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US4906465A
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Antithrombogenic devices containing polysiloxanes
Assignee: Massachusetts Institute of Technology
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Filing: 1988-03-16
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Granted: 1990-03-06
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Expires: 2008-03-16
Abstract
Abstract A crosslinked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane is described. These materials demonstrate low in vivo platelet retention as well as a low thrombogenicity. As such, they can provide antithrombogenic properties to blood contacting devices such as catheters, artificial hearts, ventricular grafts and cardiovascular suture.
Inventors
- 👤 Elliot L. Chaikof
- 👤 Cynthia Sung
- 👤 Edward W. Merrill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:02
CPC Classifications
C; C08; C08G; C08G77/00; C08G77/42; C08G77/46; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/2036; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L33/06; A61L33/068; C02; C02F; C02F1/00; C02F1/28; C02F1/285
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
37 words
A device for use with blood wherein all surfaces which contact blood comprise a crosslinked polymer network comprising the reaction product of a polyethylene oxide and a glycidoxypropylsiloxane having between 3 and 25 glycidoxypropyl units per molecule.
Claim 2
Independent Claim
37 words
A device for use with blood wherein all surfaces which contact blood comprise a crosslinked polymer network comprising the reaction product of a polyethylene oxide and a glycidoxypropylsiloxane having between 3 and 25 glycidoxypropyl units per molecule.
Claim 3
Dependent Claim
12 words
A device as in claim 1 wherein the glycidoxypropylsiloxane is a polyglycidoxypropylmethylsiloxane.
Claim 4
Dependent Claim
14 words
A device as in claim 1 wherein the glycidoxypropylsiloxane is a poly (glycidoxypropylmethylsiloxane/dimethylsiloxane) copolymer.
Claim 5
Dependent Claim
35 words
A device as in claim 1 wherein the polyethylene oxide is selected from the group consisting of dihydroxy polyethylene oxide, polyethylene glycol monomethyl ether, polyethylene glycol monoethyl ether, monoamino polyethylene oxide and diamino polyethylene oxide.
Claim 6
Dependent Claim
20 words
A device as in claim 1 wherein the polyethylene oxide has a molecular weight between about 2,000 and about 20,000.
Claim 7
Dependent Claim
24 words
A device as in claim 5 wherein the polyethylene oxide is selected from the group consisting of 2K PEO, 8K PEO and 20K PEO.
Claim 8
Dependent Claim
22 words
A device as in claim 1 wherein the crosslinked polymer network comprises between about 35% and about 65% polyethylene oxide by weight.
Claim 9
Dependent Claim
41 words
A device as in claim 1 wherein said device is selected from the group consisting of in vivo blood contacting vascular prostheses, artificial hearts, ventricular assist devices, intraaortic balloon pumps, pulmonary artery catheters, ventricular patches, cardiovascular suture and metabolic support catheters.
Claim 10
Dependent Claim
26 words
A device as in claim 1 wherein said device is selected from the group consisting of blood diagnosis apparatus, blood treatment apparatus and blood storage apparatus.
Claim 11
Dependent Claim
23 words
A device as in claim 9 wherein said device is selected from the group consisting of hemodialysis membranes and membranes for extracorporeal oxygenators.
Claim 12
Dependent Claim
46 words
In a device which contacts blood characterized by a need to prevent thrombus formation, the improvement which comprises providing all surfaces which contact blood with a covering comprising the reaction product of a polyethylene oxide and glycidoxypropylsiloxane having between 3 and 25 gylcidoxypropyl units per molecule.
Claim 13
Dependent Claim
46 words
In a device which contacts blood characterized by a need to prevent thrombus formation, the improvement which comprises providing all surfaces which contact blood with a covering comprising the reaction product of a polyethylene oxide and glycidoxypropylsiloxane having between 3 and 25 gylcidoxypropyl units per molecule.
Claim 14
Independent Claim
38 words
A device for use with blood wherein all surfaces which contact blood comprise a cross-linked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane having between about 3 and 25 glycidoxypropyl units per molecule.
Claim 15
Independent Claim
38 words
A device for use with blood wherein all surfaces which contact blood comprise a cross-linked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane having between about 3 and 25 glycidoxypropyl units per molecule.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |