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US4994553A
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Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies
Assignee: Merck and Co Inc
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Filing: 1988-06-17
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Granted: 1991-02-19
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Expires: 2008-06-17
Abstract
Abstract Several distinct peptide regions of the secreted form of purified human interleukin-1 species pI 6.8 have been found to exhibit characteristics associated with highly immunogenic protein moieties and are used to produce specific anti-peptide antibodies. The antibodies raised against the individual peptides are specific for the peptide used for their production and for IL-1, pI 6.8. The individual antibodies bind to both the precursor of IL-1, pI 6.8 and the mature or extracellular IL-1, pI 6.8.
Inventors
- 👤 John A. Schmidt
- 👤 Joshua S. Boger
- 👤 Ellen B. K. Bayne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:53
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/08; C07K14/00; C07K14/435; C07K14/52; C07K14/54; C07K14/545; C07K16/00; C07K16/18; C07K16/24; C07K16/244; C07K16/245; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6863; G01N33/6869; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/81; Y10S530/812
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
27 words
A peptide having the amino acid sequence ALA PRO VAL ARG SER LEU ASN CYS THR LEU ARG ASP or the amide or acid addition salts thereof.
Claim 2
Dependent Claim
27 words
A peptide having the amino acid sequence ALA PRO VAL ARG SER LEU ASN CYS THR LEU ARG ASP or the amide or acid addition salts thereof.
Claim 3
Dependent Claim
17 words
A peptide immunogen comprising the peptide of claim 1 conjugated to a high molecular weight carrier protein.
Claim 4
Dependent Claim
17 words
The peptide immunogen of claim 2 wherein the high molecular weight carrier protein is keyhole limpet hemocyanin.
Claim 5
Dependent Claim
29 words
A peptide having the amino acid sequence CYS ARG ASP ILE THR ASP PHE THR MET GLN PHE VAL SER SER or the amide or acid addition salts thereof.
Claim 6
Dependent Claim
29 words
A peptide having the amino acid sequence CYS ARG ASP ILE THR ASP PHE THR MET GLN PHE VAL SER SER or the amide or acid addition salts thereof.
Claim 7
Dependent Claim
17 words
A peptide immunogen comprising the peptide of claim 4 conjugated to a high molecular weight carrier protein.
Claim 8
Dependent Claim
17 words
The peptide immunogen of claim 5 wherein the high molecular weight carrier protein is keyhole limpet hemocyanin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-02-18 | 1994-08-20 | 1995-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-02-18 | 1998-08-20 | 1999-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-02-18 | 2002-08-20 | 2003-02-19 | $7700.00 | Window Closed / Lapsed |