Patent US4780450A successfully refreshed from Google Patents.
US4780450A
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US
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Physically stable composition and method of use thereof for osseous repair
Assignee: University of Maryland, Baltimore
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Filing: 1987-07-28
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Granted: 1988-10-25
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Expires: 2007-07-28
Abstract
Abstract A composition for osseous repair which is prepared by a process comprising mixing a particulate polycrystalline calcium phosphate ceramic, a phosphophoryn calcium salt and type I collagen, preferably in a weight ratio of ceramic:calcium salt:collagen of about 775-15:3-0.1:1, to yield a solid porous composition which is effective to promote new bone formation upon introduction of the composition into osseous defects.
Inventors
- 👤 John J. Sauk
- 👤 Craig L. Van Kampen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:15
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L24/00; A61L24/04; A61L24/043; A61L24/10; A61L24/102; A61L2430/00; A61L2430/38
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
59 words
A composition for osseous repair which is prepared by a process comprising mixing a particulate polycrystalline calcium phosphate ceramic, a phosphophoryn calcium salt and type I collagen in a weight ratio of ceramic:calcium salt:collagen of about 775-15:3-0.1:1 to yield a solid porous composition which is effective to promote new bone formation upon introduction of the composition into osseous defects.
Claim 2
Dependent Claim
59 words
A composition for osseous repair which is prepared by a process comprising mixing a particulate polycrystalline calcium phosphate ceramic, a phosphophoryn calcium salt and type I collagen in a weight ratio of ceramic:calcium salt:collagen of about 775-15:3-0.1:1 to yield a solid porous composition which is effective to promote new bone formation upon introduction of the composition into osseous defects.
Claim 3
Dependent Claim
32 words
The composition of claim 1 wherein a mixture of the particulate ceramic, the phosphophoryn calcium salt and the type I collagen in water is prepared and the water is removed in vacuo.
Claim 4
Dependent Claim
12 words
The composition of claim 2 wherein the water is removed by lyophilization.
Claim 5
Dependent Claim
19 words
The composition of claim 1 wherein the particulate polycrystalline calcium phosphate ceramic comprises hydroxylapatite, beta-tricalcium phosphate or mixtures thereof.
Claim 6
Dependent Claim
12 words
The composition of claim 1 which comprises a dentinal phosphophoryn calcium salt.
Claim 7
Dependent Claim
15 words
The composition of claim 1 wherein the weight ratio of ceramic:calcium salt:collagen is about 400-20:3-0.1:1.
Claim 8
Dependent Claim
56 words
A composition for osseous repair which is prepared by a process comprising mixing particulate hydroxylapatite, a phosphophoryn calcium salt and type I collagen in a weight ratio of hydroxylapatite:phosphophoryn calcium salt:collagen of about 200-35:2.5-0.5:1, to yield a solid porous composition which is effective to promote new bone formation upon introduction of the composition into osseous defects.
Claim 9
Dependent Claim
56 words
A composition for osseous repair which is prepared by a process comprising mixing particulate hydroxylapatite, a phosphophoryn calcium salt and type I collagen in a weight ratio of hydroxylapatite:phosphophoryn calcium salt:collagen of about 200-35:2.5-0.5:1, to yield a solid porous composition which is effective to promote new bone formation upon introduction of the composition into osseous defects.
Claim 10
Dependent Claim
15 words
The composition of claim 7 wherein the hydroxylapatite particles are about 1-10 microns in diameter.
Claim 11
Dependent Claim
18 words
The composition of claim 7 wherein the weight ratio of phosphophoryn calcium salt to collagen is about 1:1.
Claim 12
Dependent Claim
28 words
A method for the repair of an osseous defect comprising introducing into said defect an amount of the composition of claim 1 effective to promote new bone formation.
Claim 13
Dependent Claim
28 words
A method for the repair of an osseous defect comprising introducing into said defect an amount of the composition of claim 7 effective to promote new bone formation.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |