Patent US4740534A successfully refreshed from Google Patents.
US4740534A
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US
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Surgical adhesive
Assignee: Sanyo Chemical Industries Ltd
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Filing: 1986-08-21
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Granted: 1988-04-26
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Expires: 2006-08-21
Abstract
Abstract Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.
Inventors
- 👤 Takehisa Matsuda
- 👤 Hiroo Iwata
- 👤 Tetsuo Itoh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:53
CPC Classifications
C; C09; C09J; C09J175/00; C09J175/04; C09J175/08; A; A61; A61L; A61L24/00; A61L24/04; A61L24/046; A61L27/00; A61L27/14; A61L27/18; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; Y; Y10; Y10S; Y10S528/00; Y10S528/904
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
61 words
A surgical adhesive, which comprises: (A) at least one NCO-terminated hydrophilic urethane prepolymer, derived from at least one organic polyisocyanate and a polyol component comprising at least one hydrophilic polyether polyol having an oxyethylene content of at least 30%; and (B) at least one unsaturated cyano compound containing a cyano group attached to a carbon atom constituting the polymerizable double bond.
Claim 2
Dependent Claim
61 words
A surgical adhesive, which comprises: (A) at least one NCO-terminated hydrophilic urethane prepolymer, derived from at least one organic polyisocyanate and a polyol component comprising at least one hydrophilic polyether polyol having an oxyethylene content of at least 30%; and (B) at least one unsaturated cyano compound containing a cyano group attached to a carbon atom constituting the polymerizable double bond.
Claim 3
Dependent Claim
15 words
The adhesive of claim 1, wherein said prepolymer has an isocyanate-content of 1-10% by weight.
Claim 4
Dependent Claim
17 words
The adhesive of claim 1, wherein said polyol component has an oxyethylene content of at least 30%.
Claim 5
Dependent Claim
22 words
The adhesive of claim 1, wherein said polyol component has an equivalent weight (average) of 100-5,000 and a functionality (average) of 2-8.
Claim 6
Dependent Claim
70 words
The adhesive of claim 1, wherein said polyisocyanate is at least one selected from the group consisting of aromatic polyisocyanates containing 6-20 carbon atoms, aliphatic polyisocyanates containing 2-18 carbon atoms, alicyclic polyisocyanates containing 4-15 carbon atoms, araliphatic polyisocyanates containing 8-15 carbon atoms, except carbon atoms in NCO groups, and modified polyisocyanates of these polyisocyanates containing one or more of urethane, carbodiimide, allophanate, urea, biuret, urethdione, urethimine, isocyanurate and oxazolidone groups.
Claim 7
Dependent Claim
21 words
The adhesive of claim 1, wherein said polyisocyanate is p-phenylene diisocyanate, or a combination thereof with one or more other polyisocyanates.
Claim 8
Dependent Claim
41 words
The adhesive of claim 1, wherein said hydrophilic polyether polyol is at least one adduct of ethylene oxide or a combination thereof with one or more other alkylene oxides to at least one compound containing two or more active hydrogen atoms.
Claim 9
Dependent Claim
35 words
The adhesive of claim 7, wherein said compound containing two or more active hydrogen atoms is at least one selected from the group consisting of polyhydric alcohols, polyhydric phenols, amines, polycarboxylic acids and phosphorous acids.
Claim 10
Dependent Claim
27 words
The adhesive of claim 1, wherein said hydrophilic polyether polyol is at least one selected from the group consisting of polyoxyethylene polyols, polyoxyethylene/oxypropylene polyols and polyoxyethylene/oxybutylene polyols.
Claim 11
Dependent Claim
37 words
The adhesive of claim 1, wherein said said polyol component comprises said hydrophilic polyether polyol and at least one other polyol selected from the group consisting of low molecular weight polyols, hydrophobic polyether polyols and polyester polyols.
Claim 12
Dependent Claim
27 words
The adhesive of claim 1, wherein said prepolymer is obtained by reacting said polyisocyanate with said polyol component in such an amount providing NCO/OH ratio of 1.5-5.0.
Claim 13
Dependent Claim
21 words
The adhesive of claim 1, which comprises 20-90% by weight of said prepolymer and 10-80% by weight of said cyano compound.
Claim 14
Dependent Claim
31 words
The adhesive of claim 1, wherein said cyano compound is at least one compound selected from the group consisting of cyanoacrylic acid, cyanomethacrylic acid, cyanoacrylates, cyanomethacrylates, acrylonitrile, methacrylonitrile, cyanoacrylonitrile and cyanomethacrylonitrile.
Claim 15
Dependent Claim
28 words
The adhesive of claim 1, wherein said cyano compound is at least one cyanoacrylic ester selected from the group consisting of methyl cyanoacrylate, ethyl cyanoacrylate nd iso-butyl cyanoacrylate.
Claim 16
Dependent Claim
37 words
The adhesive of claim 1, which contains up to 20% by weight of at least one additive selected from the group consisting of carbon black, metal oxides, silicates, acrylic resin powders, ceramic powders, softening agents, and stabilizers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |