US4411754A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing a polymer composition
Assignee: Japan Atomic Energy Agency
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Filing: 1981-02-13
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Granted: 1983-10-25
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Expires: 2001-02-13
Abstract
Abstract A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, making the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.
Inventors
- 👤 Isao Kaetsu
- 👤 Masaru Yoshida
- 👤 Minoru Kumakura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:09
CPC Classifications
C; C08; C08F; C08F2/00; C08F2/44; A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/70; A61K9/7007
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
120 words
A process for preparing a polymer composition containing a physiologically active substance, said composition capable of releasing said physiologically active substance at a controlled rate, characterized by mixing one or more polymerizable monomers and said physiologically active substance in the absence or presence of a crystallizable substance, intended to increase the surface area for elution of said substance, and wherein an adsorbent is added from the group consisting of active carbon, silica-gel, kaolin and ion exchange resins, to adsorb a solution of physiologically active substance when an elution medium permeates into the composition, and irradiating the resulting mixture with light or an ionizing radiation at a temperature below 0° C. to polymerize said polymerizable monomers, to yield said polymer composition.
Claim 2
Dependent Claim
120 words
A process for preparing a polymer composition containing a physiologically active substance, said composition capable of releasing said physiologically active substance at a controlled rate, characterized by mixing one or more polymerizable monomers and said physiologically active substance in the absence or presence of a crystallizable substance, intended to increase the surface area for elution of said substance, and wherein an adsorbent is added from the group consisting of active carbon, silica-gel, kaolin and ion exchange resins, to adsorb a solution of physiologically active substance when an elution medium permeates into the composition, and irradiating the resulting mixture with light or an ionizing radiation at a temperature below 0° C. to polymerize said polymerizable monomers, to yield said polymer composition.
Claim 3
Dependent Claim
114 words
A process for preparing a polymer composition having a function of releasing a physiologically active substance at a controlled rate which comprises dropping or injecting a mixture of one or more monomers vitrifiable at low temperatures containing 5 to 50%, by weight, of synthetic high molecular weight substance and said physiologically active substance into a medium at low temperatures to make it into a shape of spherical structure, and thereafter irradiating it with light or an ionizing radiation at a low temperature below room temperature to polymerize said monomers, to yield a composition capable of releasing said physiologically active substance at a controlled rate, and releasing said physiologically active substance at said controlled rate.
Claim 4
Dependent Claim
114 words
A process for preparing a polymer composition having a function of releasing a physiologically active substance at a controlled rate which comprises dropping or injecting a mixture of one or more monomers vitrifiable at low temperatures containing 5 to 50%, by weight, of synthetic high molecular weight substance and said physiologically active substance into a medium at low temperatures to make it into a shape of spherical structure, and thereafter irradiating it with light or an ionizing radiation at a low temperature below room temperature to polymerize said monomers, to yield a composition capable of releasing said physiologically active substance at a controlled rate, and releasing said physiologically active substance at said controlled rate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-24 | 1987-04-25 | 1987-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-24 | 1991-04-25 | 1991-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-24 | 1995-04-25 | 1995-10-25 | $7700.00 | Window Closed / Lapsed |