Patent US4832034A successfully refreshed from Google Patents.
US4832034A
Expired / Lapsed
US
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Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids
Assignee: Individual
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Filing: 1987-04-09
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Granted: 1989-05-23
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Expires: 2007-04-09
Abstract
Abstract An anisotropic hollow fiber membrane is utilized to sample fluids for selected substances by convective flow of liquid and such substances, with conduct of the liquid to a sensor for analysis for such substances, to permit monitoring, particularly of body fluids, for such substances with short response times.
Inventors
- 👤 Vincent B. Pizziconi
- 👤 Bruce C. Towe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:53
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/14525; A61B5/14528; A61B5/68; A61B5/6801; A61B5/6802; A61B5/681; A61B5/6846; A61B5/6847; A61B5/686; B; B01; B01D; B01D63/00; B01D63/02
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
91 words
A method of sampling materials in a body fluid for analysis comprising contacting the fluid with a hollow fiber of porous semipermeable asymmetric membrane with skin on the outside, of pore size permitting flow of body fluid water and desired analate to the inside of the fiber, 2nd causing such flow whereby the fluid in the inside of the fiber is essentially in instantaneous equilbrium or equivalency with the body fluid with respect to the desired analate, and the fluid in the fiber lumen is available for analysis of the analate.
Claim 2
Independent Claim
91 words
A method of sampling materials in a body fluid for analysis comprising contacting the fluid with a hollow fiber of porous semipermeable asymmetric membrane with skin on the outside, of pore size permitting flow of body fluid water and desired analate to the inside of the fiber, 2nd causing such flow whereby the fluid in the inside of the fiber is essentially in instantaneous equilbrium or equivalency with the body fluid with respect to the desired analate, and the fluid in the fiber lumen is available for analysis of the analate.
Claim 3
Dependent Claim
12 words
The method of claim 1 in which the body fluid is blood.
Claim 4
Dependent Claim
11 words
The method of claim 2 in which glucose is the analate.
Claim 5
Dependent Claim
33 words
The method of claim 2 in which glucose is the analate and glucose in the filtrate is reacted in the present of glucose oxidase to form hydrogen peroxide for determination by electrical means.
Claim 6
Dependent Claim
34 words
The method of claim 2 in which the hollow fiber membrane is positioned so that it penetrates the wall of a blood vessel and it has a portion of itslength within the blood vessel.
Claim 7
Dependent Claim
42 words
The method of claim 1 in which the extra-corporeal end of the hollow fiber is within a few inches of an extra-corporeal means for sensing analate in the fiber filtrate and convective filtrate flow is directed thereto unaided by any carrier fluid.
Claim 8
Dependent Claim
27 words
The method of claim 3 in which measurement of glucose can be obtained with less than 1.0 c.c. of body fluid having been removed from the body.
Claim 9
Dependent Claim
14 words
The method of claim 1 in which analate readings are available on continuous basis.
Claim 10
Dependent Claim
28 words
The method of claim 2 in which transmembrane pressure is regulated so that fluid containing analate crosses the fiber membrane to the lumen in less than 30 seconds.
Claim 11
Dependent Claim
21 words
The method of claim 1 in which the fluid in the lumen flows to an outlet from the lumen for analysis.
Claim 12
Dependent Claim
19 words
The method of claim 2 in which glucose readings are obtained responsive to blood glucose concentrations within 30 seconds.
Claim 13
Dependent Claim
32 words
The method of claim 3 in which the filtrate in the lumen flows through a gas permeable tubing containing glucose oxidase so that glucose is reacted in the presence of excess oxygen.
Claim 14
Independent Claim
92 words
A device for sampling and analyzing complex fluids comprising a hollow membrane fiber means for contacting such complex fluids, such hollow fiber being of porous semipermeable anisotropic membrane with skin on the outside of pore size permitting flow of complex fluid water and desired analate to the inside of the fiber, whereby liquid in the fiber lumen is essentially instantaneously in equilibrium or equivalency with the complex fluid with respect to the desired analate, and flow means connecting the fiber lumen to sensing means for determination of the analate in the liquid.
Claim 15
Independent Claim
92 words
A device for sampling and analyzing complex fluids comprising a hollow membrane fiber means for contacting such complex fluids, such hollow fiber being of porous semipermeable anisotropic membrane with skin on the outside of pore size permitting flow of complex fluid water and desired analate to the inside of the fiber, whereby liquid in the fiber lumen is essentially instantaneously in equilibrium or equivalency with the complex fluid with respect to the desired analate, and flow means connecting the fiber lumen to sensing means for determination of the analate in the liquid.
Claim 16
Dependent Claim
51 words
The device of claim 13 designed for sampling and analyzing body fluids and in which the hollow fiber membrane has porosity such as to permit passage of blood water and glucose but substantially prevents passage of materials of molecular weight over 20,000 while being permeable to materials of lower molecular weight.
Claim 17
Dependent Claim
25 words
The device of claim 13 in which the semipermeable skin of the hollow fiber has pores mainly in the range of 25 to 200 angstroms.
Claim 18
Dependent Claim
23 words
The device of claim 13 in which the hollow fiber membrane is of noningesting material with ultrafiltranteion characteristics that are stable with time.
Claim 19
Dependent Claim
16 words
The device of claim 13 in which the fiber membrane is of polyurethane or polyamide material.
Claim 20
Independent Claim
49 words
A method of sampling materials in a complex fluid comprising contacting the complex fluid with a filtration membrane means providing bulk solvent flow and filtrate collection for analysis of complex fluid fractions, with the membrane being an asymmetric, non-ingesting mebrane with skin on the outside contacting the complex fluid.
Claim 21
Independent Claim
49 words
A method of sampling materials in a complex fluid comprising contacting the complex fluid with a filtration membrane means providing bulk solvent flow and filtrate collection for analysis of complex fluid fractions, with the membrane being an asymmetric, non-ingesting mebrane with skin on the outside contacting the complex fluid.
Claim 22
Dependent Claim
44 words
The method of claim 5 in which the filtrate in the lumen flows through a gas-permeable enzyme-packed tubing for generation of hydrogen peroxide proportional to the glucose and then flows past a reference electrode and polarographic electrode generating current proportional to the hydrogen peroxide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |