US4822336A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood glucose level sensing
Assignee: Individual
•
Filing: 1988-03-04
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Granted: 1989-04-18
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Expires: 2008-03-04
Abstract
Abstract A method of sensing blood glucose levels in the steps of passing glucose from a peritoneal fluid through a semi-permeable membrane and into a closed chamber, metabolizing the passed glucose in the closed chamber with a yeast suspension to produce a level of carbon dioxide and detection of the level of carbon dioxide, and controlled insulin infusion into blood as a consequence of detected carbon dioxide level. Implantable apparatus is also provided for carrying out the method within a body of live tissue.
Inventors
- 👤 John DiTraglia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:24
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
100 words
In a method of sensing blood glucose levels within a body of live tissue having peritoneal fluid therein for the control of insulin infusion into the body, the steps of: (a) passing glucose from the peritoneal fluid through a semipermeable membrane and into a closed chamber; (b) reacting the glucose passed into said closed chamber with a yeast suspension within the chamber to produce a level of carbon dioxide in said closed chamber; (c) detecting the level of carbon dioxide in said closed chamber; and (d) controlling insulin infusion into blood as a consequence of the detected carbon dioxide level.
Claim 2
Dependent Claim
100 words
In a method of sensing blood glucose levels within a body of live tissue having peritoneal fluid therein for the control of insulin infusion into the body, the steps of: (a) passing glucose from the peritoneal fluid through a semipermeable membrane and into a closed chamber; (b) reacting the glucose passed into said closed chamber with a yeast suspension within the chamber to produce a level of carbon dioxide in said closed chamber; (c) detecting the level of carbon dioxide in said closed chamber; and (d) controlling insulin infusion into blood as a consequence of the detected carbon dioxide level.
Claim 3
Dependent Claim
18 words
The method defined by claim 1 wherein said reaction step is accomplished at temperature of about 106° F.
Claim 4
Dependent Claim
106 words
In a method of sensing blood glucose levels within a body of live tissue having peritoneal fluid therein for the control of insulin infusion into the body, the steps of: (a) passing glucose from the peritoneal fluid through a semipermeable membrane and into a closed chamber; (b) reacting the glucose passed into said closed chamber with a yeast suspension to form carbon dioxide and to increase the internal fluid pressure in said closed chamber; (c) detecting the rate of internal fluid pressure increase in said closed chamber; and (d) controlling insulin infusion into blood as a consequence of the detected rate of internal fluid pressure increase.
Claim 5
Dependent Claim
106 words
In a method of sensing blood glucose levels within a body of live tissue having peritoneal fluid therein for the control of insulin infusion into the body, the steps of: (a) passing glucose from the peritoneal fluid through a semipermeable membrane and into a closed chamber; (b) reacting the glucose passed into said closed chamber with a yeast suspension to form carbon dioxide and to increase the internal fluid pressure in said closed chamber; (c) detecting the rate of internal fluid pressure increase in said closed chamber; and (d) controlling insulin infusion into blood as a consequence of the detected rate of internal fluid pressure increase.
Claim 6
Dependent Claim
18 words
The method defined by claim 3 wherein said reaction is accomplished at a temperature of about 106° F.
Claim 7
Dependent Claim
87 words
Apparatus for implantation into a human body to sense blood glucose levels for the control of insulin infusion into the blood, comprising: (a) a closed chamber defined in part by a membrane that is permeable to glucose; (b) a yeast in said closed chamber in suspension in a fluid isotonic as to peritoneal fluid; and (c) carbon dioxide-responsive means in said closed chamber and connected to insulin infusion control equipment, said carbon dioxide-responsive means sensing a closed chamber condition that correlates to a level of blood glucose.
Claim 8
Dependent Claim
87 words
Apparatus for implantation into a human body to sense blood glucose levels for the control of insulin infusion into the blood, comprising: (a) a closed chamber defined in part by a membrane that is permeable to glucose; (b) a yeast in said closed chamber in suspension in a fluid isotonic as to peritoneal fluid; and (c) carbon dioxide-responsive means in said closed chamber and connected to insulin infusion control equipment, said carbon dioxide-responsive means sensing a closed chamber condition that correlates to a level of blood glucose.
Claim 9
Dependent Claim
16 words
The apparatus defined by claim 5 wherein said carbon dioxide-responsive means is a carbon dioxide-sensitive electrode.
Claim 10
Dependent Claim
17 words
The apparatus defined by claim 5 wherein said carbon dioxide-responsive means is a fluid pressure transducer means.
Claim 11
Dependent Claim
26 words
The apparatus defined by claim 7 and further comprising a rigid screen means, said screen means encasing said closed chamber and being permeable to peritoneal fluid.
Claim 12
Dependent Claim
85 words
The apparatus defined by claim 7 and further comprising a second closed chamber in part defined by a membrane, a fluid isotonic as to peritoneal fluid in said second closed chamber, second pressure transducer means in said second closed chamber means, and comparator means, said comparator means receiving the output signals of said first and second pressure transducer means and producing an output signal that regulates the insulin infusion control equipment in response to the pressure difference between said first and second pressure transducer means.
Claim 13
Dependent Claim
30 words
The apparatus defined by claim 9 and further comprising a rigid screen means, said rigid screen means encasing said first and second closed chambers and being permeable to peritoneal fluid.
Claim 14
Dependent Claim
33 words
The apparatus defined by claim 9 and further comprising heater means in said first closed chamber, said heater means heating said yeast and isotonic fluid suspension to a temperature greater than 98.6° F.
Claim 15
Dependent Claim
39 words
The apparatus defined by claim 11 and further comprising thermostatic control means, said thermostatic control means controlling said heater means and said yeast and isotonic fluid suspension in said first closed chamber to a temperature of about 106° F.
Claim 16
Dependent Claim
60 words
The apparatus defined by claim 9 and further comprising a fluid pressure rate of change detector, said fluid pressure rate of change detector receiving the output of said comparator means and producing an output signal that regulates the insulin infusion control equipment in response to the rate of change of pressure difference between said first and second pressure transducer means.
Claim 17
Dependent Claim
32 words
The apparatus defined by claim 5 and further comprising heater means in said closed chamber, said heater means heating said yeast and isotonic fluid suspension to a temperature greater than 98.6° F.
Claim 18
Dependent Claim
34 words
The apparatus defined by claim 9 and further comprising thermostatic control means, said thermostatic control means controlling said heater means and said glucose and isotonic fluid suspension to a temperature of about 106° F.
Claim 19
Dependent Claim
52 words
The apparatus defined by claim 5 and further comprising a rate of change detector means, said rate of change detector means receiving the output of said carbon dioxide-responsive means and regulating the insulin infusion control equipment in response to the change in level of carbon dioxide sensed by said carbon dioxide-responsive means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |