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US4861588A Expired / Lapsed US ⏱️ 0.0 years remaining

Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers

Assignee: California Institute of Technology
•
Filing: 1986-04-28
•
Granted: 1989-08-29
•
Expires: 2006-04-28
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Abstract

Abstract A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

Inventors

  • 👤 Alexander R. Neurath
  • 👤 Stephen B. H. Kent

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 13:11
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/62; A61K47/64; A61K47/645; A61K47/69; A61K47/6905; A61K47/6911; A61K9/00; A61K9/10; A61K9/127; A61K9/1271; C07K16/00; C07K16/08; C07K16/081; C07K16/082; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/576; G01N33/5761; A61K39/00; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/223

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 91 words
A Hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre- S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occuring envelope protein of Hepatitis B virus, wherein the peptide is selected from the group consisting of pre-S (12-47), pre- S(21-47), pre-S (120-153), pre S (132-137), pre-S (53-73) and pre-S (128-139), whrein said peptide additionally comprises and amino acid sequence having no more than three amino acids, said sequence containing Cys at one end thereof.
Claim 2
Dependent Claim 91 words
A Hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre- S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occuring envelope protein of Hepatitis B virus, wherein the peptide is selected from the group consisting of pre-S (12-47), pre- S(21-47), pre-S (120-153), pre S (132-137), pre-S (53-73) and pre-S (128-139), whrein said peptide additionally comprises and amino acid sequence having no more than three amino acids, said sequence containing Cys at one end thereof.
Claim 3
Dependent Claim 20 words
A hepatitis B peptide according to claim 1, wherein the sequence is Gly-Gly-Cys at the C terminal of said peptide.
Claim 4
Dependent Claim 23 words
A hepatitis B peptide according to claim 1, wherein the sequence is Cys - Gly - Gly at the N-terminal of said peptide.
Claim 5
Dependent Claim 71 words
A hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occurring envelope protein of hepatitis B virus, wherein the peptide additionally comprises at either end of the peptide an amino sequence having no more than three amino acids, said sequence containing Cys at one end thereof.
Claim 6
Dependent Claim 71 words
A hepatitis B peptide comprising an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus, said peptide not comprising a naturally occurring envelope protein of hepatitis B virus, wherein the peptide additionally comprises at either end of the peptide an amino sequence having no more than three amino acids, said sequence containing Cys at one end thereof.
Claim 7
Dependent Claim 20 words
A hepatitis B peptide according to claim 4, wherein the sequence is Gly-Gly-Cys at the C terminal of said peptide.
Claim 8
Dependent Claim 24 words
A hepatitis B peptide according to claim 4, wherein the sequence is Cys - Gly - Gly at the N-terminal of the said peptide.

References Cited (Backward Citations)

GB1414480A Cited
US4428941A Cited
US4415491A Cited
JPS58194897A Cited
EP0154902A2 Cited
US4599230A Cited
EP0171260A2 Cited
EP0180012A1 Cited
US4683136A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-08-28 1993-02-27 1993-08-29 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-08-28 1997-02-27 1997-08-29 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-08-28 2001-02-27 2001-08-29 $7700.00 Window Closed / Lapsed

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