellulose or polyester.
Claim 45
Dependent Claim
11 words
The polypeptide fragment of claim 34 wherein the substrate is agarose.
Claim 46
Dependent Claim
9 words
The polypeptide fragment of claim 34 coupled to collagen.
Claim 47
Dependent Claim
15 words
The polypeptide fragment of claim 34 coupled to and forming part of a vascular graft.
Claim 48
Dependent Claim
17 words
The polypeptide fragment of claim 34 in the form of a lotion, salve, gel, colloid or powder.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-24 | 1989-09-23 | 1990-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-24 | 1993-09-23 | 1994-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-24 | 1997-09-23 | 1998-03-25 | $7700.00 | Window Closed / Lapsed |