US4590922A
Expired / Lapsed
US
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Use of ferromagnetic, paramagnetic and diamagnetic particles in the treatment of infectious diseases
Assignee: GORDON DAVID SKOKIE ILLINOIS
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Filing: 1983-08-19
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Granted: 1986-05-27
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Expires: 2003-08-19
Abstract
Abstract This invention provides a method of treatment of infectious disease organisms comprising introducing minute particles into the interior of infectious cells. These particles possess ferromagnetic, paramagnetic or diamagnetic properties. After being localized intracellularly, these particles are inductively heated by application of an alternating electromagnetic field. The inductive heating is continued for a period of time sufficient to bring about an intracellular temperature rise to a minimum necessary to kill the infectious organism.
Inventors
- 👤 Robert T. Gordon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:20
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/40; A61N1/403; A61N1/406
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
59 words
A method of treatment of infectious disease organisms comprising: providing to said organism minute, inductively heatable, intracellularly-localizable particles of a size less than 1 micron, and inductively heating said particles by the application of an alternating electromagnetic field for a period of time sufficient to effect a rise in intracellular temperature to a minimum necessary to kill said organism.
Claim 2
Independent Claim
59 words
A method of treatment of infectious disease organisms comprising: providing to said organism minute, inductively heatable, intracellularly-localizable particles of a size less than 1 micron, and inductively heating said particles by the application of an alternating electromagnetic field for a period of time sufficient to effect a rise in intracellular temperature to a minimum necessary to kill said organism.
Claim 3
Dependent Claim
21 words
The method according to claim 1 wherein said infectious organisms are selected from the group comprising viruses, bacteria, fungi and protozoa.
Claim 4
Dependent Claim
27 words
The method according to claim 2 wherein said infectious organisms comprise Salmonella, Klebsiella, Escherichia, Clostridium, Mycobacterium, Pseudomonas, Peptostreptococcus, Phycomyces, Candida, Ustilago, Entamoeba, Trypanosoma, Leishmania and RNA viruses.
Claim 5
Dependent Claim
27 words
The method according to claim 1 wherein said particles are selected from the group comprising ferromagnetic, paramagnetic and diamagnetic elements, inorganic compounds, organic compounds and combinations thereof.
Claim 6
Dependent Claim
157 words
The method according to claim 4 wherein said particles are selected from the group comprising (a) inorganic metals and compounds comprising dysprosium, erbium, europium, gallium, holmium, samarium, terbium, thulium, ytterbium, or yttrium, dysprosium sulfate, erbium sulfate, europium oxide, europium sulfate, holmium oxide, samarium sulfate, terbium sulfate, thulium oxide, ytterbium sulfide, yttrium oxide, yttrium sulfate, yttrium ferrioxide (Y 3 Fe 5 O 12 ) and yttrium aluminum oxide (Y 3 Al 5 O 12 ); (b) metal containing organic compounds comprising dextran metal complexes wherein said metal is selected from the group comprising cobalt, zinc, chromium, nickel, platinum, manganese and rare earth metals dysprosium, erbium, gallium, holmium, samarium, terbium, thulium, ytterbium, yttrium and iron; (c) iron transport and chelating compounds comprising ferric ammonium citrate, enterochelin, hydroxamates, phenolates, ferrichromes, desferri-ferrichromes, ferritin, ferric mycobactins and iron sulfur proteins; and (d) porphyrins comprising etioporphyrins, mesoporphyrins, uroporphyrins, coproporphyrins, protoporphyrins and dicarboxylic acid containing porphyrins such as tetraphenylporphyrin sulfonate, hematoporphyrins, chlorophylls and cytochromes.
Claim 7
Dependent Claim
14 words
The method according to claim 5 wherein said iron dextran complexes comprise FeOOH-dextran complexes.
Claim 8
Dependent Claim
14 words
The method according to claim 5 wherein said iron-sulfur proteins comprise ferredoxin and rubredoxin.
Claim 9
Dependent Claim
18 words
The method according to claim 5 wherein said dicarboxylic acid porphyrins comprise tetraphenylporphyrin sulfonate, hematoporphyrins, chlorophylls and cytochromes.
Claim 10
Independent Claim
86 words
A method of treatment of infectious disease organisms within a living host without substantially damaging normal host cells comprising: introducing into the host minute, intracellularly-localizable particles capable of being inductively heated and of a size less than 1 micron whereby said minute particles are selectively absorbed into the infectious cells; and inductively heating said particles by exposing the host to an alternating electromagnetic field for a period of time sufficient to attain a rise in intracellular temperature to a minimum necessary to kill the infectious cells.
Claim 11
Independent Claim
86 words
A method of treatment of infectious disease organisms within a living host without substantially damaging normal host cells comprising: introducing into the host minute, intracellularly-localizable particles capable of being inductively heated and of a size less than 1 micron whereby said minute particles are selectively absorbed into the infectious cells; and inductively heating said particles by exposing the host to an alternating electromagnetic field for a period of time sufficient to attain a rise in intracellular temperature to a minimum necessary to kill the infectious cells.
Claim 12
Dependent Claim
16 words
The method according to claim 9 wherein said particles may be administered either orally or parenterally.
Claim 13
Dependent Claim
22 words
The method according to claim 10 wherein said parenteral administration comprises introduction of particles intravenously, intramuscularly, intraperitoneally, topically, or in suppository form.
Claim 14
Dependent Claim
20 words
The method according to claim 9 wherein infectious organisms are selected from the group comprising viruses bacteria, fungi and protozoa.
Claim 15
Dependent Claim
32 words
The method according to claim 12 wherein said infectious organisms are selected from the group comprising Salmonella, Klebsiella, Escherichia, Clostridium, Mycobacterium, Pseudomonas, Peptostreptococcus, Phycomyces, Candida, Ustilago, Entamoeba, Trypanosoma, Leishmania and RNA viruses.
Claim 16
Dependent Claim
27 words
The method according to claim 9 wherein said particles are selected from the group comprising ferromagnetic, paramagnetic, or diamagnetic elements, inorganic compounds, organic compounds and combinations thereof.
Claim 17
Dependent Claim
45 words
The method according to claim 9 wherein particles are selected from the group comprising: (a) ferric hydroxide, and iron dextrans, (b) iron and iron chelating compounds comprising ferric ammonium citrate, enterochelin, hydroxamates, phenolates, desferri-ferrichromes, ferritin, ferric mycobactins, and iron sulfur proteins, (c) protoporphyrin containing molecules.
Claim 18
Dependent Claim
15 words
The method according to claim 15 wherein said iron sulfur proteins comprise ferredoxin and rubredoxin.
Claim 19
Dependent Claim
13 words
The method according to claim 15 wherein said protoporphyrin containing molecules comprise cytochromes.
Claim 20
Independent Claim
91 words
A method of treatment of infectious disease organisms within a living host without substantially damaging normal host cells comprising: introducing into the host infectious organism-specific, intracellularly localizable particles capable of being inductively heated and of a size less than 1 micron; selectively concentrating said particles within the infectious organism; and differentially killing the infectious organism by exposing the host to an alternating electromagnetic field, thereby inductively heating said particles for a period of time sufficient to attain a rise in intracellular temperature to a minimum necessary to kill the infectious cells.
Claim 21
Independent Claim
91 words
A method of treatment of infectious disease organisms within a living host without substantially damaging normal host cells comprising: introducing into the host infectious organism-specific, intracellularly localizable particles capable of being inductively heated and of a size less than 1 micron; selectively concentrating said particles within the infectious organism; and differentially killing the infectious organism by exposing the host to an alternating electromagnetic field, thereby inductively heating said particles for a period of time sufficient to attain a rise in intracellular temperature to a minimum necessary to kill the infectious cells.
Claim 22
Independent Claim
51 words
A method of treatment of infectious disease organisms without substantially damaging normal cells comprising: inductively heating particles endogenous to said organism by application of an alternating electromagnetic field for a period of time sufficient to bring about a rise in intracellular temperature to a minimum necessary to kill the infectious organism.
Claim 23
Independent Claim
51 words
A method of treatment of infectious disease organisms without substantially damaging normal cells comprising: inductively heating particles endogenous to said organism by application of an alternating electromagnetic field for a period of time sufficient to bring about a rise in intracellular temperature to a minimum necessary to kill the infectious organism.
Claim 24
Dependent Claim
20 words
The method according to claim 19 wherein said organisms are selected from the group comprising viruses, bacteria, fungi and protozoa.
Claim 25
Independent Claim
30 words
The method according to 20 wherein said organisms are selected from the group comprising Salmonella, Klebsiella, Escherichia, Clostridium, Mycobacterium, Pseudomonas, Peptostreptococcus, Phycomyces, Candida, Ustilago, Entamoeba, Trypanosoma, Leishmania and RNA viruses.
Claim 26
Independent Claim
30 words
The method according to 20 wherein said organisms are selected from the group comprising Salmonella, Klebsiella, Escherichia, Clostridium, Mycobacterium, Pseudomonas, Peptostreptococcus, Phycomyces, Candida, Ustilago, Entamoeba, Trypanosoma, Leishmania and RNA viruses.
Claim 27
Dependent Claim
27 words
The method according to claim 20 wherein said particles are selected from the group comprising ferromagnetic, paramagnetic or diamagnetic elements, inorganic compounds, organic compounds or combinations thereof.
Claim 28
Dependent Claim
21 words
The method according to claim 20 in which said particles are selected from the group comprising ferritins, ferrodoxins, rubredoxins and cytochromes.
Claim 29
Independent Claim
67 words
A method of surface sterilization of inanimate objects having contaminating organisms comprising: placing said object in a particle containing solution, allowing sufficient time for absorption of said particles by contaminating organisms, inductively heating said particles by application to the object of an alternating electromagnetic field for a period of time sufficient to attain a rise in intracellular temperature to a level necessary to kill the contaminating organisms.
Claim 30
Independent Claim
67 words
A method of surface sterilization of inanimate objects having contaminating organisms comprising: placing said object in a particle containing solution, allowing sufficient time for absorption of said particles by contaminating organisms, inductively heating said particles by application to the object of an alternating electromagnetic field for a period of time sufficient to attain a rise in intracellular temperature to a level necessary to kill the contaminating organisms.
Claim 31
Dependent Claim
27 words
The method according to claim 24 wherein said particles are selected from the group comprising ferromagnetic, paramagnetic and diamagnetic elements, inorganic compounds, organic compounds and combinations thereof.
Claim 32
Dependent Claim
21 words
The method according to claim 24 wherein said contaminating organism is selected from the group comprising viruses, bacteria, fungi and protozoa.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-26 | 1989-11-25 | 1990-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-26 | 1993-11-25 | 1994-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-26 | 1997-11-25 | 1998-05-27 | $7700.00 | Window Closed / Lapsed |