Patent US5039790A successfully refreshed from Google Patents.
US5039790A
Expired / Lapsed
US
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Bioactive fragment of interleukin-1-B that has antagonistic activity
Assignee: Monsanto Co
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Filing: 1989-01-11
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Granted: 1991-08-13
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Expires: 2009-01-11
Abstract
Abstract The present invention discloses a peptide capable of blocking activity of Interleukin-1. The peptide corresponds to the 157-186 amino acid residue of the IL-1 beta molecules.
Inventors
- 👤 Steven P. Adams
- 👤 Joseph W. Bulock
- 👤 Kam F. Fok
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:42
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
18 words
A peptide selected from the group consisting of: ##STR3## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
18 words
A peptide selected from the group consisting of: ##STR3## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
The peptide of claim 1 of the formula: ##STR4##
Claim 4
Dependent Claim
13 words
The peptide of claim 1 in which the peptide is the C-terminal amide.
Claim 5
Dependent Claim
11 words
The peptide of claim 2 comprising the pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
11 words
The peptide of claim 3 comprising the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
32 words
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a peptide selected from the group consisting of: ##STR5## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
32 words
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a peptide selected from the group consisting of: ##STR5## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
23 words
The pharmaceutical composition of claim 6 in which the peptide is selected from the group consisting of: ##STR6## and pharmaceutically acceptable salts thereof.
Claim 10
Dependent Claim
25 words
The pharmaceutical composition of claim 6 in which the peptide is selected from the group consisting of the C-terminal amide and pharmaceutically acceptable salts thereof.
Claim 11
Independent Claim
34 words
A method for blocking IL-1 related physiological responses which comprises administering an IL-1 effective amount of a peptide selected from the group consisting of: ##STR7## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 12
Independent Claim
34 words
A method for blocking IL-1 related physiological responses which comprises administering an IL-1 effective amount of a peptide selected from the group consisting of: ##STR7## the C-terminal amide thereof, and pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim
14 words
The method of claim 9 in which the peptide is of the formula: ##STR8##
Claim 14
Dependent Claim
13 words
The method of claim 9 in which the peptide is the C-terminal amide.
Claim 15
Dependent Claim
16 words
The method of claim 10 in which the peptide is administered as a pharmaceutically acceptable salt.
Claim 16
Dependent Claim
16 words
The method of claim 11 in which the peptide is administered as a pharmaceutically acceptable salt.
Claim 17
Dependent Claim
20 words
The method of claim 9 in which the peptide is administered as a pharmaceutical composition comprising a pharmaceutically acceptable excipient.
References Cited (Backward Citations)
US4762914A
Cited
US4766069A
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US4772685A
Cited
US4994553A
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US4774320A
Cited
EP0237967A2
Cited
US4935343A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-12 | 1995-02-11 | 1995-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-12 | 1999-02-11 | 1999-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-12 | 2003-02-11 | 2003-08-13 | $7700.00 | Window Closed / Lapsed |