Polyparaffinsiloxane shaped article for use in biomedical applications

Claim 2

A fillerless, hydrolytically stable, biologically inert, transparent, oxygen transporting, polymeric, shaped article for use in biomedical applications comprising polymerizing a poly(organoparaffinsiloxane) monomer represented by the following formula: ##STR28## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR29## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR30## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater, forming a polymer in a crosslinked network.

Claim 3

The shaped article for use in biomedical applications according to claim 1 wherein A is selected from the group consisting of 2-cyanoacryloxy, acrylonitryl, acrylamido, acryloxy, methacryloxy, styryl, N-vinyl-2-pyrrolidinone-3-yl, N-vinyl-2-pyrrolidinone-4-yl and N-vinyl-2-pyrrolidinone-5-yl and R is an alkylene radical and R 1 , R 2 , R 3 and R 4 are alkyl radicals having from 1 to 10 carbon atoms.

Claim 4

The shaped article for use in biomedical applications according to claim 2 wherein m is a number of from 1 to about 200.

Claim 5

The shaped article for use in biomedical applications according to claim 3 wherein m is a number from 1 to about 50.

Claim 6

The shaped article for use in biomedical applications according to claim 4 wherein m is a number from 1 to about 25.

Claim 7

The shaped article for use in biomedical applications according to claim 1 wherein x is a number from 2 to 3.

Claim 8

The shaped article for use in biomedical applications according to claim 1 is a contact lens.

Claim 9

A fillerless, hydrolytically stable, biologically inert, transparent, oxygen transporting, polymeric shaped article for use in biomedical applications comprising a poly (organoparaffinsiloxane) monomer represented by the following formula: ##STR31## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR32## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR33## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater, copolymerized with one or more monomers selected from the group consisting of a lower ester of acrylic and methacrylic acid, styryls, and N-vinyl pyrrolidinone forming a copolymer in a crosslinked network.

Claim 10

A fillerless, hydrolytically stable, biologically inert, transparent, oxygen transporting, polymeric shaped article for use in biomedical applications comprising a poly (organoparaffinsiloxane) monomer represented by the following formula: ##STR31## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR32## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR33## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater, copolymerized with one or more monomers selected from the group consisting of a lower ester of acrylic and methacrylic acid, styryls, and N-vinyl pyrrolidinone forming a copolymer in a crosslinked network.

Claim 11

The shaped article for use in biomedical applications according to claim 8 wherein the monomers are selected from the group consisting of tertiary butyl styrene, propyl styrene, styrene and N-vinyl pyrrolidone.

Claim 12

The shaped article for use in biomedical applications according to claim 8 wherein the monomer is selected from the group consisting of allyl methacrylate, butoxyethylmethacrylate, cyclohexyl methacrylate, ethyl methacrylate, methylmethacrylate, ethyl hexyl acrylate, n-butyl acrylate, butyl acrylate, N-vinyl pyrrolidinone, isobornyl acrylate, menthyl acrylate, adamantanyl acrylate and isopinocamphyl acrylate.

Claim 13

The shaped article for use in biomedical applications according to claim 8 wherein x is a number from 2 to 3.

Claim 14

The shaped article for use in biomedical applications according to claim 8 is a contact lens.

Claim 15

A fillerless, flexible, hydrolytically stable, biologically inert, transparent, resilient, soft, oxygen transporting, polymeric, shaped article for use in biomedical applications comprising polymerizing a poly(organosiloxane) monomer represented by the following formula: ##STR34## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR35## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR36## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater forming a polymer in a crosslinked network.

Claim 16

A fillerless, flexible, hydrolytically stable, biologically inert, transparent, resilient, soft, oxygen transporting, polymeric, shaped article for use in biomedical applications comprising polymerizing a poly(organosiloxane) monomer represented by the following formula: ##STR34## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR35## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR36## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater forming a polymer in a crosslinked network.

Claim 17

The shaped article for use in biomedical applications according to claim 13 wherein m is a number of from about 50 to about 800.

Claim 18

The shaped article for use in biomedical applications according to claim 14 wherein A is selected from the group consisting of 2-cyanoacryloxy, acrylonitryl, acrylamido, acryloxy, methacryloxy, styryl, N-vinyl-2-pyrrolidinone-3-yl, N-vinyl-2-pyrrolidinone-4-yl and N-vinyl-2-pyrrolidinone-5-yl and R is an alkylene radical and R 1 , R 2 , R 3 and R 4 is an alkyl radical having from 1 to 10 carbon atoms.

Claim 19

The shaped article for use in biomedical applications according to claim 15 wherein the alkylene radical has from about 1 to about 4 carbon atoms.

Claim 20

The shaped article for use in biomedical applications according to claim 16 wherein the alkylene radical has from about 3 to about 4 carbon atoms.

Claim 21

The shaped article for use in biomedical applications according to claim 17 wherein R 1 , R 2 , R 3 and R 4 are selected from the group consisting of a methyl radical and a phenyl radical.

Claim 22

The shaped article for use in biomedical applications according to claim 18 wherein R 1 , R 2 , R 3 , and R 4 are methyl radicals.

Claim 23

The contact lens according to claim 19 wherein R 5 and R 6 are selected from the group consisting of hydrogen and methyl.

Claim 24

The shaped article for use in biomedical applications according to claim 13 wherein x is a number from 2 to 3.

Claim 25

The shaped article for use in biomedical applications according to claim 13 is a contact lens.

Claim 26

A fillerless, flexible, hydrolytically stable, biologically inert, transparent, resilient, soft, oxygen transporting, polymeric, shaped article for use in biomedical applications comprising a poly(organosiloxane) monomer represented by the following formula: ##STR37## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR38## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR39## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater copolymerized with one or more monomers selected from the group consisting of a lower ester of acrylic and methacrylic acid, styryls, and N-vinyl pyrrolidone forming a polymer in a crosslinked network.

Claim 27

A fillerless, flexible, hydrolytically stable, biologically inert, transparent, resilient, soft, oxygen transporting, polymeric, shaped article for use in biomedical applications comprising a poly(organosiloxane) monomer represented by the following formula: ##STR37## wherein A is an activated unsaturated group; R is a divalent hydrocarbon radical having from 1 to about 22 carbon atoms; R 1 , R 2 , R 3 and R 4 can be the same or different and are selected from the group consisting of a monovalent hydrocarbon radical having from 1 to about 12 carbon atoms and a halogen substituted monovalent hydrocarbon radical having from 1 to about 12 carbon atoms; R 5 and R 6 can be the same or different and are selected from the group consisting of hydrogen, a hydrocarbon radical containing from 1 to about 12 carbon atoms, a carboxylic acid group, a carboxylic acid ester group represented by the formula ##STR38## wherein R 7 is selected from the group consisting of a hydrocarbon group containing from 1 to about 12 carbon atoms and a carboxylic acid amide represented by the formula ##STR39## wherein R 8 and R 9 can be the same or different and each is selected from the group consisting of hydrogen and a hydrocarbon group containing from 1 to about 12 carbon atoms; x is 2 or greater and m is 1 or greater copolymerized with one or more monomers selected from the group consisting of a lower ester of acrylic and methacrylic acid, styryls, and N-vinyl pyrrolidone forming a polymer in a crosslinked network.

Claim 28

The shaped article for use in biomedical applications according to claim 23 wherein the monomers are selected from the group consisting of tertiary butyl styrene, propyl styrene, styrene and N-vinyl pyrrolidone.

Claim 29

The shaped article for use in biomedical applications according to claim 23 wherein the monomer is selected from the group consisting of allyl methacrylate, butoxyethylmethacrylate, ethyl hexyl acrylate, n-butyl acrylate, butyl acrylate and N-vinyl pyrrolidone, isobornyl acrylate, menthyl acrylate, adamantanyl acrylate and isopinocamphyl acrylate.

Claim 30

The shaped article for use in biomedical applications according to claim 25 wherein x is a number from 2 to 3.

Claim 31

The shaped article for use in biomedical applications according to claim 26 is a contact lens.