Bio Compatible and Blood Compatible Materials and Methods

Claim 2

A bio- and blood compatible material for human and animal use comprising: a substrate having functional groups extending from at least a portion of the surface thereof, said functional groups being selected from the group consisting of primary and secondary amino groups, said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and arylhalide groups, a biological coupled to said substrate by reaction between the primary or secondary amine or hydroxyl of said biological and the aldehyde and arylhalide groups attached to said primary and secondary amines which extend from said surface, and said biological operating to provide bio- and blood compatible qualities to said surface portion.

Claim 3

A material as set forth in Claim 1 wherein said substrate is rigid.

Claim 4

A material as set forth in Claim 1 wherein said substrate is flexible.

Claim 5

A material as set forth in Claim 1 wherein said biological is a material selected from the group consisting of proteins, carbohydrates, lipids, amino acids, and peptides.

Claim 6

A material as set forth in Claim 3 wherein the biological is a material selected from the group consisting of heparin, chrondroitin sulfate C, egg albumin, collagen, lysine, fibrinogen, hemiglobin, aspartic acid, alanine, glutamic acid, glycine, glyclglycine, human albumin, gelatin, and lecithin.

Claim 7

A material as set forth in Claim 1 wherein said amino group has an arylhalide group attached thereto.

Claim 8

A material as set forth in Claim 1 wherein said biological is gelatin.

Claim 9

A material as set forth in Claim 1 wherein said substrate is a tubular member.

Claim 10

A material as set forth in Claim 1 wherein said substrate is a composite of a nylon mesh stretchable in all directions and compliant and includes a silicone rubber facing, said biological being coupled to the surface of the silicone rubber facing which is in contact with said mesh.

Claim 11

A material for use as a dressing for thermal burns comprising: a composite elastomeric substrate which includes a fabric backing and a facing of a thin thermoplastic material, said composite elastomeric substrate being stretchable in all directions and compliant, said thermoplastic having functional groups selected from the group consisting of primary and secondary amino groups extending from at least a portion of the surface thereof, said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and arylchloride groups, a biological coupled to said thermoplastic by reaction between the primary or secondary amine, or hydroxyl group of said biological and the aldehyde and aryichloride groups attached to said primary and secondary amino groups extending from at least a portion of said surface, and said biological imparting bio- and blood compatible characteristics to said portion of said surface.

Claim 12

A material for use as a dressing for thermal burns comprising: a composite elastomeric substrate which includes a fabric backing and a facing of a thin thermoplastic material, said composite elastomeric substrate being stretchable in all directions and compliant, said thermoplastic having functional groups selected from the group consisting of primary and secondary amino groups extending from at least a portion of the surface thereof, said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and arylchloride groups, a biological coupled to said thermoplastic by reaction between the primary or secondary amine, or hydroxyl group of said biological and the aldehyde and aryichloride groups attached to said primary and secondary amino groups extending from at least a portion of said surface, and said biological imparting bio- and blood compatible characteristics to said portion of said surface.

Claim 13

A material as set forth in Claim 10 wherein said composite elastomeric substrate has a water vapor transmission rate, as measured at 370C for 24 hours, in the range of 10 to 15 grams per hour per meter squared.

Claim 14

A material as set forth in Claim 10 wherein the thermoplastic material has a thickness in the range of .0006 to 0.020 inches.

Claim 15

A material as set forth in Claim 10 wherein said thermoplastic has a thickness in the range of 0.0008 and 0.0012 inches.

Claim 16

A material as set forth in Claim 10 wherein said thermoplastic is selected from the group consisting of silicone rubber, elastomer polysiloxanes, natural rubber, polybutadiene, styrenebutadiene, butyl rubber, polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyvinyl acetate, and ethacrylate and methacrylate polymers and copolymers.

Claim 17

1 5. A material as set forth in Claim 10 wherein said biological is selected from the group consisting of heparin, chrondroitin sulfate C, egg albumin, collagen, lysine, alanine, glutamic acid, glycine, glyclglycine, human albumin, gelatin and lecithin.

Claim 18

A material as set forth in Claim 10 wherein said composite elastomericsubstrate has an elongation in each direction of at least 50%.

Claim 19

A material as set forth in Claim 1 6 wherein said fabric is an 18/3 nylon mesh.

Claim 20

A material as set forth in Claim 10 wherein said material is sterile.

Claim 21

A material as set forth in Claim 10 wherein said biological is gelatin.

Claim 22

A material as set forth in Claim 10 wherein said biological is human albumin.

Claim 23

A material for use as a dressing for thermal burns comprising: a sterilized composite matrix substrate, said substrate including a mesh fabric backing which has an elongation in each direction of at least 50%, a silicone rubber membrane member attached to said fabric, said silicone rubber membrane having a thickness in the range of between 0.008 and 0.0012 inches, and a biological chemically coupled to at least a portion of the surface of said substrate in an amount sufficient to provide bio- and blood compatible characteristics thereto.

Claim 24

A material for use as a dressing for thermal burns comprising: a sterilized composite matrix substrate, said substrate including a mesh fabric backing which has an elongation in each direction of at least 50%, a silicone rubber membrane member attached to said fabric, said silicone rubber membrane having a thickness in the range of between 0.008 and 0.0012 inches, and a biological chemically coupled to at least a portion of the surface of said substrate in an amount sufficient to provide bio- and blood compatible characteristics thereto.

Claim 25

A material as set forth in Claim 21 wherein said biological is human albumin.

Claim 26

A material as set forth in Claim 21 wherein said biological is gelatin.

Claim 27

A material as set forth in Claim 21 wherein said matrix substrate has a water vapor transmission rate, as measured at 370C for 24 hours, in the range of between 10 and 15 grams per meter squared.

Claim 30

A method as set forth in Claim 25 wherein said substrate is a fabric elastomer matrix and wherein said biological is coupled to the surface of said elastomer contacted by said fabric.

Claim 31

A method as set forth in Claim 26 wherein said biological is gelatin.

Claim 32

A method as set forth in Claim 26 wherein said biological is human albumin.

Claim 33

A method as set forth in Claim 26 wherein said substrate is a nylon mesh fabric having an elongation of at least 50% in each direction and said elastomer being a silicone rubber membrane of a thickness between .0006 and .020 inches.

Claim 34

A method as set forth in Claim 29 further including the step of sterilizing the resultant product.