Patent US4933178A successfully refreshed from Google Patents.
US4933178A
Expired / Lapsed
US
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Metal-based antimicrobial coating
Assignee: Biointerface Technologies Inc
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Filing: 1988-10-07
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Granted: 1990-06-12
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Expires: 2008-10-07
Abstract
Abstract A medical device with an antimicrobial coating that is safe, effective, photostable and readily manufacturable can be produced by applying a composition to at least one body fluid-contacting surface of the device such that a solid coating is provided on that surface, the coating composition comprising an oligodynamic metal salt of a sulfonylurea, a polymeric material, at least one acid compound selected from the group consisting of a water-soluble carboxylic acid and water-insoluble carboxylic acid, and a carrier liquid in which foregoing components are soluble. The antimicrobial coating accommodates variation in the release of antimicrobial metal ions as a function of the intended use for a medical device to which the coating is applied.
Inventors
- 👤 Christopher C. Capelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:22
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A01; A01N; A01N59/00; A01N59/16; A61L15/00; A61L15/16; A61L15/42; A61L15/46; A61L17/00; A61L17/005; A61L27/00; A61L27/50; A61L27/54; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/204; A61L2300/21; A61L2300/40; A61L2300/404
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
77 words
A medical device comprising (a) a substrate presenting a surface suitable for contact with a body fluid and (b) an antimicrobial coating provided on said surface, said coating comprising an oligodynamic metal salt of a sulfonylurea, a polymeric material and at least one acid compound selected from the group consisting of a water-soluble carboxylic acid and a water-insoluble carboxylic acid, said device being suitable for extended contact with a body, of a patient or with body fluids.
Claim 2
Dependent Claim
77 words
A medical device comprising (a) a substrate presenting a surface suitable for contact with a body fluid and (b) an antimicrobial coating provided on said surface, said coating comprising an oligodynamic metal salt of a sulfonylurea, a polymeric material and at least one acid compound selected from the group consisting of a water-soluble carboxylic acid and a water-insoluble carboxylic acid, said device being suitable for extended contact with a body, of a patient or with body fluids.
Claim 3
Dependent Claim
14 words
The device of claim 1, wherein said sulfonylurea is tolbutamide, acetohexamide, tolazamide or chlorpropamide.
Claim 4
Dependent Claim
28 words
The device of claim 1, wherein said polymeric material has MVTR value in the range of about 100 to 2500 g/m 2 / twenty-four hours/mil of membrane thickness.
Claim 5
Independent Claim
21 words
The device of claim wherein said polymeric material comprises polyurethane, polyvinylchloride, nylon, polystyrene, polyethylene, polyvinyl alcohol, polyvinyl acetate, silicone and polyester.
Claim 6
Dependent Claim
24 words
The device of claim 1, wherein said water-soluble carboxylic acid is citric acid, glutamic acid, glucoheptonic acid, acetic acid, propionic acid or butyric acid.
Claim 7
Independent Claim
32 words
The device of claim -, wherein said water-insoluble carboxylic acid comprises stearic acid, capric acid, lauric acid, myristic acid, palmitic acid, arachidic acid, cholic acid, deoxycholic acid, taurocholic acid or glycocholic acid.
Claim 8
Dependent Claim
28 words
The device of claim 1, wherein said acid compound is present in an amount rendering said coating light-stable and effecting controlled release of metal ions from said coating.
Claim 9
Dependent Claim
26 words
The device of claim 1, wherein said acid compound is present in a molar ratio, relative to said metal salt, that ranges up to about 3:1.
Claim 10
Dependent Claim
29 words
The device of claim 1, wherein said metal salt of a sulfonylurea contains at least one metal selected from the group consisting of silver, gold, zinc, platinum and copper.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-11 | 1993-12-11 | 1994-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-11 | 1997-12-11 | 1998-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-11 | 2001-12-11 | 2002-06-12 | $7700.00 | Window Closed / Lapsed |