Patent US4690130A successfully refreshed from Google Patents.
US4690130A
Expired / Lapsed
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Electromagnetic therapy control system
Assignee: MAGNACON Inc A CORP OF
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Filing: 1985-12-19
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Granted: 1987-09-01
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Expires: 2005-12-19
Abstract
Abstract Chemotherapy may be selectively localized to a tumor located at a point well within the human body by physically associating the chemotherapy agent with magnetic material having a Curie point temperature slightly above the normal temperature of the human body. Both materials may be associated with protein microspheres such as human serum albumin. By applying a magnetic field to the tumor location and then applying electromagnetic radiation to heat the Curie point magnetic material (so that it loses its magnetic properties), away from the tumor site, but not at the tumor site, the unheated magnetic material and the physically associated chemotherapy agent will be localized at the tumor. Radioactive material may also be employed to facilitate imaging of the concentration of the microspheres and for radiation treatment.
Inventors
- 👤 Stuart G. Mirell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; A61K41/00; A61K41/0052; A61N; A61N1/00; A61N1/40; A61N1/403; A61N1/406; A61F; A61F7/00; A61F2007/009
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
136 words
A method for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising: applying a steady or low frequency magnetic field to the patient to include the treatment zone; supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.
Claim 2
Independent Claim
136 words
A method for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising: applying a steady or low frequency magnetic field to the patient to include the treatment zone; supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.
Claim 3
Dependent Claim
36 words
A method as defined in claim 1 including the step of adding a radiation emitting material to said microspheres and determining the concentration of said microspheres at different locations within said patient from the output radiation.
Claim 4
Dependent Claim
41 words
A method as defined in claim 2 including the additional step of modifying the application of the magnetic field and the high frequency electromagnetic field to increase the concentration of microspheres in the treatment area in accordance with the concentration determination.
Claim 5
Dependent Claim
54 words
A method as defined in claim 1 wherein the application of a high frequency field includes the step of directing high frequency electromagnetic field energy having the same frequency from two different radiating sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the treatment zone.
Claim 6
Dependent Claim
76 words
A method as defined in claim 1 wherein the magnetic field is applied to the patient from a predetermined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the magnetic material toward the adjacent surface of the body but not to heat the magnetic material in the treatment area beyond the Curie point temperature.
Claim 7
Dependent Claim
53 words
A method as defined in claim 1 wherein the applying of a high frequency electromagnetic field provides a sharper delineation of microsphere concentration at the boundaries of the treatment zone by the cancellation of magnetic field components adjacent to said treatment zone n conjunction with the magnetic materials having an electrically conductive composition.
Claim 8
Dependent Claim
22 words
A system as defined in claim 6 wherein said objects including Curie point material are microspheres which also contain a therapeutic agent.
Claim 9
Independent Claim
142 words
A system for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising: means for applying a steady or low frequency magnetic field to the patient to include the treatment zone; means for supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically, bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and means for applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.
Claim 10
Independent Claim
142 words
A system for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising: means for applying a steady or low frequency magnetic field to the patient to include the treatment zone; means for supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically, bodily compatible magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and means for applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.
Claim 11
Dependent Claim
16 words
A system as defined in claim 8 wherein radiation emitting material is included in said microspheres.
Claim 12
Dependent Claim
20 words
A system as defined in claim 9 including means sensitive to said radiation for determining the location of said microspheres.
Claim 13
Dependent Claim
24 words
A system as defined in claim 8 wherein means for emitting gamma rays and means for emitting beta rays are included in said microspheres.
Claim 14
Dependent Claim
54 words
A system as defined in claim 8 wherein the means for applying a high frequency field includes means for directing high frequency electromagnetic field energy having the same frequency from two different radiating sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the treatment zone.
Claim 15
Dependent Claim
79 words
A system as defined in claim 8 wherein the magnetic field is applied to the patient from a predetermined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the magnetic material toward the adjacent surface of the body but at an intensity insufficient to heat the magnetic material in the treatment area beyond the Curie point temperature.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-31 | 1991-03-02 | 1991-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-31 | 1995-03-02 | 1995-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-31 | 1999-03-02 | 1999-09-01 | $7700.00 | Window Closed / Lapsed |