US4955377A — Device and method for heating tissue in a patient…

Claim 1

Independent Claim 156 words

Device for heating tissue, comprising a chamber constructed for insertion into a patient's body, an electrically conductive fluid preselected for resistive heating for filling the chamber, a plurality of spaced electrical contacts enclosed within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential between the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, whereby on the basis of I 2 R losses of said radio frequency electric current flowing between the electrical contacts, the fluid can be heated and the fluid in turn can heat the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 2

Dependent Claim 156 words

Device for heating tissue, comprising a chamber constructed for insertion into a patient's body, an electrically conductive fluid preselected for resistive heating for filling the chamber, a plurality of spaced electrical contacts enclosed within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential between the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, whereby on the basis of I 2 R losses of said radio frequency electric current flowing between the electrical contacts, the fluid can be heated and the fluid in turn can heat the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 3

Dependent Claim 55 words

The device of claim 1 wherein said chamber is defined by an expandable wall, the chamber adapted to be empty and the expandable wall collapsed at the time of introduction into the patient and wherein a conduit is adapted to fill the chamber with said fluid after introduction of the chamber into the patient's body.

Claim 4

Dependent Claim 16 words

The device of claim 1 or 2 wherein the chamber is defined by an inflatable balloon.

Claim 5

Dependent Claim 16 words

The device of claim 1 wherein said electrical contacts are radiopaque and serve as radiopaque markers.

Claim 6

Independent Claim 31 words

The device of any of the claims 1 wherein the impedance between a pair of said electrodes, when said chamber is filled with said preselected fluid, is less than 1000 ohms.

Claim 7

Dependent Claim 17 words

The device of claim 5 wherein said impedance is in the range of 50 to 500 ohms.

Claim 8

Dependent Claim 24 words

The device of any of the claim 1 including a power supply constructed to operate at a frequency between 100 khz and 1 Mhz.

Claim 9

Dependent Claim 23 words

The device of claim 7 wherein the electrical potential applied across the contacts by the power source is about 100 volts or less.

Claim 10

Dependent Claim 32 words

The device of claim 7 further comprising a temperature sensor, and a temperature control circuit for controlling the output of the power supply in response to information received from the temperature sensor.

Claim 11

Dependent Claim 36 words

The device of any of the claim 1 wherein a temperature sensor constructed to sense the temperature of said fluid for controllinq the application of said electrical potential to said contacts is located within the chamber.

Claim 12

Dependent Claim 40 words

The device of any of the claim 1 associated with an temperature sensor located outside the chamber in contact with tissue surrounding the chamber for controlling the application of said electrical potential to said contacts is located within the chamber.

Claim 13

Independent Claim 17 words

The device of any of the claims 1 wherein said chamber is filled with a saline solution.

Claim 14

Independent Claim 19 words

The device of any of the claims 1 wherein said chamber is filled with a fluid that is radiopaque.

Claim 15

Independent Claim 17 words

The device of any of the claims 1 sized and constructed for insertion into a blood vessel.

Claim 16

Dependent Claim 23 words

The device of any of the claim 1 sized and constructed for insertion into the body to apply heat to the prostate gland.

Claim 17

Dependent Claim 25 words

The device of any of the claim 1 wherein said chamber is coated with a coating that prevents said chamber from sticking to said tissue.

Claim 18

Dependent Claim 49 words

The device of any of the claim 1 including a power supply adapted to apply said current at a level sufficient to cause localized boiling of said fluid at said electrical contacts, to cause mixing of the fluid in said chamber and produce uniform heating of the chamber wall.

Claim 19

Dependent Claim 40 words

The device of claim 17 including a pressure transducer exposed to sense fluid pressure in said chamber and means constructed and arranged to control the energy applied to said electrical contacts in response to information received from the pressure transducer.

Claim 20

Dependent Claim 56 words

The device of any of the claim 1 associated with a power supply controlled by a thermister sensor, and a control constructed and arranged to operate alternately in a power application mode in which rf potential is applied to said contacts and a sensing mode during which application of rf potential to said contacts is disrupted

Claim 21

Dependent Claim 62 words

The device of any of the claim 1 including a thermister exposed to fluid in said chamber, said thermister connected to one of said electrical contacts, said device adapted to be used with a power supply controlled to alternately apply potential to said electrical contacts and to sense the temperature of the fluid in the absence of rf potential on the contacts.

Claim 22

Independent Claim 160 words

A method for heating tissue, comprising inserting into a patient's body a chamber containing electrically conductive fluid preselected for resistive heating, there being a plurality of spaced electrical contacts encodes within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential to the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, and applying radio frequency potential between said electrical contacts, whereby on the basis of I 2 R losses of said radio frequency electric current flowing between the electrical contacts, the fluid is heated and the fluid in turn heats the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 23

Independent Claim 160 words

A method for heating tissue, comprising inserting into a patient's body a chamber containing electrically conductive fluid preselected for resistive heating, there being a plurality of spaced electrical contacts encodes within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential to the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, and applying radio frequency potential between said electrical contacts, whereby on the basis of I 2 R losses of said radio frequency electric current flowing between the electrical contacts, the fluid is heated and the fluid in turn heats the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 24

Dependent Claim 27 words

The method of claim 21, wherein said radio frequency potential applied across said contacts is at frequency in the range between about 100 khz and 1 Mhz.

Claim 25

Dependent Claim 21 words

The method of claim 21, including controlling the electrical current between the electrical contacts to induce localized boiling at the contacts.

Claim 26

Independent Claim 191 words

A method of constant temperate heating, comprising inserting into a patient's body a chamber containing electrically conductive fluid preselected for resistive heating, there being a plurality of electrical contacts enclosed within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential to the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, applying radio frequency potential, between said electrical contacts, monitoring temperature at a point influenced by the temperature of said liquid and in response thereto controlling the radio frequency energy applied to said electrical contacts to maintain said temperature constant, whereby on the basis of I 2 R losses of said controlled radio frequency electric current flowing between the electrical contacts, the fluid is heated and the fluid in turn heats the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 27

Independent Claim 191 words

A method of constant temperate heating, comprising inserting into a patient's body a chamber containing electrically conductive fluid preselected for resistive heating, there being a plurality of electrical contacts enclosed within the chamber and a corresponding plurality of conductors for connecting the electrical contacts to a power supply for applying a radio frequency electrical potential to the contacts, said contacts being exposed to the fluid-containing space of said chamber so that said radio frequency electrical potential can cause current to flow through fluid between the contacts, said chamber and said contacts being cooperatively constructed and arranged to cause said current to be confined to said fluid within the chamber, applying radio frequency potential, between said electrical contacts, monitoring temperature at a point influenced by the temperature of said liquid and in response thereto controlling the radio frequency energy applied to said electrical contacts to maintain said temperature constant, whereby on the basis of I 2 R losses of said controlled radio frequency electric current flowing between the electrical contacts, the fluid is heated and the fluid in turn heats the surrounding tissue by thermal conduction through a wall of the chamber.

Claim 28

Dependent Claim 23 words

The method of claim 24 wherein said chamber comprises a balloon on a catheter introduced into a lumen or cavity of the body.

Claim 29

Dependent Claim 57 words

The method of claim 24 or 25 wherein temperature at a point in the body adjacent said chamber is monitored and used to control the application of energy to said electrodes to maintain temperature at said point constant for a selected duration, on the basis of thermal transfer from liquid heated in said balloon to said point.

Claim 30

Dependent Claim 58 words

The method of claim 24 or 25 wherein temperature of the liquid in said chamber is monitored and used to control the application of energy to said electrodes to maintain temperature of said fluid constant at a set point whereby it is assured that tissue in the vicinity of said chamber is not heated above said set point.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-09-10	1994-03-12	1994-09-11	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-09-10	1998-03-12	1998-09-11	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-09-10	2002-03-12	2002-09-11	$7700.00	Window Closed / Lapsed

Device and method for heating tissue in a patient's body

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