US4981691A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxygenated fluorocarbon nutrient solution
Assignee: Thomas Jefferson University
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Filing: 1989-04-05
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Granted: 1991-01-01
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Expires: 2009-04-05
Abstract
Abstract The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.
Inventors
- 👤 Jewell L. Osterholm
- 👤 Glenn D. Frazer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K9/0029; A61M; A61M3/00; A61M3/02; A61M25/00; A61M25/01; A61M25/02; A61M2025/028; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
107 words
A method making an oxygenatable synthetic nutrient cerebrospinal treatment fluid for treating hypoxic-ischemic central nervous system tissue, comprising the steps of: (a) emulsifying an oxygenatable fluorocarbon material comprising bis-perflurobutyl ethylene with a synthetic electrolyte-containing cerebrospinal aqueous fluid to produce a physiologically acceptable emulsion; (b) normalizing the electrolytes and adjusting the pH of said emulsion to produce an osmotically equilibrated and acid-base balanced emulsion; and (c) adding nutrients to said emulsion to produce said oxygenatable synthetic nutrient treatment fluid, said nutrients comprising at least one amino acid selected from the group consisting of glycine, lysine, tryptophan, alanine, serine, threonine, arginine, leucine, valine, phenylalanine, tyrosine, histidine, methionine and isoleucine.
Claim 2
Independent Claim
107 words
A method making an oxygenatable synthetic nutrient cerebrospinal treatment fluid for treating hypoxic-ischemic central nervous system tissue, comprising the steps of: (a) emulsifying an oxygenatable fluorocarbon material comprising bis-perflurobutyl ethylene with a synthetic electrolyte-containing cerebrospinal aqueous fluid to produce a physiologically acceptable emulsion; (b) normalizing the electrolytes and adjusting the pH of said emulsion to produce an osmotically equilibrated and acid-base balanced emulsion; and (c) adding nutrients to said emulsion to produce said oxygenatable synthetic nutrient treatment fluid, said nutrients comprising at least one amino acid selected from the group consisting of glycine, lysine, tryptophan, alanine, serine, threonine, arginine, leucine, valine, phenylalanine, tyrosine, histidine, methionine and isoleucine.
Claim 3
Dependent Claim
13 words
The method of claim 1 further comprising the step of oxygenating said fluid.
Claim 4
Dependent Claim
32 words
The method of claim 1 wherein said electrolytes are normalized to produce a hypertonic osmolarity, whereby said treatment fluid, after oxygenation, is further useful for counteracting edema of said hypoxic-ischemic neurologic tissues.
Claim 5
Dependent Claim
46 words
An oxygenatable synthetic nutrient cerebrospinal treatment fluid, comprising: bis-perflurobutyl ethylene emulsified in a synthetic electrolyte-containing cerebrospinal aqueous fluid, said fluid comprising electrolytes, lecithin, amino acids selected from the group consisting of glycine, lysine, tryptophan, alanine, serine, threonine, arginine, leucine, valine, phenylalanine, tyrosine, histidine, methionine and isoleucine.
Claim 6
Dependent Claim
46 words
An oxygenatable synthetic nutrient cerebrospinal treatment fluid, comprising: bis-perflurobutyl ethylene emulsified in a synthetic electrolyte-containing cerebrospinal aqueous fluid, said fluid comprising electrolytes, lecithin, amino acids selected from the group consisting of glycine, lysine, tryptophan, alanine, serine, threonine, arginine, leucine, valine, phenylalanine, tyrosine, histidine, methionine and isoleucine.
Claim 7
Dependent Claim
15 words
The treatment fluid of claim 4 wherein said electrolyte-containing cerebrospinal aqueous fluid further comprises glucose.
Claim 8
Dependent Claim
15 words
The treatment fluid of claim 4 wherein said electrolyte-containing cerebrospinal aqueous fluid further comprises albumin.
Claim 9
Dependent Claim
17 words
The treatment fluid of claim 4 wherein said electrolyte-containing cerebrospinal aqueous fluid further comprises alpha ketoglutaric acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-31 | 1994-07-02 | 1995-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-31 | 1998-07-02 | 1999-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-31 | 2002-07-02 | 2003-01-01 | $7700.00 | Window Closed / Lapsed |