US4229464A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases
Assignee: Roche Diagnostics GmbH
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Filing: 1978-09-18
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Granted: 1980-10-21
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Expires: 1998-09-18
Abstract
Abstract New aminopropanol compounds of the formula <IMAGE> (I) wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or -CONR3R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
Inventors
- 👤 Wolfgang Kampe
- 👤 Kurt Stach, deceased
- 👤 administrator by Werner Plattner
- 👤 Max Thiel
- 👤 Wolfgang Bartsch
- 👤 Karl Dietmann
- 👤 Egon Roesch
- 👤 Wolfgang Schaumann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:46
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/42; A; A61; A61P; A61P25/00; A61P25/02; C07D209/08; C07D209/10; C07D209/12
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
52 words
Amino propanol of the formula ##STR7## wherein R is lower alkyl or cycloalkyl of from 3 to 6 carbon atoms R 1 is pivaloyloxyalkyl, and R 2 is hydrogen, lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl; wherein the alkyl moieties contain up to 6 carbon atoms each; and the pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
52 words
Amino propanol of the formula ##STR7## wherein R is lower alkyl or cycloalkyl of from 3 to 6 carbon atoms R 1 is pivaloyloxyalkyl, and R 2 is hydrogen, lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl; wherein the alkyl moieties contain up to 6 carbon atoms each; and the pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
17 words
Aminopropanol compound as claimed in claim 1 wherein R is alkyl of up to 6 carbon atoms.
Claim 4
Dependent Claim
11 words
Aminopropanol compound as claimed in claim 1 wherein R is cycloalkyl.
Claim 5
Dependent Claim
17 words
Aminopropanol compound as claimed in claim 1 wherein R 1 is pivaloyloxyalkyl and R 2 is hydrogen.
Claim 6
Dependent Claim
9 words
Aminopropanol compound as claimed in claim 1 designated 4-(2-hydroxy-3-tert.-butylamino-propoxy)-2-pivaloyloxymethyl-indole.
Claim 7
Dependent Claim
9 words
Aminopropanol compound as claimed in claim 1 designated 4-(2-hydroxy-3-isopropylamino-propoxy)-2-pivaloyloxymethyl-indole.
Claim 8
Dependent Claim
36 words
Method of combatting or preventing cardiac and circulatory infirmities which method comprises applying to a subject in amounts effective for treatment or prophylaxis of cardiac or circulatory diseases an aminopropanol compound selected from 4-(2-hydroxy-3-tert.-butylamino-propoxy)-2-pivaloyloxymethyl-indole, and 4-(2-hydroxy-3-isopropylamino-propoxy)-2-pivaloyloxymethyl-indole.
Claim 9
Dependent Claim
36 words
Method of combatting or preventing cardiac and circulatory infirmities which method comprises applying to a subject in amounts effective for treatment or prophylaxis of cardiac or circulatory diseases an aminopropanol compound selected from 4-(2-hydroxy-3-tert.-butylamino-propoxy)-2-pivaloyloxymethyl-indole, and 4-(2-hydroxy-3-isopropylamino-propoxy)-2-pivaloyloxymethyl-indole.
Claim 10
Dependent Claim
11 words
Method as claimed in claim 7 wherein said compound is 4-(2-hydroxy-3-tert.-butylamino-propoxy)-2-pivaloyloxymethyl-indole.
Claim 11
Dependent Claim
25 words
Method as claimed in claim 7 wherein said compound is applied at a dosage of 1 to 40 mg up to four times a day.
Claim 12
Dependent Claim
19 words
Method as claimed in claim 7 wherein said compound is applied orally in dosages of 20 to 40 mg.
Claim 13
Dependent Claim
23 words
Method as claimed in claim 7 wherein said compound is applied intravenously at a dosage of from 1 to 5 mg per dosage.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-21 | 1984-04-21 | 1984-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-21 | 1988-04-21 | 1988-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-21 | 1992-04-21 | 1992-10-21 | $7700.00 | Window Closed / Lapsed |