US4951673A
Expired / Lapsed
US
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Magnetic resonance imaging with perfluorocarbon hydrides
Assignee: PFC Therapeutics LLC
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Filing: 1988-08-19
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Granted: 1990-08-28
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Expires: 2008-08-19
Abstract
Abstract Perfluorocarbon hydrides, either alone or in combination with other perfluorocarbon compounds, may be introduced into a non-vascular animal space as a contrast agent in magnetic resonance imaging (MRI), computed tomography (CT) or conventional x-ray procedures. In the image generated by these systems, the fluorocarbon introduced into the space is contrasted with the remaining body tissues or spaces to distinguish the fluorocarbon-occupied space from other tissues and spaces. Perfluoroctyl hydride vaporizes at body temperature, and its gas phase, which also provides an effective contrast to tissues, is disclosed in imaging areas of comparatively large void volume while using a lower fluorocarbon dose then than required for fluid fluorocarbon. Perfluorocarbon hydrides offer less radiodensity to x-ray imaging and less hydrogen density to MRI imaging, and are disclosed as diluents for perfluorocarbon bromides in applications where concentrated brominated compounds are found to cause imaging artifacts. Perfluorocarbon emulsions comprising a mixture of perfluorocarbon bromide and at least 0.1% perfluorocarbon hydride are disclosed for intravascular use as a contrast agent or for oxygen transport.
Inventors
- 👤 David M. Long
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:00
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/05; A61B5/055; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0461; A61K49/0471; A61K49/06; A61K49/18; A61K49/1806; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
75 words
A method for imaging a selected non-vascular body space of an animal body using magnetic resonance imaging, comprising: introducing an imaging composition comprising a perfluorocarbon hydride having from 6 to 10 carbon atoms into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue with a magnetic resonance proton imaging system to contrast the fluorocarbon-occupied space with surrounding space or tissue containing substantially greater concentrations of protons.
Claim 2
Independent Claim
75 words
A method for imaging a selected non-vascular body space of an animal body using magnetic resonance imaging, comprising: introducing an imaging composition comprising a perfluorocarbon hydride having from 6 to 10 carbon atoms into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue with a magnetic resonance proton imaging system to contrast the fluorocarbon-occupied space with surrounding space or tissue containing substantially greater concentrations of protons.
Claim 3
Dependent Claim
12 words
The method of claim 1, wherein said perfluorocarbon hydride comprises perfluoroctyl hydride.
Claim 4
Dependent Claim
15 words
A method according to claim 1, wherein said imaging composition further comprises a perfluorocarbon halide.
Claim 5
Dependent Claim
18 words
The method according to claim 3, wherein said imaging composition comprises perfluoroctyl bromide in combination with perfluoroctyl hydride.
Claim 6
Independent Claim
20 words
A method according to any one of claims 1, 2, 3 or 4, wherein said introducing step comprises oral introduction.
Claim 7
Independent Claim
37 words
A method according to any one of claims 1, 2, 3 or 4, further comprising the step, before said imaging step, of permitting said imaging composition to at least partially vaporize in situ within said body space.
Claim 8
Dependent Claim
17 words
A method according to claim 6, wherein said body space comprises the bowel of said animal body.
Claim 9
Dependent Claim
17 words
A method of claim 6, wherein said body space is the peritoneal cavity of said animal body.
Claim 10
Independent Claim
87 words
A method for imaging a selected non-vascular body space of an animal body by computed tomography, comprising: introducing an imaging composition, comprising a mixture of a perfluorocarbon bromide having from 6 to 10 carbon atoms and a perfluorocarbon hydride having from 6 to 10 carbon atoms, into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue with a computed tomography system to contrast the fluorocarbon-occupied space with surrounding space or tissue containing substantial concentrations of less radio-dense material.
Claim 11
Independent Claim
87 words
A method for imaging a selected non-vascular body space of an animal body by computed tomography, comprising: introducing an imaging composition, comprising a mixture of a perfluorocarbon bromide having from 6 to 10 carbon atoms and a perfluorocarbon hydride having from 6 to 10 carbon atoms, into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue with a computed tomography system to contrast the fluorocarbon-occupied space with surrounding space or tissue containing substantial concentrations of less radio-dense material.
Claim 12
Dependent Claim
13 words
A method according to claim 9, wherein said introducing step comprises oral introduction.
Claim 13
Dependent Claim
29 words
A method according to claim 9, further comprising the step, before said imaging steps, of permitting said fluorocarbon to at least partially vaporize in situ within said body space.
Claim 14
Dependent Claim
16 words
The method of claim 9, wherein said body space comprises the bowel of said animal body.
Claim 15
Dependent Claim
17 words
The method of claim 9, wherein said body space comprises the peritoneal cavity of said animal body.
Claim 16
Independent Claim
71 words
A method for imaging a selected non-vascular body space of an animal body by radiography, comprising: introducing an imaging composition comprising a perflucrocarbons hydride having from 6 to 10 carbon atoms into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue by radiography to contrast the fluorocarbon-occupied space with surrounding space or tissue containing a substantial concentration of less radio dense material.
Claim 17
Independent Claim
71 words
A method for imaging a selected non-vascular body space of an animal body by radiography, comprising: introducing an imaging composition comprising a perflucrocarbons hydride having from 6 to 10 carbon atoms into the non-vascular body space to at least partially fill the space; and imaging the space and surrounding tissue by radiography to contrast the fluorocarbon-occupied space with surrounding space or tissue containing a substantial concentration of less radio dense material.
Claim 18
Dependent Claim
17 words
The method of claim 14, wherein said imaging composition comprises perfluoroctyl bromide in combination with perfluorocarbon hydride.
Claim 19
Dependent Claim
15 words
A method according to claim 14 or 15, wherein said introducing step comprises oral introduction.
Claim 20
Dependent Claim
32 words
A method according to claim 14 or 15, further comprising the steps, before said imaging steps, of permitting said imaging composition to at least partially vaporize in situ within said body space.
Claim 21
Dependent Claim
15 words
The method of claim 17, wherein said body space comprises the bowel of said animal.
Claim 22
Dependent Claim
16 words
The method of claim 17, wherein said body space comprises the peritoneal cavity of said animal.
Claim 23
Independent Claim
20 words
A method according to any one of claims 1, 9 or 14, wherein said imaging composition further comprises perfluorohexyl bromide.
Claim 24
Independent Claim
51 words
A method according to any one of claims 1, 9 or 14, wherein said perfluorocarbon imaging composition is in the form of an emulsion comprising a physiologically acceptable aqueous phase, said perfluorocarbon in an amount of from 20 to 125% weight per volume, and an effective amount of an emulsifying agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-27 | 1994-02-26 | 1994-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-27 | 1998-02-26 | 1998-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-27 | 2002-02-26 | 2002-08-28 | $7700.00 | Window Closed / Lapsed |