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US4535485A Expired / Lapsed US ⏱️ 0.0 years remaining

Polymeric acrylic prothesis

Assignee: United States Surgical Corp
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Filing: 1982-03-12
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Granted: 1985-08-20
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Expires: 2002-03-12
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Abstract

Abstract This invention relates to implantable porous prostheses for use as bone or hard tissue replacements anywhere in the body. The porous implants comprise loose, individual polymeric particles of a specified size, coated with a hydrophilic material and barium sulfate particles. The prostheses are biologically compatible in the body and promote bone and tissue ingrowth and attachment. This invention also relates to a method for producing the novel prosthetic devices disclosed herein.

Inventors

  • 👤 Arthur Ashman
  • 👤 Paul F. Bruins

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 16:34
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61B; A61B90/00; A61B90/39

Claims Analysis

Total Claims: 34
Claim 1
Independent Claim 156 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 2
Dependent Claim 156 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 3
Dependent Claim 26 words
The packing material of claim 1 in which the diameter of the particles is in the range of from about 590 microns to about 840 microns.
Claim 4
Dependent Claim 20 words
The packing material of claim 2 in which the cores of the particles are composed of an acrylic polymeric material.
Claim 5
Dependent Claim 16 words
The packing material of claim 3 in which the cores of the particles are polymethylmethacrylate beads.
Claim 6
Dependent Claim 14 words
The packing material of claim 4 in which the polymethylmethacrylate beads include a plasticizer.
Claim 7
Dependent Claim 23 words
The packing material of claim 3 in which the cores of the particles are composed of a copolymer of methylmethacrylate and a comonomer.
Claim 8
Dependent Claim 16 words
The packing material of claim 3 in which the hydrophilic polymeric material is a polymeric hydroxyethylmethacrylate.
Claim 9
Dependent Claim 180 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packaging material comprising disjoint particles, having a diameter in the range of from about 590 microns to about 840 microns, each particle having an inner core comprised of a biologically-compatible acrylic polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a biologically-compatible hydrophilic polymeric hydroxyethylmethacrylate material, the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having a least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 10
Dependent Claim 180 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packaging material comprising disjoint particles, having a diameter in the range of from about 590 microns to about 840 microns, each particle having an inner core comprised of a biologically-compatible acrylic polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a biologically-compatible hydrophilic polymeric hydroxyethylmethacrylate material, the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having a least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 11
Dependent Claim 21 words
The packing material of claim 8 in which the polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.
Claim 12
Dependent Claim 14 words
The packing material of claim 9 in which the cross-linking agent is triethyleneglycol dimethacrylate.
Claim 13
Dependent Claim 35 words
The packing material of claim 10 in which the ratio of the weight of the triethyleneglycol dimethacrylate to the weight of the monomeric hydroxyethylmethacrylate is in the range of from about 0.01 to about 0.05.
Claim 14
Dependent Claim 20 words
The packing material of claim 8 in which the barium sulfate is located in the coating of hydrophilic polymeric material.
Claim 15
Dependent Claim 37 words
The packing material of claim 12 in which the ratio of the weight of the barium sulfate to the weight of the cores of the particles is in the range of from about 0.25 to about 0.43.
Claim 16
Dependent Claim 26 words
The packing material of claim 13 in which the barium sulfate is in the form of particles having a diameter of less than about one micron.
Claim 17
Dependent Claim 135 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a radio-opaque material, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 18
Dependent Claim 135 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a radio-opaque material, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 19
Dependent Claim 26 words
The packing material of claim 15 in which the diameter of the particles is in the range of from about 590 microns to about 840 microns.
Claim 20
Dependent Claim 20 words
The packing material of claim 16 in which the cores of the particles are composed of an acrylic polymeric material.
Claim 21
Dependent Claim 16 words
The packing material of claim 17 in which the cores of the particles are polymethylmethacrylate beads.
Claim 22
Dependent Claim 14 words
The packing material of claim 18 in which the polymethylmethacrylate beads include a plasticizer.
Claim 23
Dependent Claim 23 words
The packing material of claim 17 in which the cores of the particles are composed of a copolymer of methylmethacrylate and a comonomer.
Claim 24
Dependent Claim 16 words
The packing material of claim 17 in which the hydrophilic polymeric material is a polymeric hydroxyethylmethacrylate.
Claim 25
Dependent Claim 37 words
The packing material of claim 21 in which the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07.
Claim 26
Dependent Claim 21 words
The packing material of claim 22 in which the polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.
Claim 27
Dependent Claim 14 words
The packing material of claim 23 in which the cross-linking agent is triethyleneglycol dimethacrylate.
Claim 28
Dependent Claim 35 words
The packing material of claim 24 in which the ratio of the weight of the triethyleneglycol dimethacrylate to the weight of the monomeric hydroxyethylmethacrylate is in the range of from about 0.01 to about 0.05.
Claim 29
Dependent Claim 14 words
The packing material of claim 21 in which the radio-opaque material is barium sulfate.
Claim 30
Dependent Claim 20 words
The packing material of claim 26 in which the barium sulfate is located in the coating of hydrophilic polymeric material.
Claim 31
Dependent Claim 37 words
The packing material of claim 27 in which the ratio of the weight of the barium sulfate to the weight of the cores of the particles is in the range of from about 0.25 to about 0.43.
Claim 32
Dependent Claim 26 words
The packing material of claim 28 in which the barium sulfate is in the form of particles having a diameter of less than about one micron.
Claim 33
Dependent Claim 144 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to prevent bonding between the particles, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 34
Dependent Claim 144 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to prevent bonding between the particles, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-08-19 1989-02-18 1989-08-20 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-08-19 1993-02-18 1993-08-20 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-08-19 1997-02-18 1997-08-20 $7700.00 Window Closed / Lapsed

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