US5019646A
Expired / Lapsed
US
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Polypeptides with fibronectin activity
Assignee: University of Minnesota Twin Cities
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Filing: 1988-07-27
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Granted: 1991-05-28
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Expires: 2008-07-27
Abstract
Abstract A polypeptide which can bind heparin and promote cellular adhesion and neurite outgrowth is provided of the formula: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gly-pro-pro-arg-ala-arg-ile, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with the polypeptide composition are also provided.
Inventors
- 👤 Leo T. Furcht
- 👤 James B. McCarthy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/28; A61L27/36; A61L27/38; A61P; A61P43/00; C07K14/46; C07K14/47; C12; C12N; C12N5/00; C12N5/0068; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2/24; C12N2533/00; C12N2533/50; C12N2533/52
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
19 words
A polypeptide of the formula selected from the group consisting of: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, and mixtures thereof.
Claim 2
Dependent Claim
19 words
A polypeptide of the formula selected from the group consisting of: lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, and mixtures thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-27 | 1994-11-26 | 1995-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-27 | 1998-11-26 | 1999-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-27 | 2002-11-26 | 2003-05-28 | $7700.00 | Window Closed / Lapsed |