3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles

Claim 1

A compound having the formula: ##STR18## wherein: R 2 is hydrogen, lower-alkyl, chloro, phenyl or benzoyl (or phenyl or benzoyl substituted by from one to two substituents selected from halo, lower-alkyl, lower-alkoxy, hydroxy, amino, lower-alkylmercapto, lower-alkylsulfinyl or lower-alkylsulfonyl); R 3 is cyclohexyl, lower-alkoxycyclohexyl, phenyl (or phyenyl substituted by from one to two substituents selected from halo, lower-alkoxy, hydroxy, benzyloxy, lower-alkyl, nitro, amino, lower-alkylamino, di-lower-alkylamino, lower-alkoxy-lower-alkylamino, lower-alkanoylamino, benzoylamino, trifluroracetylamino, lower-alkyl-sulfonylamino, carbamylamo, lower-alkylmercapto, lower-alkylsulfinyl, lower-alkylsulfonyl, cyano, formyl and oximinomethylene), methylenedioxyphenyl, 3- or 4-hydroxy-1-piperidinylphenyl, 1-piperazinylphenyl, (1H-imidazol-1-yl)phenyl, (1-pyrrolyl)phenyl, aminomethylphenyl, guanidinylmethylphenyl, N-cyanoguanidinylmethylphenyl, styryl, lower-alkyl-substituted-styryl, fluorosubstituted-styryl, 2- or 4-biphenyl, 1- or 2-naphthyl (or1- or 2-naphthyl substituted by from one to two substituents selected from lower-alkyl, lower alkoxy, hydroxy, bromo, chloro, fluoro, lower-alkoxycarbonyl, carbamyl, cyano, lower-alkyl-mercapto, lower-alkylsulfinyl, lower-alkylsulfonyl and trifluoromethyl), thienyl, furyl, benzofuryl, benzothienyl, quinolyl, or (N-lower-alkyl)pyrrolyl; R 4 is hydrogen or from one to two substituents selected from lower-alkyl, hydroxy, lower-alkoxy and halo in the 4-, 5-, 6- or 7-positions; C=Z is C=O or C=NOH; and N=B is azido, amino, N-lower-alkylamino, N,N-dilower-alkylamino, N-(hydroxy-lower-alkyl)amino, N,N-di-(hydroxy-lower-alkyl)amino, N-lower-alkyl-N-(hydroxy-lower-alkyl)amino, N-(lower-alkoxy-lower-alkyl)amino, N-(halo-n-propyl)amino, 4-morpholinyl, 2-lower-alkyl-4-morpholinyl, 2,6-di-lower-alkyl-4-morpholinyl, 4-thiomorpholinyl, 4-thiomorpholinyl-S-oxide, 4-thiomorpholinyl-S,S-dioxide, 1-piperidinyl, 3-or 4-hydroxy-1-piperidinyl, 3- or 4-lower-alkanoyloxy-1-piperidinyl, 3- or 4-amino-1-piperidinyl, 3- or 4-(N-lower-alkanoylamino)-1-piperidinyl, 2-cyclohexylmethyl-1-piperidinyl, 1pyrrolidinyl, 3-hydroxy-1-pyrrolidinyl, 1-azetidinyl, 1-piperazinyl, 4-lower-alkyl-1piperazinyl, 4-lower-alkanoyl-1-piperazinyl, 4-carbo-lower-alkoxy-1-piperazinyl, hexahydro-4H-1,4-diazepin-4-yl or the N=BN-oxides thereof; or an acid addition salt thereof.