EP0270254A2
Expired / Lapsed
EP
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Gamma irradiation of collagen/mineral mixtures
Assignee: Collagen Aesthetics Inc
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Filing: 1987-11-05
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Granted: —
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Expires: 2007-11-05
Abstract
Abstract A process for sterilization of collagen/mineral compositions using γ radiation is conducted under conditions which produce a product of desired handling and biocompatibility properties.
Inventors
- 👤 Thomas L. Smestad
- 👤 Daniel Prows
- 👤 George H. Chu
- 👤 Diana M. Hendriks
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:59
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/081; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
44 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a compressive modulus of at least 10 N/cm² and a sterility assurance factor of 10⁻⁶ or less.
Claim 2
Dependent Claim
44 words
A biocompatible collagen/mineral composition which comprises a mixture containing 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture, which composition has a compressive modulus of at least 10 N/cm² and a sterility assurance factor of 10⁻⁶ or less.
Claim 3
Dependent Claim
13 words
A composition according to claim 1 which has a moisture content of 0.5-6%.
Claim 4
Dependent Claim
18 words
A composition according to claim 1 or claim 2 wherein the collagen content of the mixture is 2-5%.
Claim 5
Dependent Claim
19 words
A composition according to any one of claims 1 to 3 which has a compressive modulus of 25-45 N/cm².
Claim 6
Dependent Claim
66 words
A process for preparing a biocompatible bone implant preparation having a compressive modulus of at least 10 N/cm² and a sterility factor of 10⁻⁶ or less; which process comprises irradiating with 0.5-4 Mrad γ radiation a collagen/mineral composition which comprises a mixture of 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture and which contains 1-6% moisture during the irradiation.
Claim 7
Dependent Claim
66 words
A process for preparing a biocompatible bone implant preparation having a compressive modulus of at least 10 N/cm² and a sterility factor of 10⁻⁶ or less; which process comprises irradiating with 0.5-4 Mrad γ radiation a collagen/mineral composition which comprises a mixture of 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture and which contains 1-6% moisture during the irradiation.
Claim 8
Dependent Claim
15 words
A process according to claim 5 wherein the composition contains 1-2% moisture during the irradiation.
Claim 9
Dependent Claim
35 words
A process according to claim 5 or claim 6 comprising drying a collagen/mineral composition to a moisture content of less than 1%, and rehydrating the composition to a moisture content of 1-6% prior to irradiation.
Claim 10
Dependent Claim
18 words
A process according to claim 7 comprising rehydrating the composition at 35-45°C at 50-95% RH for 6-24 hours.
Claim 11
Dependent Claim
31 words
A process according to claim 5 or claim 6 comprising heat treating a composition containing 0.5-1% moisture to effect cross-linking corresponding to a compression modulus of 10-45 N/cm² prior to irradiation.
Claim 12
Dependent Claim
19 words
A process according to claim 9 comprising heat treating the composition for 4-24 hours at 60-90°C and 20-80% RH.
Claim 13
Dependent Claim
18 words
A process according to any one of claims 1 to 10 wherein the radiation dosage is 1-3 Mrad.
Claim 14
Independent Claim
41 words
A method of obtaining a collagen/mineral composition of a desired moisture content which comprises drying said mixture to a moisture content of less than 1%, and rehydrating said dried mixture by incubating it at 35-45°C at a relative humidity of 50-80%.
Claim 15
Independent Claim
41 words
A method of obtaining a collagen/mineral composition of a desired moisture content which comprises drying said mixture to a moisture content of less than 1%, and rehydrating said dried mixture by incubating it at 35-45°C at a relative humidity of 50-80%.
Claim 16
Dependent Claim
43 words
A collagen/mineral composition according to any one of claims 1 to 4 or produced by a process according to any one of claims 5 to 12 for use in a method of treatment of the human or animal body by surgery or therapy.
Claim 17
Dependent Claim
50 words
Use of a collagen/mineral composition according to any one of claims 1 to 4 or produced by a process according to any one of claims 5 to 12 in the preparation of a medicament for use in method of treatment of the human or animal body by surgery or therapy.
References Cited (Backward Citations)
No citation records indexed.
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