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US4740382A
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Antibiotic bonded prosthesis and process for producing same
Assignee: MEDICINE & MENTISTRY, University of
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Filing: 1984-07-23
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Granted: 1988-04-26
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Expires: 2004-07-23
Abstract
Abstract There is disclosed an improved prosthesis coated, respectively, with a cationic surfactant, an antibiotic compound and treated with an cationic exchange compound, to remove un-antibiotic bound cationic surfactant.
Inventors
- 👤 Ralph S. Greco
- 👤 Richard Harvey
- 👤 Stanley Z. Trooskin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:20
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/60; A61L2300/606; A61L2300/80; A61L2300/802; Y; Y10; Y10S; Y10S273/00; Y10S273/04; Y10S273/09; Y10T; Y10T428/00; Y10T428/31504; Y10T428/3154; Y10T428/31544
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
70 words
A prosthesis for use in in vivo surgery having a coating, respectively, of a cationic surfactant and an antibiotic compound offering a charge opposite to that of said surfactant and bound to said surfactant, wherein said coating is discontinuous as to areas where said cationic surfactant lacks antibiotic bound thereto, said cationic surfactant having been removed in said areas the application thereto and removal of an immobilizing cationic exchange compound.
Claim 2
Dependent Claim
70 words
A prosthesis for use in in vivo surgery having a coating, respectively, of a cationic surfactant and an antibiotic compound offering a charge opposite to that of said surfactant and bound to said surfactant, wherein said coating is discontinuous as to areas where said cationic surfactant lacks antibiotic bound thereto, said cationic surfactant having been removed in said areas the application thereto and removal of an immobilizing cationic exchange compound.
Claim 3
Dependent Claim
27 words
The prosthesis as defined in claim 1 wherein said antibiotic compound is selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, a cephalosporin and a cefoxitin.
Claim 4
Dependent Claim
15 words
The prosthesis as defined in claim 1 wherein said cationic surfactant is tridodecylmethyl ammonium chloride.
Claim 5
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said cationic exchange compound is Sheparose-CM.
Claim 6
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said prosthesis is a vascular graft.
Claim 7
Independent Claim
76 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with a cationic surfactant to coat said prosthesis with said cationic surfactant; (b) contacting said prosthesis of step (a) with a solution of an antibiotic compound offering a charge opposite to that of said surfactant; and (c) contacting said prosthesis of step (b) with an cationic exchange compound to remove cationic surfactant not bound to said antibiotic compound.
Claim 8
Independent Claim
76 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with a cationic surfactant to coat said prosthesis with said cationic surfactant; (b) contacting said prosthesis of step (a) with a solution of an antibiotic compound offering a charge opposite to that of said surfactant; and (c) contacting said prosthesis of step (b) with an cationic exchange compound to remove cationic surfactant not bound to said antibiotic compound.
Claim 9
Dependent Claim
24 words
The method as defined in claim 6 wherein the prosthesis of step (a) is washed to remove excess cationic surfactant prior to step (b).
Claim 10
Independent Claim
26 words
The method as defined in claims 6 or 7 wherein said prosthesis of step (b) is washed to remove unbound antibiotic compound prior to step (c).
Claim 11
Dependent Claim
23 words
The method as defined in claim 6 wherein step (a) is effected for a period of time of from 5 to 120 minutes.
Claim 12
Dependent Claim
19 words
The method as defined in claim 9 wherein step (a) is effected preferably for a period of 30 minutes.
Claim 13
Dependent Claim
21 words
The method as defined in claim 6 wherein step (a) is effected at a temperature of from 0° to 55° C.
Claim 14
Dependent Claim
16 words
The method as defined in claim 11 wherein step (a) is effected preferably at ambient temperature.
Claim 15
Dependent Claim
23 words
The method as defined in claim 6 wherein step (b) is effected for a period of time of from 5 to 120 minutes.
Claim 16
Dependent Claim
17 words
The method as defined in claim 13 wherein step (b) is effected preferably for about 30 minutes.
Claim 17
Dependent Claim
21 words
The method as defined in claim 6 wherein step (b) is effected at a temperature of from 0° to 35° C.
Claim 18
Dependent Claim
19 words
The method as defined in claim 15 wherein step (b) is effected preferably at a temperature of 25° C.
Claim 19
Dependent Claim
23 words
The method as defined in claim 6 wherein step (c) is effected for a period of time of from 6 to 72 hours.
Claim 20
Dependent Claim
21 words
The method as defined in claim 17 wherein step (c) is effected preferably for a period of time of 20 hours.
Claim 21
Dependent Claim
21 words
The method as defined in claim 6 wherein step (c) is effected at a temperature of from 0° to 35° C.
Claim 22
Dependent Claim
20 words
The method as defined in claim 19 wherein the step (c) is effected preferably at a temperature of 25° C.
Claim 23
Dependent Claim
14 words
The method as defined in claim 6 wherein said cationic exchange compound is particulate.
Claim 24
Dependent Claim
23 words
The method as defined in claim 21 wherein said particulate cationic surfactant has a particle size range of from 2 to 40 microns.
Claim 25
Dependent Claim
15 words
The method as defined in claim 22 wherein said particle size is about 2 microns.
Claim 26
Dependent Claim
15 words
The method as defined in claim 6 wherein said cationic surfactant is tridodecylmethyl ammonium chloride.
Claim 27
Dependent Claim
27 words
The method as defined in claim 6 wherein said antibiotic compound is selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, a cephalosporin and a cefoxitin.
Claim 28
Dependent Claim
22 words
The method as defined in claim 6 wherein said cationic exchange compound is selected from the group consisting of Sepharose-CM and SP-Sephadex.
Claim 29
Dependent Claim
14 words
The method as defined in claim 26 wherein said cationic exchange compound is Sepharose-CM.
References Cited (Backward Citations)
US3651043A
Cited
US4442133A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-04-26 | 1991-10-26 | 1992-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-04-26 | 1995-10-26 | 1996-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-04-26 | 1999-10-26 | 2000-04-26 | $7700.00 | Window Closed / Lapsed |