Patent US5461124A successfully refreshed from Google Patents.
Patent US5084001A successfully refreshed from Google Patents.
US5084001A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for effecting radioactive therapy in an animal body
Assignee: Nucletron Operations BV
•
Filing: 1990-08-09
•
Granted: 1992-01-28
•
Expires: 2010-08-09
Abstract
Abstract A method and apparatus for effecting radiation therapy by placing at least one guide tube through an orifice in an animal body and disposing the end portion of the guide tube near the site of intended therapy. The other end of the guide tube is connected to a channel in a shielding block. A high dose radiation source assembly is moved from the channel to the end portion and positioned a plurality of times at each of a series of preselected positions lying in the end portion to effect a plurality of pulsed radiations. The effects of low dose radiation can be duplicated by the high dose radiation source, the radiation field can be patterned, and when the repeated pulsed radiations are within repair times of healthy cells, cancer cells are destroyed and healthy cells survive.
Inventors
- 👤 Eric van't Hooft
- 👤 Libbe van Zwol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:22
CPC Classifications
F; F16; F16C; F16C1/00; F16C1/10; F16C1/12; F16C1/18; A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1007; A61N2005/1008
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
204 words
A method for effecting radiation therapy of a site of intended therapy in an animal body comprising: (1) placing at least one guide tube through at least one orifice in the body such that an end portion of the guide tube is disposed near the site of intended therapy; (2) connecting an other end of the guide tube to a channel of a radiation shielding block; (3) moving a radioactive source assembly, and controlling the movement thereof with a computer, such that the source assembly is moved from a standby position toward said end portion of the guide tube and positioning the source assembly a plurality of times at each of a series of preselected positions lying within the guide tube and allowing the source assembly to remain at each of the preselected positions for a plurality of time spaced apart variable residence times such that each position experiences a plurality of time spaced apart variable radiations by said source assembly; and (4) withdrawing the source assembly from said guide tube; and wherein said preselected positions and the plurality of residence times at each preselected position are in combination sufficient for the source assembly to produce therapeutic radiation of the site of intended therapy.
Claim 2
Independent Claim
204 words
A method for effecting radiation therapy of a site of intended therapy in an animal body comprising: (1) placing at least one guide tube through at least one orifice in the body such that an end portion of the guide tube is disposed near the site of intended therapy; (2) connecting an other end of the guide tube to a channel of a radiation shielding block; (3) moving a radioactive source assembly, and controlling the movement thereof with a computer, such that the source assembly is moved from a standby position toward said end portion of the guide tube and positioning the source assembly a plurality of times at each of a series of preselected positions lying within the guide tube and allowing the source assembly to remain at each of the preselected positions for a plurality of time spaced apart variable residence times such that each position experiences a plurality of time spaced apart variable radiations by said source assembly; and (4) withdrawing the source assembly from said guide tube; and wherein said preselected positions and the plurality of residence times at each preselected position are in combination sufficient for the source assembly to produce therapeutic radiation of the site of intended therapy.
Claim 3
Dependent Claim
57 words
The method of claim 1 wherein after the source assembly remains at one of said preselected positions for a predetermined residence time, the source assembly is moved from that radiated preselected position to another preselected position of the series of said preselected positions and allowed to remain at said another preselected position for a predetermined residence time.
Claim 4
Dependent Claim
64 words
The method of claim 1 wherein after the source assembly remains at one of said preselected positions for a predetermined residence time, the source assembly is withdrawn therefrom to a rest position, and the source assembly is again subsequently moved from the rest position to that same preselected position and allowed to remain at that same preselected position for a predetermined further residence time.
Claim 5
Dependent Claim
19 words
The method of claim 3 wherein the source assembly remains at the rest position for a predetermined rest time.
Claim 6
Dependent Claim
45 words
The method of claim 4 wherein the rest time is a time period between successive radiations of a selected site such that there is a difference in total biological affect of the radiation on normal cells and cancer cells in the effective field of radiation.
Claim 7
Dependent Claim
24 words
The method of claim 5 wherein the rest time is in the range of at least thirty minutes to no more than six hours.
Claim 8
Dependent Claim
70 words
The method of claim 1 wherein there are a plurality of guide tubes disposed near the site of intended therapy and the source assembly is moved toward the end portion of each guide tube and positioned a plurality of times at each of a series of preselected positions lying in each guide tube and allowed to remain at each of the preselected positions for a plurality of predetermined residence times.
Claim 9
Dependent Claim
27 words
The method of claim 7 wherein the source assembly is moved to each of the preselected positions in each of the guide tubes in a selected order.
Claim 10
Dependent Claim
46 words
The method of claim 8 wherein the selected order is such that the source assembly is moved to each of the preselected positions in one of said guide tubes and then the source assembly is moved to other preselected positions in another of said guide tubes.
Claim 11
Dependent Claim
66 words
The method of claim 8 wherein the selected order is such that the source assembly is first moved to less than each of the preselected positions in a first of said guide tubes and then the source assembly is moved to a preselected position in another of said guide tubes and then the source assembly is moved to a preselected position in the first guide tube.
Claim 12
Dependent Claim
67 words
The method of claim 7 wherein after the source assembly remains at one of said preselected positions for a said predetermined residence time, the source assembly is withdrawn therefrom to a rest position, and the source assembly is again subsequently moved from the rest position to that same said preselected position and allowed to remain at that same said preselected position for a predetermined further residence time.
Claim 13
Dependent Claim
19 words
The method of claim 11 wherein the source assembly remains in the rest position for a predetermined rest time.
Claim 14
Dependent Claim
45 words
The method of claim 12 wherein the rest time is a time period between successive radiations of a selected site such that there is a difference in total biological affect of the radiation on normal cells and cancer cells in the effective field of radiation.
Claim 15
Dependent Claim
24 words
The method of claim 13 wherein the rest time is in the range of at least thirty minute to no more than six hours.
Claim 16
Dependent Claim
13 words
The method of claim 1 wherein the animal body is a human body.
Claim 17
Dependent Claim
20 words
The method of claim 1 wherein the source assembly is moved by a transport thread driven by a stepping motor.
Claim 18
Dependent Claim
16 words
The method of claim 1 wherein the source assembly is a high dose rate source assembly.
Claim 19
Dependent Claim
20 words
The method of claim 1 wherein any one residence time is at least one second and up to 120 seconds.
Claim 20
Dependent Claim
16 words
The method of claim 18 wherein the total residence times are between 10 and 40 minutes.
Claim 21
Independent Claim
213 words
An apparatus for effecting radiation therapy of a site of intended therapy in an animal body comprising: (1) a radiation shielding block having a channel therein; (2) at least one guide tube having an end portion disposable through at least one orifice in the body and positionable such that the end portion is near the site of intended therapy and an other end is connected to said channel of the radiation shielding block; (3) a radioactive source assembly disposed at a standby position in said channel; (4) moving means for moving the source assembly from said channel toward said end portion; (5) computer control means for controlling the moving means, which control means performs functions: (a) causing the source assembly to be moved from the standby position toward the end portion of the guide tube and positioned a plurality of times at each of a series of preselected positions lying within the guide tube such that preselected positions are radiated; (b) allowing the source assembly to remain at each of the preselected positions for a plurality of time spaced apart variable residence times such that each position experiences a plurality of time spaced apart variable radiations by said source assembly; and (c) causing the source assembly to be withdrawn from said guide tube.
Claim 22
Independent Claim
213 words
An apparatus for effecting radiation therapy of a site of intended therapy in an animal body comprising: (1) a radiation shielding block having a channel therein; (2) at least one guide tube having an end portion disposable through at least one orifice in the body and positionable such that the end portion is near the site of intended therapy and an other end is connected to said channel of the radiation shielding block; (3) a radioactive source assembly disposed at a standby position in said channel; (4) moving means for moving the source assembly from said channel toward said end portion; (5) computer control means for controlling the moving means, which control means performs functions: (a) causing the source assembly to be moved from the standby position toward the end portion of the guide tube and positioned a plurality of times at each of a series of preselected positions lying within the guide tube such that preselected positions are radiated; (b) allowing the source assembly to remain at each of the preselected positions for a plurality of time spaced apart variable residence times such that each position experiences a plurality of time spaced apart variable radiations by said source assembly; and (c) causing the source assembly to be withdrawn from said guide tube.
Claim 23
Dependent Claim
50 words
The apparatus of claim 20 wherein the control means performs functions of causing the sources assembly to be moved from a radiated preselected position to an unradiated preselected position of the series of positions and allowing the source assembly to remain at each unradiated position for a predetermined residence time.
Claim 24
Dependent Claim
66 words
The apparatus of claim 20 wherein the control means performs functions of causing the source assembly to be withdrawn from a radiated position to a rest position, and subsequently causing the source assembly to be again moved from the rest position to that same said radiated position and allowing the source assembly to remain at that same said radiated position for a predetermined further residence time.
Claim 25
Dependent Claim
28 words
The apparatus of claim 22 wherein the control means performs the function of causing the source assembly to remain at said rest position for a predetermined rest time.
Claim 26
Dependent Claim
45 words
The apparatus of claim 23 wherein the rest time is a time period between successive radiations of a selected site such that there is a difference in total biological affect of the radiation on normal cells and cancer cells in the effective field of radiation.
Claim 27
Dependent Claim
24 words
The apparatus of claim 24 wherein the rest time is in the range of at least thirty minutes to no more than six hours.
Claim 28
Dependent Claim
76 words
The apparatus of claim 20 wherein there are a plurality of said guide tubes and the control means performs the functions of causing the source assembly to be moved toward the end portion of each guide tube and positioned a plurality of times at each of a series of preselected positions lying in each guide tube and allowing the source assembly to remain at each of the preselected positions for a plurality of predetermined residence times.
Claim 29
Dependent Claim
36 words
The apparatus of claim 26 wherein the control means performs the function of causing the source assembly to be moved to each of the preselected positions in each of the guide tubes in a selected order.
Claim 30
Dependent Claim
56 words
The apparatus of claim 27 wherein the control means performs the function of causing the source assembly to be moved in the selected order such that the source assembly is moved to each of the preselected positions in each of said guide tubes and then moved to other preselected positions in another of said guide tubes.
Claim 31
Dependent Claim
60 words
The apparatus of claim 27 wherein the control means performs functions of causing the source assembly to be first moved to less than each of the preselected positions in a first of said guide tubes and then moved to a preselected position in another of said guide tubes and then moved to a preselected position in the first guide tube.
Claim 32
Dependent Claim
78 words
The apparatus of claim 26 wherein the control means performs functions of causing the source assembly to be withdrawn from said preselected position in one of said guide tubes to a rest position, and subsequently causing the source assembly to be moved from the rest position to the same said preselected position and allowed to remain at that same said preselected position and allowed to remain at that same said preselected position for a predetermined further residence time.
Claim 33
Dependent Claim
28 words
The apparatus of claim 30 wherein the control means performs the function of causing the source assembly to remain at said rest position for a predetermined rest time.
Claim 34
Dependent Claim
45 words
The apparatus of claim 31 wherein the rest time is a time period between successive radiations of a selected site such that there is a difference in total biological affect of the radiation on normal cells and cancer cells in the effective field of radiation.
Claim 35
Dependent Claim
24 words
The apparatus of claim 32 wherein the rest time is in the range of at least thirty minutes to no more than six hours.
Claim 36
Dependent Claim
28 words
The apparatus of claim 20 wherein the control means performs the function of moving the source assembly to one of said preselected positions from 1 to 140 times.
Claim 37
Dependent Claim
41 words
The apparatus of claim 20 wherein the moving means includes a stepping motor and a transport thread, and the transport thread is attached at one end thereof to the source assembly and at the other end thereof to said stepping motor.
References Cited (Backward Citations)
DE1466774A1
Cited
EP0152124A2
Cited
EP0158630A2
Cited
US4881937A
Cited
US5030194A
Cited
DE3643893A1
Cited
US4851694A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-27 | 1995-07-29 | 1996-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-27 | 1999-07-29 | 2000-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-27 | 2003-07-29 | 2004-01-28 | $7700.00 | Window Closed / Lapsed |