US5035901A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone inducing agent from a human osteosarcoma cell line
Assignee: KANSAS A KANSAS CORP, University of
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Filing: 1987-10-09
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Granted: 1991-07-30
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Expires: 2007-10-09
Abstract
Abstract Human osteosarcoma Saos-2 cell extracts as for example in the form of a killed-cell, defatted cell residue are found to retain bone inducing-agent(s) after freeze-drying. Pellets of this material were found to promote new bone formation. This material is useful therefore for healing bone defects, bone tumors, bone fractures and in promoting bone graft assimilation.
Inventors
- 👤 H. Clarke Anderson
- 👤 Kazuomi Sugamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:15
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K35/00; A61K35/12; A61K35/13; A61K35/32; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/828
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
37 words
Method for inducing bone formation in a mammal which comprises treating a mammal in need of bone formation or healing with an amount of devitalized, freeze dried Saos-2 cells sufficient to promote bone healing or bone formation.
Claim 2
Dependent Claim
37 words
Method for inducing bone formation in a mammal which comprises treating a mammal in need of bone formation or healing with an amount of devitalized, freeze dried Saos-2 cells sufficient to promote bone healing or bone formation.
Claim 3
Dependent Claim
12 words
Method of claim 1, wherein said Saos-2 cells are defatted Saos-2 cells.
Claim 4
Dependent Claim
30 words
Method of claim 1, wherein said mammal is in need of healing of a bone defect, treatment of a bone tumor or of promotion of assimilation of a bone graft.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-29 | 1995-01-28 | 1995-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-29 | 1999-01-28 | 1999-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-29 | 2003-01-28 | 2003-07-30 | $7700.00 | Window Closed / Lapsed |