US4762914A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Truncated protein of interleukin-1
Assignee: WELLESLEY COLLEGE WELLESLEY MASSACHUSETTS
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Filing: 1985-02-11
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Granted: 1988-08-09
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Expires: 2005-02-11
Abstract
Abstract The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
Inventors
- 👤 Philip E. Auron
- 👤 Andrew C. Webb
- 👤 Lee Gehrke
- 👤 Charles A. Dinarello
- 👤 Lanny J. Rosenwasser
- 👤 Alexander Rich
- 👤 Sheldon M. Wolff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:07
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
8 words
A protein having the following amino acid sequence:
Claim 2
Dependent Claim
8 words
A protein having the following amino acid sequence:
Claim 3
Dependent Claim
9 words
A protein having the following amino acid sequence: ##STR2##
Claim 4
Dependent Claim
9 words
A protein having the following amino acid sequence: ##STR2##
Claim 5
Dependent Claim
9 words
A protein having the following amino acid sequence: ##STR3##
Claim 6
Dependent Claim
9 words
A protein having the following amino acid sequence: ##STR3##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-09 | 1992-02-08 | 1992-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-09 | 1996-02-08 | 1996-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-09 | 2000-02-08 | 2000-08-09 | $7700.00 | Window Closed / Lapsed |