US4748121A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Porous glass fibers with immobilized biochemically active material
Assignee: PPG Industries Inc
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Filing: 1984-11-30
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Granted: 1988-05-31
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Expires: 2004-11-30
Abstract
Abstract Biochemically active material is immobilized on porous silica-rich glass fibers having a diameter of about 3 to 150 microns, a length of about 0.03 inch to continuous fiber length, a mean pore diameter in the range of about 10 to 3000 angstroms, a pore volume of about 0.5 to 1.5 cc/gm and a surface area of about 10 to 600 m 2 /gm. The porous glass fibers are preferably formed from a composition containing greater than 35 up to 60 weight percent B 2 O 3 , about 1 to 10 weight percent alkali metal oxides, about 30 to 65 weight percent SiO 2 , up to about 5 weight percent ZrO 2 , and up to about 4 weight percent Al 2 O 3 . Fibers having the composition are heated to cause phase separation into a boron-rich phase and a silica-rich phase, and are then treated by water and acid leaching to produce the porous glass fibers. A biochemically active material is attached to the fibers by absorption or by covalent bonding with a linking agent.
Inventors
- 👤 Richard P. Beaver
- 👤 Ronald E. Betts
- 👤 Lin-Chang Chiang
- 👤 George V. Sanzero
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:55
CPC Classifications
C; C03; C03C; C03C11/00; C03C11/005; C03C13/00; C12; C12M; C12M21/00; C12M21/18; C12M25/00; C12M25/10; C12N; C12N11/00; C12N11/14; C12N5/00; C12N5/0068; C12N2533/00; C12N2533/10; C12N2533/12; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
263 words
Method of producing glass fibers with a discrete length having nonliving immobilized biochemically active material, comprising: a. forming sized glass fibers having a filament diameter from about 3 to about 150 microns and having a composition comprising greater than 35 up to about 60 weight percent B 2 O 3 , about 1 to about 10 weight percent alkali metal oxides, about 30 to about 65 weight percent SiO 2 , up to about 5 weight percent ZrO 2 , and up to about 4 weight percent Al 2 O 3 , b. gathering the sized fibers into one or more strands, c. collecting the one or more strands on a winder into a multilayered package, d. removing the one or more glass fiber strands from the multilayered cylindrical package, e. heat treating the glass fibers at a temperature in the range of about 400° to about 600° C. for a period of time of about 10 minutes to about 64 hours to phase separate glass into a boron-rich phase and a silica-rich phase, f. water leaching the glass fibers at an elevated temperature, g. acid leaching the glass fibers at elevated temperatures with dilute inorganic or organic acid solutions to produce porous silica-rich fibers having a pore volume of about 0.5 to 1.5 cc/gm, h. contacting the porous fibers with one or more nonliving biochemically active materials to immobilize the material in the internal surface area and on the external surface area of the glass fibers, i. maintaining the activity of the nonliving biochemically active material on and in the glass fibers.
Claim 2
Dependent Claim
263 words
Method of producing glass fibers with a discrete length having nonliving immobilized biochemically active material, comprising: a. forming sized glass fibers having a filament diameter from about 3 to about 150 microns and having a composition comprising greater than 35 up to about 60 weight percent B 2 O 3 , about 1 to about 10 weight percent alkali metal oxides, about 30 to about 65 weight percent SiO 2 , up to about 5 weight percent ZrO 2 , and up to about 4 weight percent Al 2 O 3 , b. gathering the sized fibers into one or more strands, c. collecting the one or more strands on a winder into a multilayered package, d. removing the one or more glass fiber strands from the multilayered cylindrical package, e. heat treating the glass fibers at a temperature in the range of about 400° to about 600° C. for a period of time of about 10 minutes to about 64 hours to phase separate glass into a boron-rich phase and a silica-rich phase, f. water leaching the glass fibers at an elevated temperature, g. acid leaching the glass fibers at elevated temperatures with dilute inorganic or organic acid solutions to produce porous silica-rich fibers having a pore volume of about 0.5 to 1.5 cc/gm, h. contacting the porous fibers with one or more nonliving biochemically active materials to immobilize the material in the internal surface area and on the external surface area of the glass fibers, i. maintaining the activity of the nonliving biochemically active material on and in the glass fibers.
Claim 3
Dependent Claim
49 words
Method of claim 1, which includes treating the glass fibers with an aqueous chemical treating composition before the fibers are gathered into strands, and a solid residue of the aqueous chemical treating composition is removed from the fibers before the fibers are contacted with the nonliving biochemically active material.
Claim 4
Dependent Claim
21 words
Method of claim 1, wherein the heat treated glass fibers are cooled at a rate of retard thermal cracking when leached.
Claim 5
Dependent Claim
26 words
Method of claim 1, wherein the porous glass fibers are dried to reduce the amount of moisture before being contacted with the nonliving biochemically active material.
Claim 6
Dependent Claim
49 words
Method of claim 1, wherein one or more chemical attaching agents are applied to the porous glass fibers before contacting with the nonliving biochemically active material, and the attaching agents are present in an effective amount for immobilizing the nonliving biochemically active material on the internal and external surfaces.
Claim 7
Dependent Claim
37 words
Method of claim 1, wherein the glass fibers are formed as hollow fibers having a K factor in the range of up to about 0.9, where the K factor is the ratio of internal to external diameter.
Claim 8
Dependent Claim
41 words
Method of claim 5, wherein the pores of the porous fibers have a minimum exclusion diameter such that the internal surface volume of the porous fibers allows for the linking agent and the nonliving biochemically active material to enter the pores.
Claim 9
Dependent Claim
18 words
Porous silica rich glass fibers containing immobilized nonliving biochemically active material prepared by the method of claim 1.
Claim 10
Dependent Claim
18 words
Porous silica rich glass fibers containing immobilized nonliving biochemically active material prepared by the method of claim 7.
References Cited (Backward Citations)
DE141035C
Cited
US2106744A
Cited
US2215039A
Cited
US2221709A
Cited
US2286275A
Cited
US2401841A
Cited
US2480672A
Cited
US2494259A
Cited
US2491761A
Cited
US2500092A
Cited
US2635390A
Cited
US2843461A
Cited
US3231540A
Cited
GB1066257A
Cited
US3549524A
Cited
US3556945A
Cited
US3519538A
Cited
US3666627A
Cited
US3802997A
Cited
US3650721A
Cited
US3652761A
Cited
US3669841A
Cited
US3687850A
Cited
US3841969A
Cited
US3783101A
Cited
US4025667A
Cited
US3923688A
Cited
US3923533A
Cited
US3843341A
Cited
US3804719A
Cited
US3809605A
Cited
US3850751A
Cited
US3841971A
Cited
DE2309440A1
Cited
US3892580A
Cited
US3972721A
Cited
US3972720A
Cited
US3910823A
Cited
US3930950A
Cited
US4002445A
Cited
GB1491261A
Cited
US3930951A
Cited
US3945816A
Cited
US4323650A
Cited
US4425434A
Cited
US4006059A
Cited
US4042359A
Cited
US3933589A
Cited
US4024235A
Cited
US4086074A
Cited
US4008126A
Cited
US3983000A
Cited
US4112032A
Cited
US4177038A
Cited
US4049411A
Cited
US4071339A
Cited
US4169761A
Cited
US4371612A
Cited
US4187094A
Cited
GB1557074A
Cited
JPS5622654A
Cited
JPS5622650A
Cited
US4352884A
Cited
US4363634A
Cited
US4357142A
Cited
DE3033076A1
Cited
US4397913A
Cited
JPS5874538A
Cited
US4415663A
Cited
US4415664A
Cited
US4519538A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-31 | 1991-11-30 | 1992-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-31 | 1995-11-30 | 1996-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-31 | 1999-11-30 | 2000-05-31 | $7700.00 | Window Closed / Lapsed |