US4590068A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inert cross-linked copolymer support, its preparation process and its use for producing delayed action medicaments
Assignee: Oris Industrie SA
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Filing: 1983-08-22
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Granted: 1986-05-20
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Expires: 2003-08-22
Abstract
Abstract Inert cross-linked copolymer able to absorb and then progressively release a pharmaceutically active substance, wherein it is constituted by a powder of a cross-linked copolymer comprising 30 to 80% by weight of monounsaturated alkyl acrylate and/or methacrylate; 5 to 68% by weight of acrylic and/or methacrylic acid; and 2 to 15% by weight of bifunctional or trifunctional acrylate and/or methacrylate polymerized in accordance with free radical polymerization mechanisms.
Inventors
- 👤 Jeanne Berthet
- 👤 Marie-Francoise Blin
- 👤 Gilbert Gaussens
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
114 words
A pharmaceutical composition comprising an inert support and codeine and/or 2-(3-benzoyphenyl)-propionic acid absorbed thereinto, wherein the inert support is constituted by a powder of a cross-linked copolymer of: 30-80% by weight of a mono-unsaturated alkyl acrylate and/or alkyl methacrylate wherein the alkyl acrylate is selected from the group consisting of butyl, hexyl and heptylacrylates and the methacrylate is selected from the group consisting of methyl, ethyl, butyl, hexyl and heptylmethacrylates; 5-68% by weight of acrylic and/or methacrylic acid; and 2-15% by weight of bifunctional or trifunctional acrylate and/or methacrylate selected from the group consisting of polyethylene glycol diacrylate, trimethylol propane triacrylate and trimethylol propane trimethacrylate, said powder having a grain size of 20-700 microns.
Claim 2
Dependent Claim
114 words
A pharmaceutical composition comprising an inert support and codeine and/or 2-(3-benzoyphenyl)-propionic acid absorbed thereinto, wherein the inert support is constituted by a powder of a cross-linked copolymer of: 30-80% by weight of a mono-unsaturated alkyl acrylate and/or alkyl methacrylate wherein the alkyl acrylate is selected from the group consisting of butyl, hexyl and heptylacrylates and the methacrylate is selected from the group consisting of methyl, ethyl, butyl, hexyl and heptylmethacrylates; 5-68% by weight of acrylic and/or methacrylic acid; and 2-15% by weight of bifunctional or trifunctional acrylate and/or methacrylate selected from the group consisting of polyethylene glycol diacrylate, trimethylol propane triacrylate and trimethylol propane trimethacrylate, said powder having a grain size of 20-700 microns.
Claim 3
Dependent Claim
20 words
A pharmaceutical composition according to claim 1, wherein said polyethylene glycol diacrylate is diethylene glycol diacrylate or tetraethylene glycol diacrylate.
Claim 4
Dependent Claim
19 words
A pharmaceutical composition according to claim 1, wherein the powder has a grain size of 100 to 400 micron.
Claim 5
Dependent Claim
19 words
A pharmaceutical composition according to claim 1, wherein the powder has a grain size of 20 to 50 micron.
Claim 6
Dependent Claim
22 words
A pharmaceutical composition according to claim 1, wherein the copolymer is a copolymer of butyl methacrylate, acrylic acid and trimethylol propane triacrylate.
Claim 7
Dependent Claim
22 words
A pharmaceutical composition according to claim 1, wherein the copolymer is a copolymer of butyl methacrylate, acrylic acid and tetraethylene glycol diacrylate.
Claim 8
Dependent Claim
22 words
A pharmaceutical composition according to claim 1, wherein the copolymer is a copolymer of heptyl methacrylate, acrylic acid and trimethylol propane trimethacrylate.
Claim 9
Dependent Claim
22 words
A pharmaceutical composition according to claim 1, wherein the copolymer is a copolymer of butyl methacrylate, acrylic acid and trimethylol propane trimethacrylate.
References Cited (Backward Citations)
US3080346A
Cited
US3881026A
Cited
US3608063A
Cited
US3959237A
Cited
US3966902A
Cited
US4234467A
Cited
US4411754A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-19 | 1989-11-18 | 1990-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-19 | 1993-11-18 | 1994-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-19 | 1997-11-18 | 1998-05-20 | $7700.00 | Window Closed / Lapsed |