Patent US4678468A successfully refreshed from Google Patents.
US4678468A
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US
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Cardiovascular prosthesis
Assignee: Bio Medical Co Ltd
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Filing: 1985-08-05
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Granted: 1987-07-07
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Expires: 2005-08-05
Abstract
Abstract In a cardiovascular prosthesis, at least a part of blood contact surface of the prosthesis is formed by polymer composition comprising water soluble polymer such as heparin and crosslinked polysiloxane, at least a part of the water soluble polymer being entangled or intertwisted into polysiloxane networks.
Inventors
- 👤 Toshiki Hiroyoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:15
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
44 words
A cardiovascular prosthesis, wherein at least a part of its blood contact surface is formed by a polymer composition comprising a water soluble polymer and a crosslinked polysiloxane, at least a part of said water soluble polymer being entangled or intertwisted into polysiloxane networks.
Claim 2
Dependent Claim
44 words
A cardiovascular prosthesis, wherein at least a part of its blood contact surface is formed by a polymer composition comprising a water soluble polymer and a crosslinked polysiloxane, at least a part of said water soluble polymer being entangled or intertwisted into polysiloxane networks.
Claim 3
Dependent Claim
44 words
A cardiovascular prosthesis according to claim 1, wherein said water soluble polymer includes heparin as an essential ingredient and at least a part of heparin as well as the other water soluble polymer component or components is entangled or intertwisted into said polysiloxane networks.
Claim 4
Dependent Claim
16 words
A cardiovascular prosthesis according to claim 2, wherein said water soluble polymer further includes polyvinyl alcohol.
Claim 5
Dependent Claim
64 words
A cardiovascular prosthesis according to claim 1, wherein said water soluble polymer comprises at least one selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene oxide-propylene oxide copolymer, polyvinyl pyrrolidone, soluble collagen, gelatin, polyacrylic acid, polymethacrylic acid, polyhydroxy-ethyl methacrylic acid, polyhydroxy ethylacrylic acid, polyacrylamide, polymethacrylamide, 2-acrylamide-2-methylpropane sulfonic acid, soluble starch, methyl cellulose, polysaccharide hyaluronic acid, chondroitin sulfate, oxidized starch and dialdehyde starch.
Claim 6
Independent Claim
37 words
A method of producing a cardiovascular prosthesis, wherein a base body of said prosthesis is treated with a solution comprising a water soluble polymer and a silico-component which has a capability of inducing polymerization to crosslinked polysiloxane.
Claim 7
Independent Claim
37 words
A method of producing a cardiovascular prosthesis, wherein a base body of said prosthesis is treated with a solution comprising a water soluble polymer and a silico-component which has a capability of inducing polymerization to crosslinked polysiloxane.
Claim 8
Dependent Claim
22 words
A method of producing a cardiovascular prosthesis according to claim 5, wherein said water soluble polymer includes heparin as an essential ingredient.
Claim 9
Dependent Claim
20 words
A method of producing a cardiovascular prosthesis according to claim 6, wherein said water soluble polymer further includes polyvinyl alcohol.
Claim 10
Dependent Claim
46 words
A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of the group formulated as: R.sub.n --Si--R'.sub.n-n where R is a hydrocarbon radical, R' is one of alkoxy, acyloxy, halogen and amino radical, and n is 0, 1 or 2.
Claim 11
Dependent Claim
68 words
A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of the group formulated as: R.sub.n R'.sub.3-n Si--O--SiR.sub.m R".sub.3-m where n and m are selected from 1, 2 and 3, respectively, n+m=0, 1, 2, 3 or 4, R is a hydrocarbon radical, and R' and R" are selected from the group capable of converting to a functional group inducing polymerization by activation.
Claim 12
Dependent Claim
24 words
A method of producing a cardiovascular prosthesis according to claim 5, wherein said silico-component is one of silane coupling agents for room temperature vulcanization.
Claim 13
Dependent Claim
69 words
A method of producing a cardiovascular prosthesis according to claim 5, wherein said water soluble polymer is at least one selected from the group consisting of polyethylene glycol, polypropylene glycol, ethylene oxide-propyleneoxide copolymer, polyvinyl pyrrolidone, soluble collagen, gelatin, polyacrylic acid, polymethacrylic acid, polyhydroxy ethyl methacrylic acid, polyhydroxy ethyl acrylic acid, polyacrylamide, polymethacrylamide, 2-acrylamide-2-methyl-propane sulfonic acid, soluble starch, methyl cellulose, polysaccharide, hyaluronic acid, chondroitin sulfate, oxidized starch or dialdehyde starch.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-06 | 1991-01-05 | 1991-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-06 | 1995-01-05 | 1995-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-06 | 1999-01-05 | 1999-07-07 | $7700.00 | Window Closed / Lapsed |