Patent US4592920A successfully refreshed from Google Patents.
US4592920A
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Method for the production of an antimicrobial catheter
Assignee: Allegiance Corp
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Filing: 1983-05-20
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Granted: 1986-06-03
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Expires: 2003-05-20
Abstract
Abstract A method for the production of antimicrobial catheters includes the steps of comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter. The comminuted antimicrobial metal compound is suspended in a suspending agent which can be cured to form a catheter or which can be formed to provide a coating on a previously formed catheter. The suspending agent is coated to either form the catheter or to form a coating on a catheter. Upon curing of the suspending agent, an outer surface is formed on the catheter, which outer surface includes the antimicrobial metal compound, thereby imparting antimicrobial activity to the catheter.
Inventors
- 👤 Robert L. Murtfeldt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:53
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
110 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: selecting a catheter from the group consisting of silicone catheters and latex catheters to be coated with an antimicrobial coating; comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; suspending the comminuted antimicrobial metal compound in a curable suspending agent capable of bonding to the surface of the catheter; coating the catheter with the suspending agent containing suspended antimicrobial metal compound; and curing the suspending agent to bond the suspending agent containing antimicrobial metal compound to the surface of the catheter and to form an antimicrobial catheter.
Claim 2
Independent Claim
110 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: selecting a catheter from the group consisting of silicone catheters and latex catheters to be coated with an antimicrobial coating; comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; suspending the comminuted antimicrobial metal compound in a curable suspending agent capable of bonding to the surface of the catheter; coating the catheter with the suspending agent containing suspended antimicrobial metal compound; and curing the suspending agent to bond the suspending agent containing antimicrobial metal compound to the surface of the catheter and to form an antimicrobial catheter.
Claim 3
Dependent Claim
32 words
A method as recited in claim 1 wherein the suspending step comprises suspending the antimicrobial metal compound in a curable suspending agent selected from the group consisting of silicone, polyurethane and tetrafluoroethylene.
Claim 4
Dependent Claim
21 words
A method as recited in claim 1 wherein the antimicrobial metal compound is selected from compounds of silver, gold and copper.
Claim 5
Dependent Claim
15 words
A method as recited in claim 3 wherein the antimicrobial metal compound comprises silver oxide.
Claim 6
Dependent Claim
15 words
A method as recited in claim 3 wherein the antimicrobial metal compound comprises gold thioglycolate.
Claim 7
Dependent Claim
16 words
A method as recited in claim 1 wherein the catheter comprises a latex natural rubber catheter.
Claim 8
Dependent Claim
22 words
A method as recited in claim 6 wherein the suspending agent is selected from the group consisting of silicone, polyurethane and tetrafluoroethylene.
Claim 9
Dependent Claim
13 words
A method as recited in claim 7 wherein the suspending agent comprises silicone.
Claim 10
Dependent Claim
15 words
A method as recited in claim 8 wherein the antimicrobial metal compound comprises silver oxide.
Claim 11
Dependent Claim
14 words
A method as recited in claim 1 wherein the catheter comprises a silicone catheter.
Claim 12
Dependent Claim
22 words
A method as recited in claim 10 wherein the suspending agent is selected from the group consisting of silicone, polyurethane and tetrafluoroethylene.
Claim 13
Dependent Claim
13 words
A method as recited in claim 11 wherein the suspending agent comprises silicone.
Claim 14
Dependent Claim
15 words
A method as recited in claim 12 wherein the antimicrobial metal compound comprises silver oxide.
Claim 15
Independent Claim
107 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: (a) comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; (b) suspending the comminuted antimicrobial metal compound in a curable suspending agent selected from the group consisting of silicone, polyurethane and tetrafluoroethylene; (c) selecting a catheter from the group consisting of latex and silicone catheters; (d) coating the selected catheter with the suspending agent; and (e) curing the coating of suspending agent to form a layer of the cured suspending agent containing the comminuted antimicrobial metal compound bonded to the surface of the catheter.
Claim 16
Independent Claim
107 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: (a) comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; (b) suspending the comminuted antimicrobial metal compound in a curable suspending agent selected from the group consisting of silicone, polyurethane and tetrafluoroethylene; (c) selecting a catheter from the group consisting of latex and silicone catheters; (d) coating the selected catheter with the suspending agent; and (e) curing the coating of suspending agent to form a layer of the cured suspending agent containing the comminuted antimicrobial metal compound bonded to the surface of the catheter.
Claim 17
Dependent Claim
25 words
A method as recited in claim 14 wherein the antimicrobial metal compound is selected from the group consisting of compounds of silver, gold and copper.
Claim 18
Dependent Claim
15 words
A method as recited in claim 15 wherein the antimicrobial metal compound comprises silver oxide.
Claim 19
Dependent Claim
20 words
A method as recited in claim 14 wherein the suspending agent comprises silicone and the catheter comprises a latex catheter.
Claim 20
Dependent Claim
15 words
A method as recited in claim 17 wherein the antimicrobial metal compound comprises silver oxide.
Claim 21
Dependent Claim
36 words
A method as recited in claim 14 further comprising the step of leaching the selected catheter with a leaching agent for removing undesirable compounds from the catheter prior to coating the catheter with the suspending agent.
Claim 22
Dependent Claim
47 words
A method as recited in claim 14 further comprising the step of preparing the surface of the catheter by contacting the surface with a bridging compound which is compatible with the material of the catheter and the suspending agent for bonding the suspending agent to the catheter.
Claim 23
Dependent Claim
26 words
A method as recited in claim 20 wherein the catheter comprises a latex catheter, the suspending agent comprises silicone and the bridging compound comprises mercaptopropyl trimethoxysilane.
Claim 24
Dependent Claim
28 words
A method as recited in claim 20 further comprising coating the catheter with an intermediate coating of the suspending agent after preparing the surface with the bridging compound.
Claim 25
Dependent Claim
25 words
A method as recited in claim 14 wherein the coating comprises a coating having a thickness of about 1 to about 15 microns in thickness.
Claim 26
Dependent Claim
19 words
A method as recited in claim 14 wherein the coating comprises about 0.2 milligrams to about 50 milligrams silver.
Claim 27
Independent Claim
151 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: (a) selecting a catheter from the group consisting of latex and silicone catheters; (b) comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; (c) suspending the comminuted antimicrobial metal compound in a curable suspending agent; (d) leaching the selected catheter for removing any antioxidants, catalysts and other undesirable compounds which can be present in the catheter as a result of the process for forming the catheter; (e) preparing the surface of the selected catheter with a bridging compound by reacting the bridging compound with the catheter; (f) coating the catheter with the suspending agent containing the comminuted antimicrobial metal compound; and (g) curing the suspending agent to form a layer of the cured suspending agent containing the comminuted antimicrobial metal compound bonded to the surface of the catheter.
Claim 28
Independent Claim
151 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: (a) selecting a catheter from the group consisting of latex and silicone catheters; (b) comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; (c) suspending the comminuted antimicrobial metal compound in a curable suspending agent; (d) leaching the selected catheter for removing any antioxidants, catalysts and other undesirable compounds which can be present in the catheter as a result of the process for forming the catheter; (e) preparing the surface of the selected catheter with a bridging compound by reacting the bridging compound with the catheter; (f) coating the catheter with the suspending agent containing the comminuted antimicrobial metal compound; and (g) curing the suspending agent to form a layer of the cured suspending agent containing the comminuted antimicrobial metal compound bonded to the surface of the catheter.
Claim 29
Dependent Claim
15 words
A method as recited in claim 25 wherein the antimicrobial metal compound comprises silver oxide.
Claim 30
Dependent Claim
22 words
A method as recited in claim 25 wherein the suspending agent is selected from the group consisting of silicone, polyurethane and tetrafluoroethylene.
Claim 31
Dependent Claim
13 words
A method as recited in claim 27 wherein the suspending agent comprises silicone.
Claim 32
Dependent Claim
32 words
A method as recited in claim 25 wherein the catheter comprises a latex catheter, the suspending agent comprises silicone and the surface of the catheter is prepared by reacting with mercaptopropyl trimethoxysilane.
Claim 33
Dependent Claim
25 words
A method as recited in claim 25 wherein the selected catheter is solvent leached with a ternary azeotropic mixture comprising toluene, isopropyl alcohol and water.
Claim 34
Dependent Claim
28 words
A method as recited in claim 25 further comprising coating the catheter with an intermediate coating of the suspending agent after preparing the surface with the bridging compound.
Claim 35
Independent Claim
170 words
A method for forming a urological catheter having antimicrobial activity for inhibiting microbial migration along the catheter, the method comprising the steps of: (a) forming a latex urological catheter; (b) leaching the latex catheter with a leaching solution comprising a ternary azeotropic mixture of toluene, isopropyl alcohol and water for removing antioxidants and catalysts which can be present in the latex catheter as a result of the forming of the latex catheter; (c) preparing the surface of the latex catheter by coating the surface with mercaptopropyl trimethoxsilane; (d) comminuting silver oxide to a particle size of up to about 30 microns in diameter; (e) suspending the comminuted silver oxide in a room temperature vulcanizable silicone; (f) coating the surface of the latex catheter with the suspension containing the comminuted silver oxide; and (g) curing the coating of suspending agent to form a layer of the cured suspending agent containing the comminuted silver oxide bonded to the surface of the latex catheter for forming a latex catheter having an antimicrobial surface.
Claim 36
Independent Claim
170 words
A method for forming a urological catheter having antimicrobial activity for inhibiting microbial migration along the catheter, the method comprising the steps of: (a) forming a latex urological catheter; (b) leaching the latex catheter with a leaching solution comprising a ternary azeotropic mixture of toluene, isopropyl alcohol and water for removing antioxidants and catalysts which can be present in the latex catheter as a result of the forming of the latex catheter; (c) preparing the surface of the latex catheter by coating the surface with mercaptopropyl trimethoxsilane; (d) comminuting silver oxide to a particle size of up to about 30 microns in diameter; (e) suspending the comminuted silver oxide in a room temperature vulcanizable silicone; (f) coating the surface of the latex catheter with the suspension containing the comminuted silver oxide; and (g) curing the coating of suspending agent to form a layer of the cured suspending agent containing the comminuted silver oxide bonded to the surface of the latex catheter for forming a latex catheter having an antimicrobial surface.
Claim 37
Dependent Claim
30 words
A method as recited in claim 32 wherein the coating of cured suspending agent on the surface of the catheter comprises about 0.2 milligrams to about 50 milligrams silver oxide.
Claim 38
Dependent Claim
28 words
A method as recited in claim 32 further comprising coating the catheter with an intermediate coating of the suspending agent after preparing the surface with the bridging compound.
Claim 39
Dependent Claim
38 words
A method as recited in claim 32 further comprising the step of treating the coated catheter with a solvent for the cured suspending agent for exposing at least a portion of the antimicrobial metal compound in the coating.
Claim 40
Dependent Claim
28 words
A method as recited in claim 32 wherein the suspending agent and the solvent is selected the group consisting of potassium hydroxide, hydrogen peroxide and methyl ethyl ketone.
Claim 41
Independent Claim
116 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: selecting a catheter from the group consisting of silicone catheters and latex catheters to be coated with an antimicrobial coating; comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; suspending the comminuted antimicrobial metal compound in a curable suspending agent capable of bonding to the surface of the catheter; coating the catheter with the suspending agent containing suspended antimicrobial metal compound; and curing the suspending agent to bond the suspending agent containng antimicrobial metal compound to the surface of the catheter and to form an antimicrobial catheter having a fixed antimicrobial metal compound.
Claim 42
Independent Claim
116 words
A method for the production of an antimicrobial catheter, the method comprising the steps of: selecting a catheter from the group consisting of silicone catheters and latex catheters to be coated with an antimicrobial coating; comminuting an antimicrobial metal compound to a particle size of up to about 30 microns in diameter; suspending the comminuted antimicrobial metal compound in a curable suspending agent capable of bonding to the surface of the catheter; coating the catheter with the suspending agent containing suspended antimicrobial metal compound; and curing the suspending agent to bond the suspending agent containng antimicrobial metal compound to the surface of the catheter and to form an antimicrobial catheter having a fixed antimicrobial metal compound.
Claim 43
Dependent Claim
47 words
A method as recited in claim 25 further comprising the step of coating the prepared surface of the catheter on which the bridging agent is coated with a layer of suspending agent prior to coating the catheter with the suspending agent containing the comminuted antimicrobial metal compound.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-02 | 1989-12-02 | 1990-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-02 | 1993-12-02 | 1994-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-02 | 1997-12-02 | 1998-06-03 | $7700.00 | Window Closed / Lapsed |