Patent US4937323A successfully refreshed from Google Patents.
US4937323A
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Method and apparatus for lidc enhanced wound healing using biocompatible tissue ingrowth implants
Assignee: Rutgers Health
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Filing: 1988-06-13
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Granted: 1990-06-26
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Expires: 2008-06-13
Abstract
Abstract A therapeutic method for treating wounds by dressing the wound with a biocompatible biodegradable collagen tissue product and applying Low Intensity Direct Current (LIDC) to the product. The devices of the invention include biocompatible biodegradable collagen tissue products having means for the application of LIDC to the dressed wound.
Inventors
- 👤 Frederick H. Silver
- 👤 Michael G. Dunn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:51
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61K; A61K9/00; A61K9/70; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/425; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/58; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
52 words
A therapeutic method for the treatment of wounds comprising dressing a wound with a biocompatible biodegradable collagen porous sponge product and applying cathodic low Intensity Direct Current (LIDC) through means for application of cathodic LID current, fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 2
Dependent Claim
52 words
A therapeutic method for the treatment of wounds comprising dressing a wound with a biocompatible biodegradable collagen porous sponge product and applying cathodic low Intensity Direct Current (LIDC) through means for application of cathodic LID current, fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 3
Dependent Claim
14 words
The method of claim 1, wherein the LIDC is delivered via a cathodic LIDC.
Claim 4
Dependent Claim
17 words
The method of claim 2, wherein the current of the LIDC is at least about 20 microamps.
Claim 5
Dependent Claim
19 words
The method of claim 3, wherein the current of the LIDC is between about 20 and about 100 microamps.
Claim 6
Dependent Claim
11 words
The method of claim 2, wherein the LIDC is applied continuously.
Claim 7
Dependent Claim
17 words
The method of claim 5, wherein the LIDC is applied continuously until maximum wound healing is achieved.
Claim 8
Dependent Claim
40 words
The method of claim 1, which additionally comprises first dressing the wound with a biodegradable collagen flake or biodegradable powder product before dressing the wound with a biocompatible biodegradable collagen porous sponge product prior to the application of LIDC stimulation.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein the wound is a burn.
Claim 10
Dependent Claim
12 words
The method of claim 1, wherein the wound is a skin ulcer.
Claim 11
Dependent Claim
45 words
A therapeutic collagen dressing for the treatment of wound which comprises a biocompatible biodegradable collagen porous sponge product and means for the application of cathodic LIDC stimulation to promote fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 12
Dependent Claim
45 words
A therapeutic collagen dressing for the treatment of wound which comprises a biocompatible biodegradable collagen porous sponge product and means for the application of cathodic LIDC stimulation to promote fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 13
Dependent Claim
17 words
The dressing of claim 10, wherein the means for the application of LIDC stimulation is an electrode.
Claim 14
Dependent Claim
11 words
The dressing of claim 10, wherein the electrode is a cathode.
Claim 15
Dependent Claim
12 words
The dressing of claim 12, wherein the cathode is a carbon cathode.
Claim 16
Dependent Claim
14 words
The dressing of claim 13, wherein the carbon cathode is formed from carbon fibers.
Claim 17
Dependent Claim
13 words
The dressing of claim 14, wherein the carbon fibers are braided carbon fibers.
Claim 18
Dependent Claim
12 words
The dressing of claim 12, wherein the cathode is a metal cathode.
Claim 19
Dependent Claim
12 words
The dressing of claim 16, wherein the cathode metal is stainless steel.
Claim 20
Dependent Claim
13 words
The dressing of claim 16, wherein the cathode metal is a noble metal.
Claim 21
Dependent Claim
21 words
The dressing of claim 18, wherein the noble metal is selected from the group consisting of gold, silver, platinum and palladium.
Claim 22
Dependent Claim
21 words
The dressing of claim 12, wherein the cathode physical shape is selected from the group consisting of wire, plate and mesh.
Claim 23
Dependent Claim
30 words
The dressing of claim 10, wherein the means for the application of LIDC stimulation comprises metal particles dispersed throughout the implant in sufficient quantity to render the implant electrically conductive.
Claim 24
Dependent Claim
12 words
The dressing of claim 21, wherein the metal particles are stainless steel.
Claim 25
Dependent Claim
13 words
The dressing of claim 21, wherein the metal particles are noble metal particles.
Claim 26
Dependent Claim
22 words
The dressing of claim 23, wherein the noble metal particles are selected from the group consisting of gold, silver, platinum and palladium.
Claim 27
Dependent Claim
18 words
The dressing of claim 10, wherein the means for the application of LIDC stimulation is an electrolyte solution.
Claim 28
Dependent Claim
39 words
A biocompatible biodegradable collagen porous sponge product in a wound, said product having means for the application of cathodic LIDC stimulation to promote fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 29
Dependent Claim
39 words
A biocompatible biodegradable collagen porous sponge product in a wound, said product having means for the application of cathodic LIDC stimulation to promote fibroblast ingrowth and collagen fiber alignment near the means for the application of the cathodic current.
Claim 30
Dependent Claim
14 words
The therapeutic collagen dressing of claim 10 which is an implant into the wound.
Claim 31
Dependent Claim
20 words
The therapeutic collagen dressing of claim 10 wherein the promotion of the collagen fiber alignment is in a biaxial orientation.
Claim 32
Dependent Claim
25 words
The therapeutic collagen dressing of claim 10 wherein means for the application of the cathodic stimulation is an electric current at least about 20 microamps.
Claim 33
Dependent Claim
17 words
The therapeutic collagen of claim 29 wherein the current is between about 20 and about 100 microamps.
Claim 34
Dependent Claim
20 words
The therapeutic collagen dressing of claim 10 wherein the means for cathodic stimulation are positioned externally to the wound dressing.
Claim 35
Dependent Claim
17 words
The therapeutic collagen dressing of claim 10 wherein the collagen product is constituted of collagen powder particles.
Claim 36
Dependent Claim
25 words
The therapeutic collagen dressing of claim 10 wherein the means for the application of the cathodic current promotes also increased fibroblast density near said means.
Claim 37
Dependent Claim
19 words
The therapeutic collagen dressing of claim 14 wherein the carbon fibers are inert and do not release metallic ions.
Claim 38
Dependent Claim
16 words
The therapeutic collagen dressing of claim 10 wherein the wound is a burn or skin ulcer.
References Cited (Backward Citations)
US3893462A
Cited
US3893462B1
Cited
US3915151A
Cited
US4233965A
Cited
US4461300A
Cited
US4528265A
Cited
US4556051A
Cited
US4674482A
Cited
US4817594A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-25 | 1993-12-25 | 1994-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-25 | 1997-12-25 | 1998-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-25 | 2001-12-25 | 2002-06-26 | $7700.00 | Window Closed / Lapsed |